nerispirdine
Small moleculeexperimental
Clinical trial activity
3 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2004 (NCT00093275)
Timeline
2000s
- Jan 1, 2004
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
Voltage-gated potassium channel blocker
- Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) ↗
- Potassium voltage-gated channel subfamily D member 3 (KCND3) ↗
- Potassium voltage-gated channel subfamily H member 2 (KCNH2) ↗
- Potassium voltage-gated channel subfamily A member 2 (KCNA2) ↗
- Potassium voltage-gated channel subfamily A member 1 (KCNA1) ↗
- Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) ↗
- Potassium voltage-gated channel subfamily KQT member 3 (KCNQ3) ↗
- Potassium voltage-gated channel subfamily A member 7 (KCNA7) ↗
- Potassium voltage-gated channel subfamily KQT member 5 (KCNQ5) ↗
- Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) ↗
- Potassium voltage-gated channel subfamily H member 1 (KCNH1) ↗
- Potassium voltage-gated channel subfamily A member 4 (KCNA4) ↗
- Potassium voltage-gated channel subfamily A member 5 (KCNA5) ↗
- Potassium voltage-gated channel subfamily A member 3 (KCNA3) ↗
- Potassium voltage-gated channel subfamily A member 6 (KCNA6) ↗
- Potassium voltage-gated channel subfamily C member 1 (KCNC1) ↗
- Potassium voltage-gated channel subfamily D member 2 (KCND2) ↗
- Potassium voltage-gated channel subfamily B member 2 (KCNB2) ↗
- Potassium voltage-gated channel subfamily C member 4 (KCNC4) ↗
- Potassium voltage-gated channel subfamily C member 3 (KCNC3) ↗
- Potassium voltage-gated channel subfamily B member 1 (KCNB1) ↗
- Potassium voltage-gated channel subfamily A member 10 (KCNA10) ↗
- Potassium voltage-gated channel subfamily V member 1 (KCNV1) ↗
- Potassium voltage-gated channel subfamily H member 5 (KCNH5) ↗
- Potassium voltage-gated channel subfamily G member 3 (KCNG3) ↗
- Potassium voltage-gated channel subfamily G member 4 (KCNG4) ↗
- Potassium voltage-gated channel subfamily V member 2 (KCNV2) ↗
- Potassium voltage-gated channel subfamily S member 1 (KCNS1) ↗
- Potassium voltage-gated channel subfamily H member 8 (KCNH8) ↗
- Potassium voltage-gated channel subfamily C member 2 (KCNC2) ↗
- Potassium voltage-gated channel subfamily S member 3 (KCNS3) ↗
- Potassium voltage-gated channel subfamily H member 6 (KCNH6) ↗
- Potassium voltage-gated channel subfamily F member 1 (KCNF1) ↗
- Potassium voltage-gated channel subfamily H member 7 (KCNH7) ↗
- Potassium voltage-gated channel subfamily D member 1 (KCND1) ↗
- Potassium voltage-gated channel subfamily G member 1 (KCNG1) ↗
- Potassium voltage-gated channel subfamily G member 2 (KCNG2) ↗
- Potassium voltage-gated channel subfamily H member 3 (KCNH3) ↗
- Potassium voltage-gated channel subfamily S member 2 (KCNS2) ↗
- Potassium voltage-gated channel subfamily H member 4 (KCNH4) ↗
- HERG
- Voltage-gated potassium channel subunit Kv1.5
- Voltage-gated potassium channel subunit Kv7.2
- Voltage-gated potassium channel subunit Kv1.2
- Voltage-gated potassium channel subunit Kv1.3
- Voltage-gated potassium channel subunit Kv7.4
- Voltage-gated potassium channel subunit Kv4.3
- Voltage-gated potassium channel subunit Kv1.7
- Voltage-gated potassium channel subunit Kv7.5
- Voltage-gated potassium channel subunit Kv1.1
- Voltage-gated potassium channel subunit Kv7.1
- Voltage-gated potassium channel subunit Kv7.3
- Voltage-gated potassium channel subunit Kv1.6
- Voltage-gated potassium channel subunit Kv3.1
- Voltage-gated potassium channel subunit Kv1.4
- Potassium voltage-gated channel subfamily D member 2
- Voltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3)
- Potassium voltage-gated channel subfamily B member 2
- Potassium voltage-gated channel subfamily B member 1
- Potassium voltage-gated channel subfamily C member 2
- Potassium voltage-gated channel subfamily H member 3
- KCNQ (Kv7) potassium channel
- Voltage-gated potassium channel KCNQ3/KCNQ4
- Voltage-gated potassium channel KCNQ3/KCNQ5
- KCNQ4/KCNQ5
- Voltage-gated potassium channel subunit Kv10.1
- Potassium voltage-gated channel subfamily A member 10
- Potassium voltage-gated channel subfamily H member 6
- Sodium channel alpha subunitBLOCKER
Sodium channel alpha subunit blocker
- Sodium channel protein type 1 subunit alpha (SCN1A) ↗
- Sodium channel protein type 5 subunit alpha (SCN5A) ↗
- Sodium channel protein type 4 subunit alpha (SCN4A) ↗
- Sodium channel protein type 7 subunit alpha (SCN7A) ↗
- Sodium channel protein type 2 subunit alpha (SCN2A) ↗
- Sodium channel protein type 9 subunit alpha (SCN9A) ↗
- Sodium channel protein type 3 subunit alpha (SCN3A) ↗
- Sodium channel protein type 11 subunit alpha (SCN11A) ↗
- Sodium channel protein type 8 subunit alpha (SCN8A) ↗
- Sodium channel protein type 10 subunit alpha (SCN10A) ↗
- Sodium channel protein type I alpha subunit
- Sodium channel protein type V alpha subunit
- Sodium channel protein type IV alpha subunit
- Sodium channel protein type VII alpha subunit
- Sodium channel protein type IX alpha subunit
- Sodium channel protein type II alpha subunit
- Sodium channel protein type III alpha subunit
- Sodium channel protein type XI alpha subunit
- Sodium channel protein type VIII alpha subunit
- Sodium channel protein type X alpha subunit
- Sodium channel alpha subunits; brain (Types I, II, III)
Chemistry & pharmacology
Loading structure…
SMILES
CCCN(c1ccncc1F)n1cc(C)c2ccccc21- Mol. weight
- 283.35 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2107762 ↗
Also known as
- hp184
- hp184
- hp 184
- hp-184
- hp-184
- hp-184
- nerispirdine
- nerispirdine
- nerispirdine
- nerispirdine
- nerispirdine
- n-(n-propyl)-3-fluoro-4-pyridinyl-1h-3-methylindol-1-amine hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00811902 | Phase 2 | Dec 1, 2008 | Sanofi |
| NCT00772525 | Phase 2 | Sep 1, 2008 | Sanofi, Thomas Jefferson University |
| NCT00093275 | Phase 2 | Oct 1, 2004 | Sanofi |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Sanofi | For profit | 3 | 3 | 1 | 2004 |
| Thomas Jefferson University | Academic/Hospital | 1 | 0 | 1 | 2008 |
2 organizations
Page 1 / 1