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fluorothymidine

Small moleculeexperimentalImaging agent

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Clinical trial activity

74 trials · 57 clinical orgs · 0 marketing orgs

Phase 1
31
Phase 2
25
Phase 3
2
Phase 4
1

Earliest trial started Nov 2, 1999 (NCT00002254)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2004

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetRadiopharmaceutical

    radiopharmaceutical

Chemistry & pharmacology

Loading structure…

SMILES

Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O
Mol. weight
244.22 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Imaging
18-fluoride

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 1-(3'-fluoro-3'-deoxy-beta-d-erythropentofuranosyl)thymine
  • (18f)3'-deoxy-3'-fluorothymidine
  • (18f)flt
  • 18f flt
  • 18f flt
  • 18f-flt
  • 18f-flt
  • 18f-flt
  • 18f-flt-tep
  • 18f fluorothymidine
  • 18f fluorothymidine
  • 18f-fluorothymidine
  • 18f-fluorothymidine
  • (18)flt cpd
  • 3'-deoxy-3'-(18f)fluorothymidine
  • 3'-deoxy-3'-18f-fluorothymidine
  • 3'-deoxy-3'-18f-fluorothymidine
  • [3'-deoxy-3'-[f-18] fluorothymidine
  • 3'-deoxy-3'-fluorothymidine
  • 3'-(f-18)fluoro-3'-deoxythymidine
  • 3'-fluoro-2',3'-dideoxythymidine
  • 3'-fluoro-3'-deoxythymidine
  • 3'-fluorothymidine
  • alovudine
  • alovudine
  • alovudine
  • alovudine
  • cl-184824
  • cl-184824
  • fddt
  • fluoro-l-thymidine
  • fluorothymidine
  • fluorothymidine
  • pet

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06498648Phase 1/Phase 2 (Phase 2)Jan 19, 2025National Cancer Institute (NCI), University of Texas at Houston
NCT04309552Phase 1Feb 1, 2021Cornell University, William Rhodes Center for Glioblastoma
NCT04271436Phase 2Apr 30, 2020Washington University in St. Louis
NCT04221438Phase 2Feb 2, 2020ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
NCT04067115Phase 1Oct 31, 2019Janssen Pharmaceutica NV, National Cancer Institute (NCI), National Institutes of Health (NIH), Sarcoma Alliance for Research through Collaboration, University of Pennsylvania
NCT03905538Early Phase 1 (Phase 1)Jul 31, 2019The University of Texas, Dallas
NCT03613259Early Phase 1 (Phase 1)Aug 31, 2018National Cancer Institute (NCI), OHSU Knight Cancer Institute
NCT03422731Early Phase 1 (Phase 1)Feb 15, 2018City of Hope National Medical Center, National Cancer Institute (NCI)
NCT03318497Phase 2Dec 11, 2017The University of Texas, Dallas
NCT03546556Early Phase 1 (Phase 1)Jan 1, 2017University of North Carolina at Chapel Hill
NCT02891616Phase 1Oct 10, 2016Washington University in St. Louis
NCT02774473N/AFeb 1, 2016University of Pennsylvania
NCT02392429Phase 2Dec 8, 2015ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
NCT02608216Phase 1Nov 1, 2015University of Pennsylvania
NCT02273271N/AOct 31, 2015European Organisation for Research and Treatment of Cancer
NCT02241668N/AJun 1, 2015General Electric, University of Texas at Houston
NCT02211768Phase 1Dec 8, 2014National Cancer Institute (NCI)
NCT02146222Phase 1Sep 1, 2014National Cancer Institute (NCI), Tyrogenex, University of Wisconsin
NCT02139150N/AMay 1, 2014Cornell University
NCT02108457Early Phase 1 (Phase 1)Feb 1, 2014University of Pennsylvania
Showing 20 of 74 trials
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Organizations

Research & Development (57)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Cancer Institute (NCI)Government301232003
Harvard UniversityAcademic/Hospital6432003
Cornell UniversityAcademic/Hospital5432003
University of PennsylvaniaAcademic/Hospital5422009
University of Texas at HoustonAcademic/Hospital4332009
LederleFor profit3311999
Mayo ClinicAcademic/Hospital3322007
National Institutes of Health (NIH)Government3022008
University of IowaAcademic/Hospital3312008
University of WashingtonAcademic/Hospital3312006
University of WisconsinAcademic/Hospital3112007
Columbia UniversityAcademic/Hospital2112009
ECOG-ACRIN Cancer Research GroupAcademic/Hospital2112015
National Taiwan UniversityAcademic/Hospital2222010
SiemensFor profit2222007
The University of Texas, DallasAcademic/Hospital2222017
University of AlbertaAcademic/Hospital2022007
University of BordeauxAcademic/Hospital2112008
University of CalgaryAcademic/Hospital2222007
Vanderbilt UniversityAcademic/Hospital2222010
57 organizations
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