milciclib
Small moleculeexperimental
Clinical trial activity
5 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2006 (NCT01300468)
Timeline
Indications
Mechanism of action
- Nerve growth factor receptor Trk-AINHIBITOR
NTRK1 inhibitor
- Cyclin-dependent kinase 2INHIBITOR
CDK2 inhibitor
- Cyclin-dependent kinase 4INHIBITOR
CDK4 inhibitor
- Cyclin-dependent kinase 1INHIBITOR
CDK1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2- Mol. weight
- 460.59 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL564829 ↗
Also known as
- milciclib
- milciclib
- milciclib maleate
- milciclib maleate
- n,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1h-pyrazolo(4,3-h)quinazoline-3-carboxamide
- pha848125
- pha 848125
- pha-848125
- pha-848125
- pha-848125
- pha-848125
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05651269 | Phase 2 | Mar 15, 2023 | Tiziana Life Sciences, PLC |
| NCT03109886 | Phase 2 | Jun 1, 2017 | Istituto Clinico Humanitas - Rozzano (MI), Italy, Tiziana Life Sciences, PLC |
| NCT01301391 | Phase 2 | Jan 1, 2011 | Georgetown University, National Cancer Institute (NCI), Nerviano Medical Sciences, Tiziana Life Sciences, PLC, University of Milan |
| NCT01011439 | Phase 2 | Mar 1, 2009 | HOPITAL LARREY - TOULOUSE, Institut Gustave Roussy, National Cancer Institute (NCI), Nerviano Medical Sciences, Scottsdale Healthcare, Tiziana Life Sciences, PLC, University of Milan, University of Turin |
| NCT01300468 | Phase 1 | Apr 1, 2006 | Johns Hopkins University, Nerviano Medical Sciences, Scottsdale Healthcare |
Showing 5 of 5 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Tiziana Life Sciences, PLC | For profit | 4 | 4 | 1 | 2009 |
| Nerviano Medical Sciences | For profit | 3 | 1 | 2 | 2006 |
| National Cancer Institute (NCI) | Government | 2 | 0 | 1 | 2009 |
| Scottsdale Healthcare | Academic/Hospital | 2 | 0 | 2 | 2006 |
| University of Milan | Academic/Hospital | 2 | 0 | 1 | 2009 |
| Georgetown University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| HOPITAL LARREY - TOULOUSE | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Institut Gustave Roussy | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Istituto Clinico Humanitas - Rozzano (MI), Italy | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Johns Hopkins University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| University of Turin | Academic/Hospital | 1 | 0 | 1 | 2009 |
11 organizations
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