abt-751
Small moleculeexperimental
Clinical trial activity
12 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
9
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2002 (NCT00036959)
Timeline
Indications
Studied for
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- Carcinoma, Renal Cell · Phase 2
- Colorectal Neoplasms · Phase 2
- Hematologic Neoplasms · Phase 1
- Kidney Neoplasms · Phase 1
- Leukemia, Lymphoid · Phase 1
- Liver Neoplasms · Phase 1
- Lung Neoplasms · Phase 1/Phase 2
- Neoplasms · Phase 1
- Neuroblastoma · Phase 2
- Ovarian Neoplasms · Phase 1
- Pediatrics · Phase 1
- Precursor Cell Lymphoblastic Leukemia-Lymphoma · Phase 1
- Prostatic Neoplasms · Phase 1/Phase 2
- Sarcoma · Phase 1
Mechanism of action
- TubulinINHIBITOR
Tubulin inhibitor
- Tubulin beta-4B chain (TUBB4B) ↗
- Tubulin beta-1 chain (TUBB1) ↗
- Tubulin alpha-3C chain (TUBA3C) ↗
- Tubulin alpha-4A chain (TUBA4A) ↗
- Tubulin beta-3 chain (TUBB3) ↗
- Tubulin alpha-1A chain (TUBA1A) ↗
- Tubulin beta-4A chain (TUBB4A) ↗
- Tubulin beta-8 chain (TUBB8) ↗
- Tubulin beta chain (TUBB) ↗
- Tubulin alpha-1B chain (TUBA1B) ↗
- Tubulin alpha-1C chain (TUBA1C) ↗
- Tubulin alpha-3E chain (TUBA3E) ↗
- Tubulin beta-2A chain (TUBB2A) ↗
- Tubulin beta-2B chain (TUBB2B) ↗
- Tubulin beta-6 chain (TUBB6) ↗
- Tubulin betaINHIBITOR
Tubulin beta inhibitor
Colchicine site
- Tubulin beta-4B chain (TUBB4B) ↗
- Tubulin beta-1 chain (TUBB1) ↗
- Tubulin beta-3 chain (TUBB3) ↗
- Tubulin beta-4A chain (TUBB4A) ↗
- Tubulin beta-8 chain (TUBB8) ↗
- Tubulin beta chain (TUBB) ↗
- Tubulin beta-2A chain (TUBB2A) ↗
- Tubulin beta-2B chain (TUBB2B) ↗
- Tubulin beta-6 chain (TUBB6) ↗
- Tubulin beta-8 chain-like protein LOC260334 (TUBB8B) ↗
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc(S(=O)(=O)Nc2cccnc2Nc2ccc(O)cc2)cc1- Mol. weight
- 371.42 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL20684 ↗
Also known as
- abt751
- abt-751
- abt-751
- abt-751
- abt-751
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00354562 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2007 | Abbott |
| NCT00436852 | Phase 2 | Jan 1, 2007 | National Cancer Institute (NCI) |
| NCT00297089 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2006 | AbbVie |
| NCT00439296 | Phase 1 | May 1, 2006 | University of Southern California |
| NCT00735878 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2004 | Abbott, Dartmouth University |
| NCT00471718 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2004 | National Cancer Institute (NCI), Vanderbilt University |
| NCT00073151 | Phase 2 | Sep 1, 2003 | Abbott |
| NCT00073138 | Phase 2 | Aug 1, 2003 | Abbott |
| NCT00073112 | Phase 2 | Aug 1, 2003 | Abbott |
| NCT00047489 | Phase 1 | Dec 1, 2002 | University of Texas at Houston |
| NCT00063102 | Phase 2 | Nov 1, 2002 | Abbott |
| NCT00036959 | Phase 1 | Mar 1, 2002 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
Showing 12 of 12 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Abbott | For profit | 6 | 5 | 1 | 2002 |
| National Cancer Institute (NCI) | Government | 3 | 1 | 2 | 2002 |
| AbbVie | For profit | 1 | 1 | 1 | 2006 |
| Dartmouth University | Academic/Hospital | 1 | 1 | 1 | 2004 |
| National Institutes of Health (NIH) | Government | 1 | 1 | 1 | 2002 |
| University of Southern California | Academic/Hospital | 1 | 1 | 1 | 2006 |
| University of Texas at Houston | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Vanderbilt University | Academic/Hospital | 1 | 1 | 1 | 2004 |
8 organizations
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