evogliptin
Trade name: Suganon
Small moleculeexperimental
Evogliptin is an antidiabetic drug in the dipeptidyl peptidase-4 (DPP-4) inhibitor or "gliptin" class of drugs. It was developed by the South Korean pharmaceutical company Dong-A ST and is approved for use in South Korea and Russia. In a meta-analysis involving data from 6 randomized controlled trials, Dutta et. al. demonstrated the good glycaemic efficacy and safety of this medicine as compared to other DPP4 inhibitors like sitagliptin and linagliptin. — Wikipedia
Clinical trial activity
31 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
16
Phase 2
7
Phase 3
5
Phase 4
7
Earliest trial started May 1, 2009 (NCT00961025)
Timeline
Indications
Approved for
Studied for
- Albuminuria · Phase 2
- Aortic Valve Disease · Phase 2/Phase 3
- Bone Diseases, Metabolic · Phase 4
- Diabetes Mellitus · Phase 4
- Diabetes Mellitus, Type 2 · Phase 4
- Endocrine System Diseases · Phase 4
- Healthy Volunteers · Phase 1
- Hemodialysis, Home · Phase 1
- Hepatitis B, Chronic · Phase 4
- Kidney Diseases · Phase 4
- Kidney Failure, Chronic · Phase 1
- Liver Cirrhosis · Phase 4
- Liver Diseases · Phase 1
- Metabolic Diseases · Phase 4
- Non-alcoholic Fatty Liver Disease · Phase 4
- Osteoporosis · Phase 4
- Renal Insufficiency · Phase 2
- Vas Deferens · Phase 4
Mechanism of action
- Dipeptidyl peptidase 1INHIBITOR
CTSC inhibitor
- Dipeptidyl peptidase IVINHIBITOR
Dipeptidyl peptidase IV inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F- Mol. weight
- 401.43 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaEvogliptin ↗
- ChEMBLCHEMBL1779710 ↗
Also known as
- 4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one
- da1229
- da 1229
- da-1229
- da-1229
- da-1229
- evogliptin
- evogliptin
- evogliptin
- evogliptin
- evogliptin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07297940 | Phase 1 | Dec 31, 2025 | Dong-A Pharmaceutical |
| NCT05739916 | Phase 1 | Mar 30, 2023 | Dong-A Pharmaceutical |
| NCT05739903 | Phase 1 | Mar 25, 2023 | Dong-A Pharmaceutical |
| NCT05739851 | Phase 1 | Mar 18, 2023 | Dong-A Pharmaceutical |
| NCT05739877 | Phase 1 | Mar 17, 2023 | Dong-A Pharmaceutical |
| NCT05143177 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2021 | Mayo Clinic, REDNVIA |
| NCT04706637 | Phase 4 | Feb 1, 2021 | Dong-A Pharmaceutical, Kyung Hee University |
| NCT04653779 | Phase 4 | Dec 31, 2020 | Dong-A Pharmaceutical |
| NCT04521452 | Phase 4 | Sep 30, 2020 | REDNVIA, University of Ulsan |
| NCT05473806 | Phase 4 | Sep 18, 2020 | Yonsei University |
| NCT04356742 | Phase 3 | Apr 30, 2020 | Dong-A Pharmaceutical |
| NCT04195919 | Phase 1 | Dec 20, 2019 | Dong-A Pharmaceutical |
| NCT04170998 | Phase 3 | Nov 14, 2019 | Dong-A Pharmaceutical |
| NCT04055883 | Phase 2 | Aug 22, 2019 | Dong-A Pharmaceutical |
| NCT03910361 | Phase 4 | Apr 12, 2019 | Dong-A Pharmaceutical, Yonsei University |
| NCT03766724 | Phase 1 | Nov 22, 2018 | Dong-A Pharmaceutical, Yonsei University |
| NCT03667300 | Phase 2 | Mar 16, 2017 | Sungkyunkwan University |
| NCT02689362 | Phase 2 | Mar 1, 2017 | Eurofarma Laboratorios S.A. |
| NCT02954822 | Phase 1 | Nov 1, 2016 | Dong-A Pharmaceutical |
| NCT02974504 | Phase 4 | Sep 1, 2016 | Dong-A Pharmaceutical |
Showing 20 of 31 trials
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Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Dong-A Pharmaceutical | For profit | 25 | 24 | 4 | 2009 |
| Yonsei University | Academic/Hospital | 3 | 1 | 2 | 2018 |
| REDNVIA | For profit | 2 | 1 | 2 | 2020 |
| Seoul National University | Academic/Hospital | 2 | 0 | 1 | 2014 |
| Dongguk University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Eurofarma Laboratorios S.A. | For profit | 1 | 1 | 1 | 2017 |
| Hallym University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Kangbuk Samsung Hospital | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Kyung Hee University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Sungkyunkwan University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| University of Ulsan | Academic/Hospital | 1 | 1 | 1 | 2020 |
12 organizations
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