sodium dichloroacetate
Small moleculeexperimental
Dichloroacetic acid (DCA), sometimes called bichloroacetic acid (BCA), is the organic compound with formula CHCl2CO2H. It is an analogue of acetic acid, in which 2 of the 3 hydrogen atoms of the methyl group have been replaced by chlorine atoms. Like the other chloroacetic acids, it has various practical applications. The salts and esters of dichloroacetic acid are called dichloroacetates. — Wikipedia
Clinical trial activity
32 trials · 28 clinical orgs · 0 marketing orgs
Phase 1
11
Phase 2
11
Phase 3
5
Phase 4
3
Earliest trial started Sep 1, 1998 (NCT00004493)
Timeline
Indications
Approved for
Studied for
- Acidosis, Lactic · Phase 3
- Brain Neoplasms · Phase 1
- Breast Neoplasms · Phase 2
- Cervical Intraepithelial Neoplasia · Phase 2/Phase 3
- Condylomata Acuminata · Phase 4
- Deficiency Diseases · Phase 3
- Diabetes Mellitus · Early Phase 1
- Diabetes Mellitus, Type 1 · Early Phase 1
- Glioblastoma · Phase 2
- Glioma · Phase 2
- Head and Neck Neoplasms · Phase 1
- Healthy Volunteers · Phase 1/Phase 2
- Heart Diseases · Phase 2
- Hypertension, Pulmonary · Phase 1
- Hypoglycemia · Early Phase 1
- Insulin Resistance · Phase 4
- Lentigo · Phase 4
- Lung Neoplasms · Phase 2
- MELAS Syndrome · Phase 2
- Neoplasms · Phase 1
- Nerve Sheath Neoplasms · Phase 4
- Pyruvate Dehydrogenase Complex Deficiency Disease · Phase 3
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Trichloroacetic Acid · Phase 2/Phase 3
- Warts · Phase 2/Phase 3
Mechanism of action
- Pyruvate dehydrogenase kinaseINHIBITOR
Pyruvate dehydrogenase kinase inhibitor
Stimulates oxidative phosphorylation through inhibition of pyruvate dehydrogenase kinase (PDK). By inhibiting PDK, piruvate dehydrogenase (PDH) is then maintained in a catalytically active state, mitochondrial pyruvate consumption is increased, the substrate pool available for glycolysis is lowered and lactic acid production is inhibited. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling.
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2) ↗
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) ↗
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (PDK4) ↗
- [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) ↗
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)C(Cl)Cl- Mol. weight
- 128.94 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaDichloroacetic acid ↗
- NCATSQ1LS2UJO3A ↗
- ChEMBLCHEMBL306823 ↗
- ChEMBLCHEMBL13960 ↗
Also known as
- bichloroacetic acid
- ceresine
- ceresine
- ceresine
- ceresine
- cmi x-11s
- cpc 211
- cpc-211
- cpc-211
- dca
- dca
- dca
- dichloracetic acid
- dichloracetic acid
- dichlorethanoic acid
- dichloroacetate
- dichloroacetate
- dichloroacetate
- dichloroacetate sodium
- dichloroacetate sodium
- dichloroacetic acid
- dichloroacetic acid
- dichloroacetic acid
- dichloroacetic acid
- dichloroacetic acid
- dichloroacetic acid
- dichloroacetic acid
- potassium dichloroacetate
- sodium dichloroacetate
- sodium dichloroacetate
- sodium dichloroacetate
- sodium dichloroacetate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06188104 | Phase 2/Phase 3 (Phase 3) | Nov 30, 2023 | Rajavithi Hospital, Bangkok |
| NCT05317455 | Early Phase 1 (Phase 1) | Jan 31, 2023 | Yale University |
| NCT05471947 | Phase 4 | Sep 1, 2022 | Main Line Center for Laser Surgery |
| NCT06281353 | Phase 2/Phase 3 (Phase 3) | Aug 16, 2022 | University of Indonesia |
| NCT05120284 | Phase 2 | Mar 31, 2022 | Food and Drug Administration, University of Florida |
| NCT04046081 | N/A | Sep 1, 2019 | Ferring, University of Birmingham, University of Edinburgh, University of Nottingham |
| NCT05594316 | N/A | May 1, 2019 | Al Azhar University |
| NCT03356457 | Early Phase 1 (Phase 1) | Nov 30, 2017 | Yale University |
| NCT02616484 | Phase 3 | Jul 29, 2017 | Columbia University, Medosome Biotec LLC, University of Florida |
| NCT02690285 | Phase 1 | Mar 1, 2016 | Food and Drug Administration, Medosome Biotec LLC, University of Florida |
| NCT01807702 | Phase 1 | Mar 1, 2013 | University of Florida |
| NCT02469337 | Phase 4 | May 1, 2012 | University of Nottingham |
| NCT00865514 | N/A | Aug 1, 2011 | University of Florida |
| NCT01386632 | Phase 2 | May 1, 2011 | Sanford Health |
| NCT01123005 | Phase 1 | Dec 31, 2010 | Stanford University |
| NCT01163487 | Phase 1 | Aug 1, 2010 | Stanford University |
| NCT01128270 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2010 | National Institutes of Health (NIH), University of Florida |
| NCT01111097 | Phase 1 | Apr 1, 2010 | National Institutes of Health (NIH), University of Florida |
| NCT01083524 | Phase 1 | Mar 1, 2010 | University of Alberta, University of London |
| NCT01029925 | Phase 2 | Dec 1, 2009 | University of California, Los Angeles |
Showing 20 of 32 trials
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Organizations
Research & Development (28)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Florida | Academic/Hospital | 11 | 11 | 4 | 1998 |
| University of Alberta | Academic/Hospital | 4 | 2 | 2 | 2007 |
| National Institutes of Health (NIH) | Government | 3 | 1 | 2 | 2000 |
| Columbia University | Academic/Hospital | 2 | 0 | 2 | 2000 |
| Food and Drug Administration | Government | 2 | 0 | 2 | 2016 |
| Medosome Biotec LLC | For profit | 2 | 0 | 2 | 2016 |
| Stanford University | Academic/Hospital | 2 | 2 | 1 | 2010 |
| University of Calgary | Academic/Hospital | 2 | 2 | 1 | 2007 |
| University of Nottingham | Academic/Hospital | 2 | 1 | 2 | 2012 |
| Yale University | Academic/Hospital | 2 | 2 | 1 | 2017 |
| Al Azhar University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| AnovoRx | For profit | 1 | 0 | 1 | — |
| Ferring | For profit | 1 | 0 | 1 | 2019 |
| Government of Canada | Government | 1 | 0 | 1 | 2007 |
| Main Line Center for Laser Surgery | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Rajavithi Hospital, Bangkok | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Sanford Health | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Saol Therapeutics | For profit | 1 | 1 | 1 | — |
| St. Vincents Hospital Manhattan | Academic/Hospital | 1 | 0 | 1 | 2006 |
| University of Birmingham | Academic/Hospital | 1 | 0 | 1 | 2019 |
28 organizations
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