etrasimod

Trade name: Velsipity

Small moleculeapproved

Approved

Oct 12, 2023

Clinical trial activity

20 trials · 7 clinical orgs · 1 marketing orgs

Phase 1
3
Phase 2
13
Phase 3
7
Phase 4
0

Earliest trial started Jun 30, 2019 (NCT03945188)

Timeline

2010s

  1. Jan 1, 2019

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2019

    Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2023

    Pfizer — Earliest Phase 1 Sponsor(trial)

  2. Oct 12, 2023

    Pfizer — Earliest FDA Approval

  3. Oct 12, 2023

    Pfizer — Marketing Organization

  4. Oct 12, 2023

    Pfizer — NDA Organization

Indications

Mechanism of action

Approval history

  • approvedOct 12, 2023

Chemistry & pharmacology

Loading structure…

SMILES

O=C(O)C[C@H]1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21
Mol. weight
457.49 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral
Availability
Prescription Only

Oral

Yes

Parenteral

No

Topical

No

Sources

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07243639N/AOct 1, 2025Showa Inan General Hospital
NCT07153159Phase 1Aug 7, 2025Pfizer
NCT06521762Phase 2Aug 31, 2024Pfizer, Yale University
NCT06140290Phase 1Dec 11, 2023Pfizer
NCT05956002Phase 1Sep 4, 2023Pfizer
NCT05732454Phase 2/Phase 3 (Phase 3)Jan 18, 2023Pfizer
NCT05287126Phase 2Jan 15, 2023Arena Pharmaceuticals, Pfizer
NCT05061446Phase 2Oct 16, 2021Arena Pharmaceuticals
NCT05033340Phase 2/Phase 3 (Phase 3)Sep 1, 2021Arena Pharmaceuticals, Cairo University
NCT04682639Phase 2Dec 31, 2020Arena Pharmaceuticals
NCT04706793Phase 3Dec 25, 2020Arena Pharmaceuticals
NCT04607837Phase 2Nov 10, 2020Arena Pharmaceuticals
NCT04556734Phase 2Aug 31, 2020Arena Pharmaceuticals
NCT03996369Phase 3Jun 30, 2020Arena Pharmaceuticals
NCT04173273Phase 2Dec 31, 2019Arena Pharmaceuticals
NCT04162769Phase 2Oct 24, 2019Arena Pharmaceuticals
NCT03950232Phase 3Sep 30, 2019Arena Pharmaceuticals
NCT04176588Phase 3Sep 10, 2019Everstar Therapeutics Limited, People's Liberation Army of China
NCT03945188Phase 3Jun 30, 2019Arena Pharmaceuticals
NCT06025227N/APfizer
Showing 20 of 20 trials
Page 1 / 1

Organizations

Research & Development (7)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Arena PharmaceuticalsFor profit121222019
PfizerFor profit7542023
Cairo UniversityAcademic/Hospital1012021
Everstar Therapeutics LimitedFor profit1112019
People's Liberation Army of ChinaGovernment1012019
Showa Inan General HospitalAcademic/Hospital1112025
Yale UniversityAcademic/Hospital1112024
7 organizations
Page 1 / 1

Marketing (3)

OrganizationOrg typeRelationshipDate
PfizerFor profitSYNOct 12, 2023
PfizerFor profitMKTGOct 12, 2023
PfizerFor profitNDAOct 12, 2023