fapi-46
Small moleculeexperimentalImaging agent
Clinical trial activity
20 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
9
Phase 3
0
Phase 4
0
Earliest trial started Aug 27, 2020 (NCT04459273)
Timeline
Indications
Studied for
- Adenomatous Polyposis Coli · Phase 2
- Adrenal Gland Neoplasms · Phase 1
- Alveolitis, Extrinsic Allergic · Early Phase 1
- Bile Duct Neoplasms · Phase 1
- Brain Neoplasms · Phase 1
- Carcinoma, Hepatocellular · Phase 1
- Carcinoma, Intraductal, Noninfiltrating · Phase 2
- Carcinoma, Ovarian Epithelial · Phase 1
- Carcinoma, Transitional Cell · Phase 1
- Cholangiocarcinoma · Phase 1
- Esophageal Neoplasms · Phase 2
- Fibroblasts · Phase 2
- Idiopathic Interstitial Pneumonias · Early Phase 1
- Lung Diseases · Phase 2
- Lung Diseases, Interstitial · Early Phase 1
- Lymphoma · Phase 1
- Melanoma · Phase 2
- Mesothelioma · Phase 2
- Neoplasm Metastasis · Phase 1
- Neoplasms · Phase 2
- Ovarian Neoplasms · Phase 2
- Pancreatic Neoplasms · Phase 2
- Pleural Diseases · Phase 2
- Pneumoconiosis · Early Phase 1
- Pneumonia · Early Phase 1
- Prostatic Neoplasms · Phase 1
- Pulmonary Fibrosis · Early Phase 1
- Radiation Pneumonitis · Early Phase 1
- Sarcoma · Early Phase 1
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Stomach Neoplasms · Phase 2
- Testicular Neoplasms · Phase 1
- Thymoma · Phase 1
- Thyroid Neoplasms · Phase 1
- Urinary Bladder Neoplasms · Phase 1
- Uterine Cervical Neoplasms · Phase 1
Mechanism of action
- Fibroblast activation protein alphaRadiopharmaceutical
FAP radiopharmaceutical
Chemistry & pharmacology
- Imaging
- 90-yttrium
Oral
No
Parenteral
No
Topical
No
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07273188 | Early Phase 1 (Phase 1) | Jan 1, 2026 | Mayo Clinic, The Leona M. and Harry B. Helmsley Charitable Trust |
| NCT06922825 | Early Phase 1 (Phase 1) | Nov 30, 2025 | Vanderbilt University |
| NCT06940427 | Phase 2 | Nov 19, 2025 | University of Wisconsin |
| NCT06957782 | N/A | Sep 30, 2025 | Erasmus University Rotterdam |
| NCT07215182 | Phase 2 | Aug 15, 2025 | University of Copenhagen |
| NCT06794372 | Phase 2 | May 31, 2025 | University of Lausanne |
| NCT06769828 | N/A | Feb 1, 2025 | Sun Yat-Sen University |
| NCT06790082 | Phase 2 | Jan 29, 2025 | Aalborg University |
| NCT06540872 | Phase 2 | Sep 10, 2024 | University of Munster |
| NCT05903807 | Phase 2 | Nov 17, 2023 | Aalborg University |
| NCT05898854 | Phase 2 | Sep 1, 2023 | Aalborg University |
| NCT05687747 | Phase 1 | Jan 31, 2023 | National University of Singapore |
| NCT05518903 | Phase 2 | Dec 1, 2022 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT05262855 | Phase 2 | May 2, 2022 | Sofie |
| NCT05263700 | N/A | Feb 23, 2022 | Peter MacCallum Cancer Centre |
| NCT05365802 | Early Phase 1 (Phase 1) | Nov 16, 2021 | University of California, Los Angeles |
| NCT05172310 | Phase 1 | Jun 2, 2021 | Karolinska Institute |
| NCT04457232 | Phase 1 | Sep 9, 2020 | University of California, Los Angeles |
| NCT04457258 | Early Phase 1 (Phase 1) | Sep 8, 2020 | National Cancer Institute (NCI), University of California, Los Angeles |
| NCT04459273 | Phase 1 | Aug 27, 2020 | University of California, Los Angeles |
Showing 20 of 20 trials
Page 1 / 1
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of California, Los Angeles | Academic/Hospital | 4 | 4 | 1 | 2020 |
| Aalborg University | Academic/Hospital | 3 | 3 | 1 | 2023 |
| Mayo Clinic | Academic/Hospital | 2 | 2 | 2 | 2022 |
| National Cancer Institute (NCI) | Government | 2 | 0 | 2 | 2020 |
| Erasmus University Rotterdam | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Karolinska Institute | Academic/Hospital | 1 | 1 | 1 | 2021 |
| National University of Singapore | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Peter MacCallum Cancer Centre | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Sofie | For profit | 1 | 1 | 1 | 2022 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| The Leona M. and Harry B. Helmsley Charitable Trust | Academic/Hospital | 1 | 0 | 1 | 2026 |
| University of Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Lausanne | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Munster | Academic/Hospital | 1 | 1 | 1 | 2024 |
| University of Wisconsin | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Vanderbilt University | Academic/Hospital | 1 | 1 | 1 | 2025 |
16 organizations
Page 1 / 1