fispemifene
Small moleculeexperimental
Fispemifene is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was developed for the treatment of male hypogonadism but was abandoned and never marketed. It reached phase II clinical trials for this indication before development was terminated in March 2016. The drug failed to achieve statistical significance on key effectiveness endpoints in clinical trials and was discontinued by its developer for strategic reasons. — Wikipedia
Clinical trial activity
4 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2006 (NCT00290134)
Timeline
2000s
- Jan 1, 2006
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
- Estrogen receptorMODULATOR
Estrogen receptor modulator
selective estrogen modulator (SERM)
Chemistry & pharmacology
Loading structure…
SMILES
OCCOCCOc1ccc(/C(=C(/CCCl)c2ccccc2)c2ccccc2)cc1- Mol. weight
- 422.95 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- WikipediaFispemifene ↗
- ChEMBLCHEMBL2107341 ↗
Also known as
- fispemifene
- fispemifene
- fispemifene
- fispemifene
- hm-101
- hm-101
- hm-101a
- hm-101a
- (z)-2-(2-(4-(4-chloro-1,2-diphenylbut-1-enyl)phenoxy)ethoxy)ethanol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02443090 | Phase 2 | May 1, 2015 | Apricus Biosciences |
| NCT01061970 | Phase 2 | Jan 1, 2007 | Hormos Medical, Quatrx Pharmaceuticals Co |
| NCT00415571 | Phase 2 | Dec 1, 2006 | Hormos Medical, Quatrx Pharmaceuticals Co |
| NCT00290134 | Phase 2 | Feb 1, 2006 | Hormos Medical, Quatrx Pharmaceuticals Co |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Hormos Medical | For profit | 3 | 0 | 1 | 2006 |
| Quatrx Pharmaceuticals Co | For profit | 3 | 3 | 1 | 2006 |
| Apricus Biosciences | For profit | 1 | 1 | 1 | 2015 |
3 organizations
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