human choriogonadotropin alfa
Trade name: hCG
Biologicalapproved
Approved
Jun 1, 1931
Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo, which eventually forms the placenta after implantation. The presence of hCG is detected in some pregnancy tests. Some cancerous tumors produce this hormone; therefore, elevated levels measured when the patient is not pregnant may lead to a cancer diagnosis and, if high enough, paraneoplastic syndromes, however, it is unknown whether this production is a contributing cause or an effect of carcinogenesis. The pituitary analog of hCG, known as luteinizing hormone (LH), is produced in the pituitary gland of males and females of all ages. — Wikipedia
Clinical trial activity
260 trials · 175 clinical orgs · 7 marketing orgs
Phase 1
23
Phase 2
91
Phase 3
58
Phase 4
78
Earliest trial started Dec 1, 1999 (NCT01735422)
Timeline
1930s
- Jun 1, 1931
Earliest FDA Approval
1970s
- Mar 5, 1973
Ferring — First NDA Organization
- Mar 5, 1973
Ferring — NDA Organization
- Mar 5, 1973
Fresenius — NDA Secondary Org
- Mar 26, 1974
Belmar Pharmacy — NDA Secondary Org
- Jan 16, 1976
Bristol-Myers Squibb — NDA Secondary Org
- Oct 20, 1976
Organon — NDA Secondary Org
1990s
- Jan 1, 1999
Earliest Phase 2 Sponsor(trial)
2000s
- Sep 20, 2000
Merck Serono — NDA Secondary Org
- Jan 1, 2003
Earliest Phase 3 Sponsor(trial)
- Jan 1, 2005
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Abortion, Spontaneous · Phase 4
- Anovulation · Phase 3
- Anti-Mullerian Hormone · Phase 2/Phase 3
- Azoospermia · Phase 2
- Brain Injuries, Traumatic · Phase 2
- BRCA1 Protein · Phase 4
- Breast Neoplasms · Phase 3
- Chorionic Gonadotropin · Phase 4
- Colorectal Neoplasms · Phase 3
- Deficiency Diseases · Phase 2
- Drug Evaluation · Phase 2/Phase 3
- Drugs, Investigational · Phase 4
- Embryo Implantation · Phase 4
- Embryonic Development · Phase 3
- Embryo Transfer · Phase 4
- Endocrine System Diseases · Phase 1/Phase 2
- Endometrium · Phase 4
- Esophageal Neoplasms · Phase 3
- Fertility · Phase 4
- Fertility Agents, Female · Phase 2
- Fertilization in Vitro · Phase 4
- Gonadal Disorders · Phase 1/Phase 2
- Gonadotropins · Phase 4
- Graft vs Host Disease · Phase 2
- Hamartoma · Phase 3
- Healthy Volunteers · Phase 1/Phase 2
- Hodgkin Disease · Phase 2
- Hormones · Phase 3
- Hypogonadism · Phase 4
- Infertility · Phase 4
- Infertility, Female · Phase 4
- Infertility, Male · Phase 1
- Kallmann Syndrome · Phase 4
- Klinefelter Syndrome · Phase 3
- Letrozole · Phase 4
- Liver Neoplasms · Phase 1/Phase 2
- Luteal Phase · Early Phase 1
- Mutation · Phase 4
- Myofascial Release Therapy · Early Phase 1
- Neoplasm Metastasis · Phase 1/Phase 2
- Neoplasms · Phase 1
- Osteoarthritis, Knee · Phase 1
- Ovarian Diseases · Phase 4
- Ovarian Follicle · Phase 4
- Ovarian Hyperstimulation Syndrome · Phase 4
- Ovarian Neoplasms · Phase 4
- Ovarian Reserve · Phase 4
- Ovulation · Phase 3
- Ovulation Induction · Phase 4
- Ovum · Phase 4
- Pituitary Diseases · Phase 3
- Polycystic Ovary Syndrome · Phase 4
- Pregnancy · Phase 4
- Pregnancy Complications · Phase 4
- Pregnancy Outcome · Phase 4
- Pregnancy Rate · Phase 2/Phase 3
- Progesterone · Phase 4
- Prostatic Neoplasms · Phase 2
- Prostatic Neoplasms, Castration-Resistant · Phase 1
- Reproduction · Phase 4
- Reproductive Health · Phase 4
- Reproductive Techniques, Assisted · Phase 3
- Spermatozoa · Phase 3
- Sperm Injections, Intracytoplasmic · Phase 4
- Stomach Neoplasms · Phase 2
- Stroke · Phase 2
- Tendon Injuries · Phase 4
- Uterine Diseases · Phase 4
- Vascular Endothelial Growth Factor A · Phase 3
Mechanism of action
LHCGR agonist
- Glycoprotein hormones alpha chainSupplementation
CGA supplementation
Approval history
- approvedJun 1, 1931
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- WikipediaHuman chorionic gonadotropin ↗
- ChEMBLCHEMBL1201509 ↗
- ChEMBLCHEMBL1201464 ↗
- NCATS6413W06WR3 ↗
- NCATS20ED16GHEB ↗
Also known as
- a.p.l.
