CDEK
← Mechanisms of action

FAP

SINGLE PROTEINHomo sapiens
Preferred name: Fibroblast activation protein alpha ChEMBL ↗

Linked proteins

Drugs acting on this target (42)

Active Pharmaceutical Ingredient Mechanism Type ▲ Approval Status API Type Mechanism of Action
pti-122AntagonistexperimentalSmall moleculeFAP antagonist
[177lu]-fap-75Binding agentexperimentalSmall moleculeFAP binding agent
177lu-jh04Binding agentexperimentalSmall moleculeFAP binding agent
177lu-nrt6020Binding agentexperimentalPeptideFAP binding agent
68ga-jh04Binding agentexperimentalSmall moleculeFAP binding agent
bibh 1Binding agentexperimentalmAbFAP binding agent
ro7122290Binding agentexperimentalmAbFAP binding agent
sibrotuzumabBinding agentexperimentalmAbFAP binding agent
autologus fap-targeted immunosuppressive car-dcsImmunity, activeexperimentalCell therapyFAP immunity, active
fap mrna vaccineImmunity, activeexperimentalVaccineFAP immunity, active
re-directed fap-specific t cellsImmunity, passiveexperimentalCell therapyFAP immunity, passive
[177lu]lu-xt117InhibitorexperimentalSmall moleculeFAP inhibitor
64cu-lnth-1363sInhibitorexperimentalSmall moleculeFAP inhibitor
68ga-sfb6-zn01InhibitorexperimentalSmall moleculeFAP inhibitor
ava6103InhibitorexperimentalPeptideFAP inhibitor
fap-2286InhibitorexperimentalmAbFAP inhibitor
hrs-6768InhibitorexperimentalSmall moleculeFAP inhibitor
monoclonal antibody f19InhibitorexperimentalmAbFAP inhibitor
omtx705InhibitorexperimentalmAbFAP inhibitor
pnt6555InhibitorexperimentalSmall moleculeFAP inhibitor
ro6874813InhibitorexperimentalmAbFAP inhibitor
sibrotuzumabInhibitorexperimentalmAbFAP inhibitor
[177lu]lu-oncofap-23RadiodepletionexperimentalSmall moleculeFAP radiodepletion
[203pb]pb-psv359RadiodepletionexperimentalSmall moleculeFAP radiodepletion
[225ac]ac-a9-3408RadiodepletionexperimentalRecombinant proteinFAP radiodepletion
[ac 225]rtx-2358RadiodepletionexperimentalSmall moleculeFAP radiodepletion
131i-sibrotuzumabRadiodepletionexperimentalmAbFAP radiodepletion
225ac-fapi-xtRadiodepletionexperimentalPeptideFAP radiodepletion
ly4337713RadiodepletionexperimentalSmall moleculeFAP radiodepletion
[177lu]lu-tefapi-06RadiopharmaceuticalexperimentalPeptideFAP radiopharmaceutical
[68ga]ga-nns309RadiopharmaceuticalexperimentalSmall moleculeFAP radiopharmaceutical
[99mtc]tc-hynic-fapiRadiopharmaceuticalexperimentalSmall moleculeFAP radiopharmaceutical
177lu-ctr-fapiRadiopharmaceuticalexperimentalPeptideFAP radiopharmaceutical
177lu-im-3050RadiopharmaceuticalexperimentalmAbFAP radiopharmaceutical
18f-fapibiotinRadiopharmaceuticalexperimentalPeptideFAP radiopharmaceutical
68ga-fapi-biotinRadiopharmaceuticalexperimentalPeptideFAP radiopharmaceutical
68ga-gp-01RadiopharmaceuticalexperimentalPeptideFAP radiopharmaceutical
68ga-lnc1007RadiopharmaceuticalexperimentalPeptideFAP radiopharmaceutical
68ga-psfaRadiopharmaceuticalexperimentalmAbFAP radiopharmaceutical
fapi-46RadiopharmaceuticalexperimentalSmall moleculeFAP radiopharmaceutical
fpyqcpRadiopharmaceuticalexperimentalSmall moleculeFAP radiopharmaceutical
technetium [99mtc]-h7ndRadiopharmaceuticalexperimentalSmall moleculeFAP radiopharmaceutical