clodronate
Small moleculeexperimental
Clodronic acid (INN) or clodronate disodium (Na2CH2Cl2O6P2) (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its anti-inflammatory effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-α. — Wikipedia
Clinical trial activity
10 trials · 21 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
7
Phase 3
7
Phase 4
0
Earliest trial started Jul 1, 1996 (NCT00877097)
Timeline
Indications
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
Loading structure…
SMILES
O=P(O)(O)C(Cl)(Cl)P(=O)(O)O- Mol. weight
- 244.89 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL12318 ↗
- WikipediaClodronic acid ↗
- ChEMBLCHEMBL1520188 ↗
Also known as
- 177501
- acide clodronique
- acide clodronique
- acido clodronico
- acido clodronico
- acidum clodronicum
- acidum clodronicum
- bonefos
- bonefos
- clodronate
- clodronate
- clodronate
- clodronate
- clodronate disodium
- clodronate disodium
- clodronate disodium
- clodronic acid
- clodronic acid
- clodronic acid
- clodronic acid
- clodronic acid
- clodronic acid
- clodronic acid
- clodronic acid
- clodronsaeure
- clodronsaeure
- clodronsäure
- clodronsäure
- dichloromethanediphosphonic acid
- dichloromethanediphosphonic acid
- dichloromethylene-1,1-bisphosphonic acid
- dichloromethylene-1,1-bisphosphonic acid
- dichloromethylene-1,1-diphosphonic acid
- dichloromethylene-1,1-diphosphonic acid
- (dichloromethylene)bisphosphonic acid
- (dichloromethylene)bisphosphonic acid
- (dichloromethylene)diphosphonic acid
- (dichloromethylene)diphosphonic acid
- dichloromethylenediphosphonic acid
- dichloromethylidene diphosphonate
- dichloromethylidene diphosphonate
- (dichloro-phosphono-methyl)-phosphonic acid
- (dichloro-phosphono-methyl)-phosphonic acid
- disodium clodronate
- disodium clodronate
- methanedichlorodiphosphonic acid
- zk-00091106
- zk-00091106
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06055257 | Phase 3 | Dec 15, 2023 | University of Toronto |
| NCT06263517 | Phase 2/Phase 3 (Phase 3) | Oct 12, 2023 | SPA Società Prodotti Antibiotici S.p.A. |
| NCT01348243 | Phase 3 | Oct 1, 2011 | Chiesi |
| NCT01291433 | Phase 3 | Mar 1, 2011 | University of Paris |
| NCT00658268 | Phase 2 | Mar 1, 2008 | Lund University, Region Skane |
| NCT00127205 | Phase 3 | Jul 1, 2005 | Canadian Cancer Trials Group, Cancer and Leukemia Group B (CALGB), Eastern Cooperative Oncology Group, Mayo Clinic, National Cancer Institute (NCI), North Central Cancer Treatment Group, NSABP Foundation, Southwest Oncology Group, University of Alabama, Birmingham, University of Arizona, University of Calgary, University of North Carolina at Chapel Hill, University of Toronto, University of Washington |
| NCT03803839 | Early Phase 1 (Phase 1) | Mar 26, 2004 | University of Oulu |
| NCT00009945 | Phase 3 | Jan 1, 2001 | National Cancer Institute (NCI), North Central Cancer Treatment Group, NSABP Foundation, Southwest Oncology Group |
| NCT00003232 | Phase 3 | Nov 1, 1997 | Canadian Cancer Trials Group, University of Calgary |
| NCT00877097 | N/A | Jul 1, 1996 | Kuopio University Hospital |
Showing 10 of 10 trials
Page 1 / 1
Organizations
Research & Development (21)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Canadian Cancer Trials Group | Academic/Hospital | 2 | 1 | 1 | 1997 |
| National Cancer Institute (NCI) | Government | 2 | 0 | 1 | 2001 |
| North Central Cancer Treatment Group | Academic/Hospital | 2 | 0 | 1 | 2001 |
| NSABP Foundation | Academic/Hospital | 2 | 1 | 1 | 2001 |
| Southwest Oncology Group | Academic/Hospital | 2 | 1 | 1 | 2001 |
| University of Calgary | Academic/Hospital | 2 | 0 | 1 | 1997 |
| University of Toronto | Academic/Hospital | 2 | 1 | 1 | 2005 |
| Cancer and Leukemia Group B (CALGB) | Academic/Hospital | 1 | 0 | 1 | 2005 |
| Chiesi | For profit | 1 | 1 | 1 | 2011 |
| Eastern Cooperative Oncology Group | Academic/Hospital | 1 | 0 | 1 | 2005 |
| Kuopio University Hospital | Academic/Hospital | 1 | 1 | 1 | 1996 |
| Lund University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2005 |
| Region Skane | Government | 1 | 1 | 1 | 2008 |
| SPA Società Prodotti Antibiotici S.p.A. | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Alabama, Birmingham | Academic/Hospital | 1 | 0 | 1 | 2005 |
| University of Arizona | Academic/Hospital | 1 | 0 | 1 | 2005 |
| University of North Carolina at Chapel Hill | Academic/Hospital | 1 | 0 | 1 | 2005 |
| University of Oulu | Academic/Hospital | 1 | 1 | 1 | 2004 |
| University of Paris | Academic/Hospital | 1 | 1 | 1 | 2011 |
21 organizations
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