acetylcholine chloride

Trade name: miochol

Small moleculeapproved

Approved

Oct 9, 1973

Acetylcholine is the neurotransmitter at neuromuscular junctions, at synapses in the ganglia of the visceral motor system, and at a variety of sites within the central nervous system. Whereas a great deal is known about the function of cholinergic transmission at the neuromuscular junction and at ganglionic synapses, the actions of acetylcholine in the central nervous system are not as well understood. Cholinergic system is an important system and a branch of the autonomic nervous system which plays an important role in memory, digestion, control of heart beat, blood pressure, movement and many other functions. Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission, induces synaptic plasticity, and coordinates firing of groups of neurons. Miochol®-E (acetylcholine chloride intraocular solution) is used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required. — NCATS

Clinical trial activity

39 trials · 31 clinical orgs · 2 marketing orgs

Phase 1
21
Phase 2
8
Phase 3
0
Phase 4
1

Earliest trial started Jan 1, 1996 (NCT00152724)

Timeline

1970s

  1. Oct 9, 1973

    Novartis — Earliest FDA Approval

  2. Oct 9, 1973

    Novartis — NDA Secondary Org

  3. Oct 9, 1973

    Novartis — NDA Organization

1990s

  1. Sep 22, 1993

    Bausch & Lomb — NDA Secondary Org

  2. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 1999

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Approval history

  • approvedOct 9, 1973

Chemistry & pharmacology

Loading structure…

SMILES

CC(=O)OCC[N+](C)(C)C
Mol. weight
146.21 g/mol
Lipinski Ro5
Pass
Rule of 3
Yes
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Topical
Availability
Prescription Only

Oral

No

Parenteral

No

Topical

Yes

Sources

Also known as

  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine
  • acetylcholine chloride
  • acetylcholine chloride
  • acetylcholine chloride
  • acetylcholine chloride
  • acetylcholine chloride
  • miochol
  • miochol
  • miochol
  • miochol-e
  • miochol-e
  • miphtel

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06499844Early Phase 1 (Phase 1)Aug 1, 2024University of Iowa
NCT05946798Early Phase 1 (Phase 1)Aug 30, 2023University of Iowa
NCT05219799Early Phase 1 (Phase 1)Feb 28, 2023University of Missouri
NCT05653973Early Phase 1 (Phase 1)Jan 3, 2023University of Iowa
NCT05193968N/AFeb 24, 2022Mayo Clinic, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH)
NCT05946785Early Phase 1 (Phase 1)Feb 1, 2021University of Iowa
NCT04918563N/ASep 15, 2020Semmelweis University
NCT04001647Early Phase 1 (Phase 1)Jun 1, 2019Colorado State University
NCT03953326Phase 1/Phase 2 (Phase 2)Apr 23, 2019Pennsylvania State University
NCT03972683Early Phase 1 (Phase 1)Apr 16, 2019Colorado State University
NCT04777383N/AApr 1, 2019Linkoping University
NCT03738943Early Phase 1 (Phase 1)Feb 7, 2019Colorado State University
NCT03446612Phase 2Oct 15, 2018GlaxoSmithKline
NCT03462017Phase 1Mar 7, 2018Sanofi
NCT01075776N/AJan 1, 2017University of London
NCT03376555Phase 1/Phase 2 (Phase 2)Mar 31, 2016National Dairy Council, Pennsylvania State University
NCT02034331N/ADec 1, 2012Department of Veteran Affairs
NCT01848301Phase 1Sep 1, 2012University of Pittsburgh
NCT01162824N/AJan 1, 2011University of London
NCT01125943N/AJun 1, 2010Dutch Cancer Society, Radboud University
Showing 20 of 39 trials
Page 1 / 2

Organizations

Research & Development (31)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Heart, Lung, and Blood Institute (NHLBI)Government7432003
National Institutes of Health (NIH)Government5332001
University of IowaAcademic/Hospital4412021
Colorado State UniversityAcademic/Hospital3312019
Radboud UniversityAcademic/Hospital3312005
Department of Veteran AffairsGovernment2122008
Pennsylvania State UniversityAcademic/Hospital2212016
University of LondonAcademic/Hospital2212011
University of PittsburghAcademic/Hospital2212010
Azienda Ospedaliera San Camillo ForlaniniAcademic/Hospital1112009
British Heart FoundationAcademic/Hospital1012010
Dutch Cancer SocietyAcademic/Hospital1012010
Emory UniversityAcademic/Hospital1112002
European Society of CardiologyAcademic/Hospital1012009
GlaxoSmithKlineFor profit1112018
Linkoping UniversityAcademic/Hospital1112019
Mayo ClinicAcademic/Hospital1112022
National Center for Complementary and Integrative Health (NCCIH)Government1111999
National Dairy CouncilAcademic/Hospital1012016
NHS LothianAcademic/Hospital1012010
31 organizations
Page 1 / 2

Marketing (3)

OrganizationOrg typeRelationshipDate
Bausch & LombFor profitNDA2Sep 22, 1993
NovartisFor profitNDA2Oct 9, 1973
NovartisFor profitNDAOct 9, 1973