methylscopolamine bromide

Small moleculeapproved

Approved

Apr 9, 1953

Methscopolamine bromide is an anticholinergic agent used along with other medications to treat peptic ulcers by reducing stomach acid secretion. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications. Methscopolamine binds to M1-M5 isoforms of muscarinic receptors. — NCATS

Clinical trial activity

2 trials · 2 clinical orgs · 10 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Sep 1, 2005 (NCT00153751)

Timeline

1950s

Apr 9, 1953
Earliest FDA Approval
Apr 9, 1953
Fougera — NDA Secondary Org

1970s

Oct 18, 1976
Mylan — Marketing Organization

2000s

Jan 1, 2005
Earliest Phase 2 Sponsor(trial)
Dec 28, 2006
Vintage — Marketing Organization
Dec 28, 2006
Strides Pharma Science — Marketing Organization
Dec 28, 2006
Chartwell Pharmaceuticals — Marketing Organization

2010s

Dec 6, 2011
Esteve Labs — Marketing Organization
Sep 24, 2012
Bayshore Pharms Llc — Marketing Organization
Sep 24, 2012
Unichem — Marketing Organization
Jan 1, 2019
Earliest Phase 3 Sponsor(trial)

2020s

Feb 1, 2024
Nephron Pharmaceuticals Corporation — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Muscarinic acetylcholine receptor M1ANTAGONIST
CHRM1 antagonist
Role in regulating gastric secretion, M1 likely involved
- Muscarinic acetylcholine receptor M1 (CHRM1) ↗
Muscarinic acetylcholine receptor M3ANTAGONIST
CHRM3 antagonist
Role in regulating gastric secretion, M3 likely involved
- Muscarinic acetylcholine receptor M3 (CHRM3) ↗

Approval history

approvedApr 9, 1953

Chemistry & pharmacology

Loading structure…

SMILES

C[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12.[Br-]

Mol. weight: 398.3 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Prescription Only

Oral

Yes

Parenteral

Topical

Sources

Also known as

epoxytropine tropate methylbromide
epoxytropine tropate methylbromide
hyoscine methobromide
hyoscine methobromide
hyoscine methobromide
hyoscine methyl bromide
hyoscine methyl bromide
methscopolamine
methscopolamine
methscopolamine
methscopolamine
methscopolamine
methscopolamine
methscopolamine
methscopolamine
methscopolamine bromide
methscopolamine bromide
methscopolamine bromide
methscopolamine bromide
methscopolamine bromide
methscopolamine nitrate
methylscopolamine
methylscopolamine
methylscopolamine
methylscopolamine
methylscopolamine
methylscopolamine bromide
methylscopolamine bromide
methylscopolamine bromide
methylscopolamine bromide
methylscopolamine bromide
n-methylhyoscine
n-methylhyoscine bromide
n-methylhyoscine bromide
n-methylscopolamine
n-methylscopolamine methylsulfate
n-methylscopolamine methylsulfate
n-methylscopolammonium bromide
n-methylscopolammonium bromide
pamine
pamine
pamine
pamine
pamine forte
pamine forte
(−)-scopolamine methobromide
(−)-scopolamine methobromide
scopolamine methobromide
scopolamine methobromide
(−)-scopolamine methyl bromide
(−)-scopolamine methyl bromide
scopolamine methylbromide
scopolamine methylbromide
scopolamine methyl bromide
scopolamine methyl bromide

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT03961165	Phase 3	May 25, 2019	University of Oslo
NCT00153751	Phase 2	Sep 1, 2005	Chinese University of Hong Kong

Showing 2 of 2 trials

Page 1 / 1

Organizations

Research & Development (2)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Chinese University of Hong Kong	Academic/Hospital	1	1	1	2005
University of Oslo	Academic/Hospital	1	1	1	2019

2 organizations

Page 1 / 1

Marketing (10)

Organization	Org type	Relationship	Date
Bayshore Pharms Llc	For profit	MKTG	Sep 24, 2012
Chartwell Pharmaceuticals	For profit	MKTG	Dec 28, 2006
Esteve Labs	For profit	MKTG	Dec 6, 2011
Fougera	For profit	NDA2	Apr 9, 1953
Mylan	For profit	MKTG	Oct 18, 1976
Nephron Pharmaceuticals Corporation	For profit	MKTG	Feb 1, 2024
Strides Pharma Science	For profit	MKTG	Dec 28, 2006
Unichem	For profit	MKTG	Sep 24, 2012
Upjohn	For profit	NDA	—
Vintage	For profit	MKTG	Dec 28, 2006