← Mechanisms of action
NR1H4
SINGLE PROTEINHomo sapiens
Preferred name: Bile acid receptor FXR ChEMBL ↗
Linked proteins
Drugs acting on this target (17)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| chenodeoxycholic acid (Chenix) | Agonist | approved | Small molecule | NR1H4 agonist |
| cilofexor | Agonist | experimental | Small molecule | NR1H4 agonist |
| edp 305 | Agonist | experimental | Small molecule | NR1H4 agonist |
| edp-297 | Agonist | experimental | Small molecule | NR1H4 agonist |
| edp-305 | Agonist | experimental | Small molecule | NR1H4 agonist |
| hpg1860 | Agonist | experimental | Small molecule | NR1H4 agonist |
| int-787 | Agonist | experimental | Small molecule | FXR |
| met642 | Agonist | experimental | Small molecule | NR1H4 agonist |
| Nidufexor | Agonist | experimental | Small molecule | Bile acid receptor FXR agonist |
| obeticholic acid (ocaliva) | Agonist | approved | Small molecule | NR1H4 agonist |
| px-104 | Agonist | experimental | Small molecule | NR1H4 agonist |
| ter-101 | Agonist | experimental | Small molecule | NR1H4 agonist |
| tern-101 | Agonist | experimental | Small molecule | Bile acid receptor FXR agonist |
| tropifexor | Agonist | experimental | Small molecule | Bile acid receptor FXR agonist |
| turofexorate isopropyl | Agonist | experimental | Small molecule | NR1H4 agonist |
| ursodeoxycholic acid | Agonist | approved | Small molecule | NR1H4 agonist |
| tern-101 | Inhibitor | experimental | Small molecule | NR1H4 inhibitor |