CDEK
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tropifexor

Small moleculeexperimental

Clinical trial activity

8 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
6
Phase 3
0
Phase 4
0

Earliest trial started Sep 9, 2015 (NCT02516605)

Timeline

2010s

  1. Jan 1, 2015

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2018

    Earliest Phase 1 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

O=C(O)c1cc(F)c2nc(N3[C@@H]4CC[C@H]3C[C@@H](OCc3c(-c5ccccc5OC(F)(F)F)noc3C3CC3)C4)sc2c1
Mol. weight
603.59 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • ljn452

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT04408937Phase 1Jul 13, 2020Novartis
NCT04147195Phase 2Jan 20, 2020Novartis
NCT04065841Phase 2Dec 10, 2019Novartis
NCT03681457Phase 1Sep 25, 2018Novartis
NCT03517540Phase 2Aug 10, 2018Allergan, Novartis
NCT02855164Phase 2Aug 1, 2016Novartis
NCT02713243Phase 2Apr 1, 2016Novartis
NCT02516605Phase 2Sep 9, 2015Novartis
Showing 8 of 8 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
NovartisFor profit8822015
AllerganFor profit1012018
2 organizations
Page 1 / 1