loxoprofen
Small moleculeexperimental
Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in some countries for oral administration. A transdermal preparation was approved for sale in Japan in January 2006; medicated tape and gel formulations followed in 2008 and 2010. — Wikipedia
Clinical trial activity
16 trials · 22 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
10
Phase 3
5
Phase 4
2
Earliest trial started Oct 1, 2004 (NCT00141154)
Timeline
Indications
Approved for
Studied for
- Ankle Joint · Phase 2
- Arthritis, Rheumatoid · Phase 2
- Back Pain · Phase 2
- Chronic Pain · Phase 2
- Fever · Phase 3
- Healthy Volunteers · Phase 4
- Low Back Pain · Phase 3
- Lumbar Vertebrae · Phase 3
- Pain · Phase 3
- Respiratory Tract Infections · Phase 3
- Spondylitis, Ankylosing · Phase 4
- Sprains and Strains · Phase 2
- Therapeutic Equivalency · Phase 1
- Wounds and Injuries · Phase 3
Mechanism of action
- CyclooxygenaseINHIBITOR
Cyclooxygenase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1- Mol. weight
- 246.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Prodrug
Sources
- ChEMBLCHEMBL19299 ↗
- WikipediaLoxoprofen ↗
- ChEMBLCHEMBL66552 ↗
Also known as
- 156-s
- 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid
- 2-ocppp
- cs 600
- cs-600
- loxonin
- loxoprofen
- loxoprofen
- loxoprofen
- loxoprofen
- loxoprofen
- loxoprofen
- loxoprofen
- loxoprofen
- loxoprofen alcohol
- loxoprofen sodium
- loxoprofen sodium
- loxoprofen sodium
- loxoprofen sodium dihydrate
- loxoprofen sodium hydrate
- loxoprofen sodium hydrate
- loxoprofen sodium hydrate
- loxoprofen sodium hydrate
- loxoprofen sodium hydrate
- loxoprofen sodium, (r*,s*)-isomer
- sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate dihydrate
- sodium loxoprofen
- sodium loxoprofen
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06047483 | Phase 2 | Oct 31, 2023 | Hengrui Therapeutics, Inc. |
| NCT04386122 | Phase 1 | May 7, 2020 | Hanoi Medical University |
| NCT03386149 | Phase 3 | Dec 28, 2017 | Daegu Haany University, Dongguk University, Kyung Hee University |
| NCT02983747 | N/A | Nov 1, 2016 | Second Military Medical University |
| NCT02831569 | Phase 3 | Jul 1, 2016 | Boehringer Ingelheim |
| NCT02602353 | Phase 2 | Oct 1, 2015 | Cardinal Health, Jean Brown Research, Lead Chemical Co.,Ltd. |
| NCT02616068 | Phase 3 | Oct 1, 2015 | Daiichi Sankyo, IQVIA |
| NCT02384928 | N/A | Sep 9, 2015 | Jaseng Hospital of Korean Medicine |
| NCT02467504 | Phase 2 | Jul 1, 2015 | Beijing Sl Pharma Co Ltd, Monash University, Peking University |
| NCT03800797 | Phase 4 | May 25, 2015 | Sun Yat-Sen University |
| NCT01922466 | Phase 2 | Jul 1, 2013 | Korea Institute of Oriental Medicine, Kyung Hee University |
| NCT01779271 | Phase 3 | Jan 1, 2013 | Daewon Pharmaceutical Co., Ltd. |
| NCT01491321 | Phase 2 | Apr 1, 2011 | Kyung Hee University |
| NCT00994461 | Phase 4 | Nov 1, 2009 | Pfizer |
| NCT00676117 | Phase 1 | Apr 1, 2008 | AstraZeneca, Osaka Pharmacology Clinical Research Hospital |
| NCT00141154 | Phase 3 | Oct 1, 2004 | Pfizer |
Showing 16 of 16 trials
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Organizations
Research & Development (22)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Kyung Hee University | Academic/Hospital | 3 | 3 | 2 | 2011 |
| Pfizer | For profit | 2 | 2 | 2 | 2004 |
| AstraZeneca | For profit | 1 | 1 | 1 | 2008 |
| Beijing Sl Pharma Co Ltd | For profit | 1 | 0 | 1 | 2015 |
| Boehringer Ingelheim | For profit | 1 | 1 | 1 | 2016 |
| Cardinal Health | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Daegu Haany University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Daewon Pharmaceutical Co., Ltd. | For profit | 1 | 1 | 1 | 2013 |
| Daiichi Sankyo | For profit | 1 | 1 | 1 | 2015 |
| Dongguk University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Hanoi Medical University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Hengrui Therapeutics, Inc. | For profit | 1 | 1 | 1 | 2023 |
| IQVIA | For profit | 1 | 0 | 1 | 2015 |
| Jaseng Hospital of Korean Medicine | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Jean Brown Research | For profit | 1 | 0 | 1 | 2015 |
| Korea Institute of Oriental Medicine | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Lead Chemical Co.,Ltd. | For profit | 1 | 1 | 1 | 2015 |
| Monash University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Osaka Pharmacology Clinical Research Hospital | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2015 |
22 organizations
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