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chloroprocaine

Trade name: nesacaine

Small moleculeapproved

Approved

Mar 11, 1955

Chloroprocaine, sold under the brand name Nesacaine among others is a local anesthetic given by injection. It is used as the hydrochloride salt. Chloroprocaine is a local anesthetic. — Wikipedia

Clinical trial activity

32 trials · 45 clinical orgs · 7 marketing orgs

Phase 1
2
Phase 2
11
Phase 3
5
Phase 4
16

Earliest trial started Jan 1, 2008 (NCT02287870)

Timeline

1950s

  1. Mar 11, 1955

    Fresenius — Earliest FDA Approval

  2. Mar 11, 1955

    Fresenius — NDA Organization

  3. Mar 11, 1955

    Fresenius — NDA Secondary Org

1980s

  1. Apr 16, 1982

    Hospira — Marketing Organization

1990s

  1. Sep 9, 1998

    West-Ward Pharmaceutical — Marketing Organization

  2. Sep 9, 1998

    Hikma — Marketing Organization

2010s

  1. Jan 1, 2015

    Sintetica SA — Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2015

    Sintetica SA — Earliest Phase 3 Sponsor(trial)

  3. Sep 26, 2017

    B. Braun — NDA Secondary Org

  4. Sep 26, 2017

    B. Braun — Marketing Organization

  5. Jan 1, 2018

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Sep 27, 2022

    Sintetica SA — Marketing Organization

  2. Sep 27, 2022

    Harrow Health — Marketing Organization

  3. Sep 27, 2022

    Harrow Health — NDA Secondary Org

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedPriority reviewMar 11, 1955

Chemistry & pharmacology

Loading structure…

SMILES

CCN(CC)CCOC(=O)c1ccc(N)cc1Cl
Mol. weight
270.76 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Parenteral, Topical
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

Yes

Sources

Also known as

  • 2-chloroprocaine
  • 2-chloroprocaine
  • 2-chloroprocaine
  • 2-chloroprocaine
  • 2-(diethylaminoethyl)-4-amino-2-chlorobenzoate
  • 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
  • 4-amino-2-chlorobenzoic acid 2-(diethylamino)ethyl ester
  • ampres
  • chloroprocain
  • chloroprocain
  • chloroprocain
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine
  • chloroprocaine hcl
  • chloroprocaine hcl
  • chloroprocaine hcl
  • chloroprocaine hydrochloride
  • chloroprocaine hydrochloride
  • chloroprocaine hydrochloride
  • chloroprocaine hydrochloride
  • chloroprocaine hydrochloride
  • chloroprocainum
  • chloroprocainum
  • chlorprocaine
  • chlorprocaine
  • chlorprocaine
  • chlor-procaine
  • chlorprocaine chloride
  • chlorprocaine chloride
  • cloroprocaina
  • cloroprocaina
  • halestyn
  • nesacaine
  • nesacaine
  • nesacaine
  • nesacaine
  • nesacaine mpf
  • nesacaine-mpf
  • nesacaine-mpf
  • piocaine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07239999Phase 4Jan 12, 2026Dalhousie University, Government of Canada
NCT06472232Phase 4Jun 18, 2024Capital Medical University, Jiao Tong University, Jiaxing Maternity and Child Health Care Hospital, Jilin University, Nanjing Medical University, Shengjing Hospital, Wenzhou Medical University, Xiamen University, Zhejiang University
NCT06302257Phase 4Mar 1, 2024Hebrew University
NCT05926258Phase 3Feb 29, 2024Cross Research S.A., Sintetica SA
NCT06376058N/AJan 10, 2024Aretaieion University
NCT05934253Phase 4Jul 15, 2023Harrow Health
NCT04685538Phase 3Sep 9, 2020Sintetica SA
NCT04369950Phase 4May 11, 2020University of Texas at Houston
NCT03760718Early Phase 1 (Phase 1)Sep 1, 2019Oregon Health and Science University
NCT03967288Phase 4Aug 1, 2019B. Braun, Oregon Health and Science University
NCT03993314Phase 2Jul 1, 2019University of Alabama, Birmingham
NCT03918798Phase 2Feb 14, 2019Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna, Sintetica SA
NCT03805438Phase 4Feb 7, 2019Duke University, University of Arkansas
NCT03260972Phase 3Dec 31, 2018Johns Hopkins University
NCT03365752Phase 2Jun 24, 2018Rockefeller University
NCT03428230Phase 2May 10, 2018Clinica Ars Medica, Gravesano, Switzerland, Cross Research S.A., Sintetica SA
NCT03414359Early Phase 1 (Phase 1)Feb 15, 2018University of Arkansas
NCT03324984Phase 2Nov 20, 2017Yeshiva University
NCT03305575Phase 4Oct 13, 2017Tufts University
NCT02726620N/AJan 1, 2017Utrecht University, Vanderbilt University
Showing 20 of 32 trials
Page 1 / 2

Organizations

Research & Development (45)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Sintetica SAFor profit7722015
Cross Research S.A.For profit5022015
Clinica Ars Medica, Gravesano, SwitzerlandAcademic/Hospital2022015
Ghent UniversityAcademic/Hospital2212013
Oregon Health and Science UniversityAcademic/Hospital2222019
University of ArkansasAcademic/Hospital2122018
Aml ResearchAcademic/Hospital1012016
Aretaieion UniversityAcademic/Hospital1112024
Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'AnnaAcademic/Hospital1012019
B. BraunFor profit1012019
Cabinet Médical ASTES, Clinique St-Luc de BougeAcademic/Hospital1112013
Capital Medical UniversityAcademic/Hospital1012024
Columbia UniversityAcademic/Hospital1112016
Dalhousie UniversityAcademic/Hospital1012026
Department of Veteran AffairsGovernment1012009
Duke UniversityAcademic/Hospital1112019
Free University of BrusselsAcademic/Hospital1112016
Government of CanadaGovernment1112026
Harrow HealthFor profit1112023
Hebrew UniversityAcademic/Hospital1112024
45 organizations
Page 1 / 3

Marketing (10)

OrganizationOrg typeRelationshipDate
B. BraunFor profitNDA2Sep 26, 2017
B. BraunFor profitMKTGSep 26, 2017
FreseniusFor profitNDAMar 11, 1955
FreseniusFor profitNDA2Mar 11, 1955
Harrow HealthFor profitMKTGSep 27, 2022
Harrow HealthFor profitNDA2Sep 27, 2022
HikmaFor profitMKTGSep 9, 1998
HospiraFor profitMKTGApr 16, 1982
Sintetica SAFor profitMKTGSep 27, 2022
West-Ward PharmaceuticalFor profitMKTGSep 9, 1998