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indocyanine green

Trade name: ic-green

Small moleculeapprovedImaging agent

Approved

Feb 9, 1959

ICG is a cyanine fluorescent dye which is used in medicine as an indicator substance (for photometric hepatic function diagnostics and fluorescence angiography) in cardiac, circulatory, hepatic and ophthalmic conditions. It is administered intravenously and, depending on liver performance, is eliminated from the body with a half life of approx. 3-4 minutes. — NCATS

Clinical trial activity

226 trials · 176 clinical orgs · 5 marketing orgs

Phase 1
74
Phase 2
73
Phase 3
22
Phase 4
25

Earliest trial started Dec 1, 1996 (NCT00540982)

Timeline

1950s

  1. Feb 9, 1959

    Akorn, Inc. — Earliest FDA Approval

  2. Feb 9, 1959

    Akorn, Inc. — NDA Secondary Org

  3. Feb 9, 1959

    Akorn, Inc. — NDA Organization

2000s

  1. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

  2. Nov 21, 2007

    Renew Group — Marketing Organization

  3. Nov 21, 2007

    Diagnostic Green — Marketing Organization

2010s

  1. Jan 1, 2010

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2013

    Earliest Phase 3 Sponsor(trial)

  3. Nov 21, 2018

    Novadaq Technologies Inc. — NDA Secondary Org

  4. Nov 21, 2018

    Stryker — NDA Secondary Org

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedPriority reviewFeb 9, 1959

Chemistry & pharmacology

Loading structure…

SMILES

CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccc3ccccc3c21
Mol. weight
754.01 g/mol
Lipinski Ro5
2 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Availability
Prescription Only

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 4,5-benzoindotricarbocyanine
  • cardio-green
  • cardio-green
  • fox green
  • fox green
  • ic-green
  • ic-green
  • ic-green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green
  • indocyanine green sodium
  • indocyanine green sodium
  • indocyanine green sodium
  • indocyanin green
  • indocyanin green
  • indocyanin green
  • infracyanine
  • lft-0002
  • opthagreen
  • sodium 4-(2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1h-benzo[e]indolium-2-yl]hepta-2,4,6-trien-1-ylidene}-1,1-dimethyl-1,2-dihydro-3h-benzo[e]indol-3-yl)butane-1-sulfonate
  • sodium 4-(2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1h-benzo[e]indolium-2-yl]hepta-2,4,6-trien-1-ylidene}-1,1-dimethyl-1,2-dihydro-3h-benzo[e]indol-3-yl)butane-1-sulfonate
  • wofaverdin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07149207Phase 2Jan 1, 2026Medical University of South Carolina
NCT07295262Early Phase 1 (Phase 1)Jan 1, 2026Sichuan University
NCT07250854Early Phase 1 (Phase 1)Dec 31, 2025University of Alabama, Birmingham
NCT07254845Phase 1Dec 1, 2025VPIX Medical
NCT07195331Phase 4Oct 15, 2025Spanish Association of Surgeons (AEC), University of Salamanca
NCT07144904Phase 4Oct 1, 2025Baylor University
NCT07165340Phase 1/Phase 2 (Phase 2)Sep 30, 2025Tactile Medical, University of Texas at Houston
NCT06871787Phase 4Sep 1, 2025Istanbul University
NCT07108855Phase 1/Phase 2 (Phase 2)Sep 1, 2025University of Groningen
NCT06672224N/AAug 14, 2025City of Hope National Medical Center, National Cancer Institute (NCI)
NCT07060443Phase 2Jul 23, 2025Pusan National University
NCT06867978Phase 1Jun 1, 2025VPIX Medical
NCT07146295N/AApr 18, 2025Alrijne Hospital, Canisius-Wilhelmina Hospital, Dijklander Ziekenhuis, Noordwest Ziekenhuisgroep, Spaarne Gasthuis, St. Antonius Hospital, Nieuwegein, University of Twente, Utrecht University, ZonMw: The Netherlands Organisation for Health Research and Development
NCT06831149Phase 2Feb 28, 2025University of Pittsburgh
NCT06437054Phase 1/Phase 2 (Phase 2)Feb 15, 2025Seoul National University
NCT06994949Phase 1Jan 14, 2025National Institute of Neurological Disorders and Stroke (NINDS), University of Texas at Houston
NCT06840418N/AJan 1, 2025Fudan University
NCT06755554Phase 3Jan 1, 2025Ukrainian Society of Clinical Oncology
NCT06327490Phase 2Oct 31, 2024University of Florida
NCT06610071Phase 1Oct 30, 2024Chinese Academy of Medical Sciences
Showing 20 of 226 trials
Page 1 / 12

Organizations

Research & Development (176)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Cancer Institute (NCI)Government17041996
University of Texas at HoustonAcademic/Hospital131232010
Free University of BrusselsAcademic/Hospital111132013
Harvard UniversityAcademic/Hospital9932010
University of PennsylvaniaAcademic/Hospital8822011
University of TorontoAcademic/Hospital7642012
Fujian Medical UniversityAcademic/Hospital6632017
Chinese Academy of Medical SciencesAcademic/Hospital5522013
Ohio State UniversityAcademic/Hospital5522013
City of Hope National Medical CenterAcademic/Hospital4421996
National Institutes of Health (NIH)Government4022009
Southern Medical UniversityAcademic/Hospital4442016
Stanford UniversityAcademic/Hospital4422009
StrykerFor profit4042013
University of Western OntarioAcademic/Hospital4432016
Fudan UniversityAcademic/Hospital3322019
Huazhong University of Science and TechnologyAcademic/Hospital3312017
McMaster UniversityAcademic/Hospital3022016
Memorial Sloan-Kettering Cancer CenterAcademic/Hospital3322018
National Cancer Center, KoreaGovernment3312015
176 organizations
Page 1 / 9

Marketing (6)

OrganizationOrg typeRelationshipDate
Akorn, Inc.For profitNDA2Feb 9, 1959
Akorn, Inc.For profitNDAFeb 9, 1959
Diagnostic GreenFor profitMKTGNov 21, 2007
Novadaq Technologies Inc.For profitNDA2Nov 21, 2018
Renew GroupFor profitMKTGNov 21, 2007
StrykerFor profitNDA2Nov 21, 2018