urapidil
Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist. Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe. — Wikipedia
Clinical trial activity
6 trials · 8 clinical orgs · 0 marketing orgs
Earliest trial started Oct 1, 2015 (NCT04500249)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
HTR1A agonist
- Alpha-1a adrenergic receptorANTAGONIST
ADRA1A antagonist
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaUrapidil ↗
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06677970 | Phase 3 | Dec 1, 2024 | Yonsei University |
| NCT03790800 | Phase 3 | May 1, 2019 | Huazhong University of Science and Technology, Sichuan University, University of New South Wales |
| NCT03529149 | Phase 4 | Apr 8, 2018 | Capital Medical University |
| NCT03300479 | Phase 4 | Jun 15, 2017 | University of Zurich |
| NCT03497351 | N/A | May 1, 2017 | People's Liberation Army of China |
| NCT04500249 | N/A | Oct 1, 2015 | Silesian University of Medicine |
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Capital Medical University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2019 |
| People's Liberation Army of China | Government | 1 | 1 | 1 | 2017 |
| Sichuan University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Silesian University of Medicine | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of New South Wales | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Zurich | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Yonsei University | Academic/Hospital | 1 | 1 | 1 | 2024 |