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mecobalamin

Small moleculeexperimental

Methylcobalamin (mecobalamin, MeCbl, or MeB12) is a cobalamin, a form of vitamin B12. It differs from cyanocobalamin in that the cyano group at the cobalt is replaced with a methyl group. Methylcobalamin features an octahedral cobalt(III) centre and can be obtained as bright red crystals. From the perspective of coordination chemistry, methylcobalamin is notable as a rare example of a compound that contains metal–alkyl bonds. Nickel–methyl intermediates have been proposed for the final step of methanogenesis. — Wikipedia

Clinical trial activity

24 trials · 24 clinical orgs · 0 marketing orgs

Phase 1
4
Phase 2
7
Phase 3
6
Phase 4
5

Earliest trial started Mar 1, 2003 (NCT00165711)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 1, 2022

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Mol. weight
1344.4 g/mol
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • asimil b-12
  • b-max
  • ch3-b12
  • cobinamide, co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-d-ribofuranosyl-1h-benzimidazole
  • co-methylcobalamin
  • mecbl
  • mecbl
  • mecobalamin
  • mecobalamin
  • mecobalamin
  • mecobalamin
  • mecobalamin
  • mecobalamin
  • mecobalamin
  • mecobalamin, (13beta)-isomer
  • mecobalamin, 3h-labeled
  • mecobalamin, 57co-labeled
  • mecobalamin, co-methyl-13c-labeled
  • mecobalamin, co-methyl-14c-labeled
  • mecobalamin monohydrate
  • methycobal
  • methylcobalamin
  • methylcobalamin
  • methylcobalamin
  • methylcobalamin
  • methylcobalamin
  • methylcobalamine
  • methyl cobalamine
  • methylcobaz
  • methyl(iii)cobalamin
  • methyl(iii)cobalamin
  • methyl vitamin b12
  • methylvitamin b12

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06813274Phase 2Jan 1, 2026Chengdu University of Traditional Chinese Medicines
NCT07274696Phase 3Dec 1, 2025Sanya People's Hospital, Sichuan University
NCT07281872Phase 1Oct 29, 2025WanBangDe Pharmaceutical Group Co.,Ltd.
NCT07158099Phase 1Sep 15, 2025WanBangDe Pharmaceutical Group Co.,Ltd.
NCT07133438Phase 4Sep 1, 2025Chongqing Medical University
NCT06220929Phase 4Jan 15, 2024Sichuan University
NCT05623384N/ANov 14, 2022Yangzhou University
NCT05184049Phase 4Jan 31, 2022Central South University
NCT05165069Phase 3Jan 1, 2022Sun Yat-Sen University
NCT04800666N/AMar 1, 2021Yangzhou University
NCT03968042Phase 2Jun 30, 2019Sun Yat-Sen University
NCT03983200N/AJun 15, 2019Nanjing Medical University
NCT05008042Phase 1/Phase 2 (Phase 2)Feb 6, 2019Karolinska Institute, Kronoberg County Council, Landstinget i Kalmar Län, Linnaeus University, Region Östergötland
NCT02923388Phase 2Oct 1, 2016Bangladesh Medical University
NCT02853942Early Phase 1 (Phase 1)Oct 1, 2016Jiao Tong University
NCT03167918Phase 2/Phase 3 (Phase 3)Jul 21, 2014Liaoning Hospital of Traditional Chinese Medicine
NCT02540642N/AOct 1, 2010SMT KASHIBAI NAVALE MEDICAL COLLEGE
NCT01192113Phase 4Apr 1, 2010Eisai, People's Liberation Army of China
NCT00699478Phase 2Apr 1, 2008Yonsei University
NCT00445172Phase 2/Phase 3 (Phase 3)Feb 1, 2008Eisai
Showing 20 of 24 trials
Page 1 / 2

Organizations

Research & Development (24)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
EisaiFor profit4422003
Sichuan UniversityAcademic/Hospital2222024
Sun Yat-Sen UniversityAcademic/Hospital2222019
WanBangDe Pharmaceutical Group Co.,Ltd.For profit2212025
Yangzhou UniversityAcademic/Hospital2212021
Bangladesh Medical UniversityAcademic/Hospital1112016
Central South UniversityAcademic/Hospital1112022
Chengdu University of Traditional Chinese MedicinesAcademic/Hospital1112026
Chongqing Medical UniversityAcademic/Hospital1112025
Hoosier Cancer Research NetworkAcademic/Hospital1012006
Jiao Tong UniversityAcademic/Hospital1112016
Karolinska InstituteAcademic/Hospital1012019
Kronoberg County CouncilGovernment1012019
Landstinget i Kalmar LänAcademic/Hospital1012019
Liaoning Hospital of Traditional Chinese MedicineAcademic/Hospital1112014
Linnaeus UniversityAcademic/Hospital1112019
Nanjing Medical UniversityAcademic/Hospital1112019
People's Liberation Army of ChinaGovernment1012010
Region ÖstergötlandGovernment1012019
Sanya People's HospitalAcademic/Hospital1012025
24 organizations
Page 1 / 2