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somatostatin

Recombinant proteinexperimental

Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion. — Wikipedia

Clinical trial activity

48 trials · 78 clinical orgs · 0 marketing orgs

Phase 1
8
Phase 2
14
Phase 3
12
Phase 4
12

Earliest trial started Jul 1, 1999 (NCT00431665)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2000

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2010

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C[C@H](N)C(=O)NCC(=O)N[C@H]1CSSC[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O
Mol. weight
1637.91 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Multi-specific
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • aminopan
  • growth hormone release-inhibiting factor
  • somatostatin
  • somatostatin
  • somatostatin
  • somatostatin
  • somatostatin
  • somatostatin
  • somatostatin
  • somatostatin
  • somatostatin
  • somatotropin release-inhibiting hormone
  • srif-14
  • srif-14
  • srif-14

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07304466N/ADec 29, 2025Istanbul Medipol University
NCT07252401N/ADec 25, 2025People's Liberation Army of China
NCT06416969Early Phase 1 (Phase 1)Oct 1, 2024Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT06855095Phase 2/Phase 3 (Phase 3)Jun 25, 2024Netherlands Cancer Institute
NCT06135168Phase 1Dec 10, 2023GeneScience Pharmaceuticals Co., Ltd.
NCT06135155Phase 1Nov 24, 2023GeneScience Pharmaceuticals Co., Ltd.
NCT05701241Phase 4Jun 28, 2023Erasmus University Rotterdam, Katholieke Universiteit Leuven, University of Antwerp, ZonMw: The Netherlands Organisation for Health Research and Development
NCT05838885Phase 2Feb 15, 2022Huazhong University of Science and Technology, Xiamen Amoytop Biotech Co., Ltd.
NCT03998293Phase 4Jun 1, 2020Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04107428Phase 4Dec 31, 2019CEINGE - Biotecnologie Avanzate, Napoli, Italia, King Faisal University, University of Naples Frederico II
NCT03998709Phase 4Oct 1, 2019Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT04010669Phase 3Aug 1, 2019University of Athens
NCT04329039Phase 2/Phase 3 (Phase 3)Jul 16, 2019Mayo Clinic
NCT04358016Phase 4Jan 1, 2018Changhai Hospital, Jiao Tong University
NCT03349424Phase 4Dec 31, 2017Chinese Academy of Medical Sciences
NCT03241706Phase 1Sep 1, 2017University of Cincinnati
NCT02705651Phase 3Jun 1, 2017University of Vienna
NCT03000946Phase 3Feb 1, 2017University of Paris
NCT02836353N/AJan 1, 2017University of Cambridge
NCT02799212Phase 3Jan 1, 2017University of Lyon
Showing 20 of 48 trials
Page 1 / 3

Organizations

Research & Development (78)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Mayo ClinicAcademic/Hospital6642014
People's Liberation Army of ChinaGovernment5332009
Jiao Tong UniversityAcademic/Hospital4132009
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government4032016
Aarhus UniversityAcademic/Hospital2212008
Capital Medical UniversityAcademic/Hospital2022009
Changhai HospitalAcademic/Hospital2222011
Eastern Hepatobiliary Surgery HospitalAcademic/Hospital2022009
GeneScience Pharmaceuticals Co., Ltd.For profit2212023
Huazhong University of Science and TechnologyAcademic/Hospital2022011
Korea UniversityAcademic/Hospital2222006
University of ViennaAcademic/Hospital2221999
Association for Innovation and Biomedical Research on Light and Image (AIBILI)Academic/Hospital1012013
BCN PeptidesFor profit1112013
CEINGE - Biotecnologie Avanzate, Napoli, ItaliaAcademic/Hospital1012019
China Medical UniversityAcademic/Hospital1012009
Chinese Academy of Medical SciencesAcademic/Hospital1112017
Chongqing Medical UniversityAcademic/Hospital1012009
Dalian Medical UniversityAcademic/Hospital1012009
Deutsche Krebshilfe e.V.Academic/Hospital1011999
78 organizations
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