pardoprunox

Small moleculeexperimental

Pardoprunox is an antiparkinsonian drug developed by Solvay for the treatment of Parkinson's disease that reached phase III clinical trials before being discontinued. It was also being investigated for the treatment of depression and anxiety but these indications appear to have been abandoned as well. — Wikipedia

Clinical trial activity

7 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
7
Phase 3
6
Phase 4
0

Earliest trial started Oct 1, 2005 (NCT00134251)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CN1CCN(c2cccc3[nH]c(=O)oc23)CC1
Mol. weight
233.27 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 2(3h)-benzoxazolone, 7-(4-methyl-1-piperazinyl)-monohydrochloride
  • du-126891
  • du-126891
  • pardoprunox
  • pardoprunox
  • pardoprunox
  • pardoprunox
  • pardoprunox
  • slv308
  • slv308
  • slv-308
  • slv-308
  • slv-308
  • sme-308

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT00903838Phase 2Sep 1, 2009Abbott
NCT00335374Phase 3Aug 1, 2007Solvay
NCT00407095Phase 3Aug 1, 2007Abbott, Solvay
NCT00332917Phase 3Feb 1, 2007Solvay
NCT00335166Phase 3Nov 1, 2006Solvay
NCT00269516Phase 3Jun 1, 2006Solvay
NCT00134251Phase 3Oct 1, 2005Solvay
Showing 7 of 7 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
SolvayFor profit6612005
AbbottFor profit2122007
2 organizations
Page 1 / 1