monophosphoryl lipid a
Small moleculeexperimental
Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. While its toxic effects can be damaging, the sensing of lipid A by the immune system may also be critical for the onset of immune responses to gram-negative infection, and for the subsequent successful fight against the infection. — Wikipedia
Clinical trial activity
22 trials · 14 clinical orgs · 0 marketing orgs
Phase 1
10
Phase 2
13
Phase 3
9
Phase 4
0
Earliest trial started May 1, 1992 (NCT00698893)
Timeline
Indications
Studied for
- Hepatitis B · Phase 3
- Herpes Labialis · Phase 3
- Herpes Simplex · Phase 3
- HIV · Phase 1
- HIV Infections · Phase 1
- Hypersensitivity, Immediate · Phase 1
- Leishmaniasis · Phase 1
- Leishmaniasis, Cutaneous · Phase 2
- Lung Neoplasms · Phase 1/Phase 2
- Melanoma · Phase 1/Phase 2
- Neoplasms · Phase 1/Phase 2
- Norovirus · Phase 1
- Ovarian Neoplasms · Phase 1/Phase 2
Mechanism of action
- Toll-like receptor 4ACTIVATOR
TLR4 activator
- TLR4-MD2ACTIVATOR
TLR4-MD2 activator
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLipid A ↗
Also known as
- gsk208141
- lipid a
- lipid a
- monophosphoryl lipid a
- mpl
- mpl
- mpla
- mpla
- mpl-se
- sb208141
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06449196 | Early Phase 1 (Phase 1) | Aug 1, 2024 | International AIDS Vaccine Initiative, Polymun Scientific GmbH |
| NCT05290727 | N/A | Mar 1, 2022 | Instituto Universitario de Oftalmobiología Aplicada |
| NCT03961438 | Phase 1 | Jul 31, 2019 | University of Amsterdam |
| NCT03408262 | Phase 1 | Oct 6, 2017 | Imperial College London |
| NCT01751048 | Phase 1 | Mar 1, 2013 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT01584115 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2012 | Butantan Institute, Instituto de Investigação em Imunologia |
| NCT01011309 | Phase 2 | Oct 1, 2009 | Immune Design, Infectious Disease Research Institute |
| NCT00806962 | Phase 1 | Nov 1, 2008 | LigoCyte, University of Rochester |
| NCT00241410 | Phase 1 | Dec 1, 2005 | Allergy Therapeutics |
| NCT00224484 | Phase 3 | Apr 1, 2004 | GlaxoSmithKline |
| NCT00224471 | Phase 3 | Dec 1, 2003 | GlaxoSmithKline |
| NCT00057330 | Phase 3 | Jan 1, 2003 | GlaxoSmithKline |
| NCT00001042 | Phase 1 | Nov 2, 1999 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT00697931 | Phase 3 | May 1, 1997 | GlaxoSmithKline |
| NCT00698568 | Phase 3 | Oct 1, 1996 | GlaxoSmithKline |
| NCT00699764 | Phase 3 | Mar 1, 1996 | GlaxoSmithKline |
| NCT00698490 | Phase 1/Phase 2 (Phase 2) | Aug 1, 1995 | GlaxoSmithKline |
| NCT00698087 | Phase 3 | Jan 1, 1995 | GlaxoSmithKline |
| NCT00697242 | Phase 3 | Jan 1, 1994 | GlaxoSmithKline |
| NCT00697970 | Phase 3 | Nov 1, 1993 | GlaxoSmithKline |
Showing 20 of 22 trials
Page 1 / 2
Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 12 | 12 | 3 | 1992 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 2 | 2 | 1 | 1999 |
| Allergy Therapeutics | For profit | 1 | 1 | 1 | 2005 |
| Butantan Institute | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Immune Design | For profit | 1 | 0 | 1 | 2009 |
| Imperial College London | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Infectious Disease Research Institute | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Instituto de Investigação em Imunologia | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Instituto Universitario de Oftalmobiología Aplicada | Academic/Hospital | 1 | 1 | 1 | 2022 |
| International AIDS Vaccine Initiative | Academic/Hospital | 1 | 1 | 1 | 2024 |
| LigoCyte | For profit | 1 | 1 | 1 | 2008 |
| Polymun Scientific GmbH | For profit | 1 | 0 | 1 | 2024 |
| University of Amsterdam | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Rochester | Academic/Hospital | 1 | 0 | 1 | 2008 |
14 organizations
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