methylcellulose
Botanicalexperimental
Hypromellose (INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products. — Wikipedia
Clinical trial activity
42 trials · 59 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
10
Phase 3
6
Phase 4
14
Earliest trial started Jan 1, 2007 (NCT00485108)
Timeline
Indications
Approved for
Studied for
- Acanthamoeba Keratitis · Phase 2
- Cardiopulmonary Bypass · Phase 4
- Cataract · Phase 4
- Cesarean Section · Phase 2/Phase 3
- Conjunctivitis, Allergic · Phase 4
- Conjunctivitis, Viral · Phase 3
- Corneal Diseases · Phase 2
- Corneal Endothelial Cell Loss · Phase 2
- Dry Eye Syndromes · Phase 4
- Fuchs' Endothelial Dystrophy · Phase 2
- General Surgery · Phase 2/Phase 3
- Glaucoma · Phase 4
- Graves Ophthalmopathy · Phase 2
- Irritable Bowel Syndrome · Phase 4
- Keratitis · Phase 4
- Lacrimal Duct Obstruction · Phase 3
- Macular Degeneration · Phase 2/Phase 3
- Menopause · Phase 3
- Obesity · Phase 4
- Pain · Phase 1
- Periodontal Diseases · Phase 4
- Pharmacological and Toxicological Phenomena · Phase 1
- Prostatic Neoplasms · Phase 2
- Sjogren's Syndrome · Phase 3
- Thyroid Neoplasms · Phase 3
- Vaginal Diseases · Phase 3
- Vulvar Diseases · Phase 3
- Wet Macular Degeneration · Phase 2/Phase 3
- Xerostomia · Phase 3
Mechanism of action
- Unspecified targetOTHER
Bulk-forming laxative
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaHypromellose ↗
- NCATSZ944H5SN0H ↗
- ChEMBLCHEMBL2109198 ↗
- WikipediaMethyl cellulose ↗
- WikipediaCarboxymethyl cellulose ↗
- NCATS05JZI7B19X ↗
Also known as
- celevac
- cellucon
- cellulose methyl
- cellulose methylate
- cellulose methyl ether
- citrucel
- cologel
- cologel
- methocel a
- methocel a
- methycellulose
- methylated cellulose
- methylated cellulose
- methylcellulose
- methylcellulose
- methylcellulose
- methylcellulose
- methylcellulose
- methyl cellulose
- methylcellulosum
- methylcellulosum
- metilcelulosa
- metilcelulosa
- nilstim
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06962462 | N/A | May 5, 2025 | South Valley University |
| NCT07194447 | N/A | Oct 3, 2024 | University of Baghdad |
| NCT06514586 | Phase 3 | Sep 30, 2024 | Government of Saudi Arabia |
| NCT06551961 | N/A | Aug 9, 2024 | University of East Anglia, University of Nottingham |
| NCT06361108 | Phase 1 | May 16, 2024 | Hanmi Pharmaceutical |
| NCT06551948 | N/A | Jan 1, 2024 | University of East Anglia, University of Nottingham |
| NCT06291272 | N/A | Oct 15, 2023 | Quadram Institute, University of Nottingham |
| NCT05999630 | Phase 3 | Aug 21, 2023 | Vanderbilt University |
| NCT05911347 | N/A | May 9, 2023 | University of East Anglia, University of Nottingham |
| NCT05451667 | Phase 1 | Aug 15, 2022 | Government of China |
| NCT06221345 | Phase 4 | Dec 7, 2021 | Chang Gung University |
| NCT04871360 | N/A | May 5, 2021 | Universidad de Guanajuato |
| NCT05924893 | N/A | Jan 1, 2021 | Minia University |
| NCT04252209 | Phase 3 | Mar 31, 2020 | Cairo University |
| NCT03452891 | Phase 4 | Jul 1, 2018 | University of Nebraska |
| NCT03575130 | Phase 2 | Jun 5, 2018 | University of Erlangen-Nuremberg |
| NCT03484507 | Phase 2 | Jan 1, 2018 | University of California, San Francisco |
| NCT04951869 | Phase 2/Phase 3 (Phase 3) | Apr 26, 2017 | National University of Malaysia |
| NCT02845336 | Phase 2 | Mar 5, 2017 | Johns Hopkins University |
| NCT03380624 | Phase 4 | Mar 1, 2017 | Allergan, Ohio State University |
Showing 20 of 42 trials
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Organizations
Research & Development (59)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Nottingham | Academic/Hospital | 4 | 4 | 1 | 2023 |
| Harvard University | Academic/Hospital | 3 | 2 | 2 | 2008 |
| ORA, Inc. | For profit | 3 | 1 | 2 | 2008 |
| University of East Anglia | Academic/Hospital | 3 | 0 | 1 | 2023 |
| Allergan | For profit | 2 | 1 | 2 | 2007 |
| Ohio State University | Academic/Hospital | 2 | 1 | 2 | 2015 |
| University of Nebraska | Academic/Hospital | 2 | 2 | 2 | 2010 |
| Aga Khan University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Bascom Palmer Eye Institute | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Berhan Public Health and Eye Care Consultancy PLC | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Biotechnology Institute IMASD | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Cairo University | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Chang Gung University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Clinica Oftamologica Zona Sul | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Edward Holland, MD | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Georgetown University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Glaucoma Research Society of Canada | Academic/Hospital | 1 | 0 | 1 | 2007 |
| GlaxoSmithKline | For profit | 1 | 0 | 1 | 2014 |
| Government of China | Government | 1 | 1 | 1 | 2022 |
| Government of Saudi Arabia | Government | 1 | 1 | 1 | 2024 |
59 organizations
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