- atc code g03 ga gonadotropins
- choragon
- choriogonadotropin alfa
- choriogonadotropin alfa
- choriogonadotropin alfa
- choriogonadotropin alfa
- choriogonadotropin alfa
- choriogonadotropin alfa
- choriogonadotropin alfa
- choriogonadotropin alpha
- choriomon
- chorionic gonadotrophin
- chorionic gonadotrophin
- chorionic gonadotrophin
- chorionic gonadotrophin alfa
- chorionic gonadotropin
- chorionic gonadotropin
- chorionic gonadotropin
- chorionic gonadotropin
- chorionic gonadotropin (human)
- chorionic gonadotropin (recombinant)
- da-3803
- equine chorionic gonadotropin
- fittydent
- follutein
- gonadotopin
- gonadotraphon lh
- gonadotropin
- gonadotropin
- gonadotropin,chorionic
- gonadotropin, chorionic
- gonadotropin, chorionic
- gonadotropin, chorionic
- gonadotropin, chorionic
- gonadotropins
- gonadtropin
- hcg
- hcg
- hcg
- h-hcg
- human chorionic gonadatropin
- human chorionic gonadotrophin
- human chorionic gonadotropin
- human chorionic gonadotropin
- human chorionic gonadotropin
- human-chorionic gonadotropin
- human menopausal gonadotrophin
- human menopausal gonadotrophin
- human menopausal gonadotrophin
- human menopausal gonadotropin
- human menopausal gonadotropin (urine derived)
- menotrophin
- menotrophin
- menotropin
- menotropins
- menotropins (fsh;lh)
- novarel
- novirel
- ntx 265
- ovidrel
- ovidrel
- ovitrelle
- ovitrelle
- ovitrelle
- pregnyl
- pregnyl
- profasi
- profast
- profast
- progestyl
- recombinant hcg
- recombinant human choriogonadotropin alfa
- urinary hcg
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07028710 | N/A | Jan 15, 2026 | University of Montpellier |
| NCT07108621 | Phase 3 | Sep 30, 2025 | University of Copenhagen, University of Southern Denmark |
| NCT07004192 | Phase 4 | Jun 2, 2025 | Fertility Center of Las Vegas |
| NCT06754332 | Phase 1 | Apr 1, 2025 | Zhejiang University |
| NCT06904599 | Phase 2 | Feb 1, 2025 | Universidad Autonoma de Nuevo Leon |
| NCT06531499 | Phase 1 | Oct 30, 2024 | Novartis |
| NCT06379217 | Phase 1 | Jul 29, 2024 | Novartis |
| NCT06511791 | Phase 1 | Jul 15, 2024 | Ferring |
| NCT06466486 | Phase 1 | Jun 14, 2024 | Ferring |
| NCT06179303 | Phase 2 | Jun 1, 2024 | Breast Cancer Research Foundation, University of Washington |
| NCT06481696 | N/A | Jun 1, 2024 | Andros Day Surgery Clinic |
| NCT06369610 | Phase 2 | Apr 22, 2024 | Mayo Clinic |
| NCT06150703 | Phase 3 | Feb 29, 2024 | Assistance Publique - Hôpitaux de Paris |
| NCT06146413 | Phase 2 | Dec 30, 2023 | Bedaya Hospital, Cairo University |
| NCT06142708 | N/A | Nov 1, 2023 | ART Fertility Clinics LLC, Embryolab Fertility Clinic |
| NCT06091436 | Phase 3 | Mar 24, 2023 | GeneScience Pharmaceuticals Co., Ltd., Sun Yat-Sen University |
| NCT05828966 | N/A | Feb 15, 2023 | Shaheed Zulfiqar Ali Bhutto Medical University |
| NCT05586802 | Phase 3 | Jan 1, 2023 | University of Lausanne |
| NCT06725004 | Phase 3 | Jan 1, 2023 | Bangladesh Medical University |
| NCT06413771 | N/A | Jan 1, 2023 | Uludag University |
Showing 20 of 260 trials
Page 1 / 13
Organizations
Research & Development (175)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 20 | 17 | 5 | 2013 |
| Merck | For profit | 15 | 8 | 4 | 2001 |
| Merck KGaA | For profit | 13 | 13 | 3 | 1999 |
| Merck Serono | For profit | 12 | 2 | 3 | 1999 |
| Free University of Brussels | Academic/Hospital | 11 | 11 | 4 | 2005 |
| Mansoura University | Academic/Hospital | 10 | 10 | 2 | 2007 |
| Tel Aviv University | Academic/Hospital | 8 | 8 | 3 | 2013 |
| Ferring | For profit | 7 | 6 | 4 | 2010 |
| Royan Institute | Academic/Hospital | 7 | 7 | 3 | 2009 |
| University of Copenhagen | Academic/Hospital | 6 | 6 | 3 | 2009 |
| Central South University | Academic/Hospital | 5 | 4 | 2 | 2016 |
| The Egyptian IVF-ET Center | Academic/Hospital | 5 | 3 | 2 | 2010 |
| University of California, San Diego | Academic/Hospital | 5 | 4 | 2 | 2007 |
| Damascus University | Academic/Hospital | 4 | 4 | 1 | 2019 |
| Hebrew University | Academic/Hospital | 4 | 4 | 2 | 2006 |
| Hospitalsenhed Midt | Academic/Hospital | 4 | 3 | 1 | 2009 |
| Stem Cell Therapeutics Corp. | For profit | 4 | 3 | 1 | 2006 |
| Sun Yat-Sen University | Academic/Hospital | 4 | 1 | 2 | 2012 |
| University of Athens | Academic/Hospital | 4 | 4 | 1 | 2014 |
| University of California, Irvine | Academic/Hospital | 4 | 1 | 1 | 2006 |
175 organizations
Page 1 / 9
Marketing (7)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Athenex, Inc. | For profit | MKTG | — |
| Belmar Pharmacy | For profit | NDA2 | Mar 26, 1974 |
| Bristol-Myers Squibb | For profit | NDA2 | Jan 16, 1976 |
| Ferring | For profit | NDA | Mar 5, 1973 |
| Fresenius | For profit | NDA2 | Mar 5, 1973 |
| Merck Serono | For profit | NDA2 | Sep 20, 2000 |
| Organon | For profit | NDA2 | Oct 20, 1976 |