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estriol

Small moleculeexperimental

Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estrone. Levels of estriol in women who are not pregnant are almost undetectable. However, during pregnancy, estriol is synthesized in very high quantities by the placenta and is the most produced estrogen in the body by far, although circulating levels of estriol are similar to those of other estrogens due to a relatively high rate of metabolism and excretion. Relative to estradiol, both estriol and estrone have far weaker activity as estrogens. — Wikipedia

Clinical trial activity

24 trials · 52 clinical orgs · 0 marketing orgs

Phase 1
5
Phase 2
10
Phase 3
4
Phase 4
4

Earliest trial started Feb 1, 2006 (NCT00302731)

Timeline

2000s

  1. Jan 1, 2006

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

  3. Jan 1, 2009

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1C[C@@H](O)[C@@H]2O
Mol. weight
288.39 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Topical

Oral

No

Parenteral

No

Topical

Yes

Sources

Also known as

  • 1,3,5(10)-estratriene-3,16-alpha,17beta-triol
  • 1,3,5(10)-estratriene-3,16-alpha,17beta-triol
  • (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol
  • (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol
  • 16-alpha-hydroxyestradiol
  • 16-alpha-hydroxyestradiol
  • 16alpha-hydroxyestradiol
  • 16alpha-hydroxyestradiol
  • (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol
  • (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol
  • 16α-hydroxyestradiol
  • 16α-hydroxyestradiol
  • 3,16alpha,17beta-trihydroxy-delta(1,3,5)-estratriene
  • 3,16alpha,17beta-trihydroxy-delta(1,3,5)-estratriene
  • destriol
  • deuslon-a
  • deuslon-a
  • estratriol
  • estriel
  • estriel
  • estriol
  • estriol
  • estriol
  • estriol
  • estriol
  • estriol
  • estriol
  • estriol
  • estriol-16,17-dihemisuccinate
  • estriol acetate benzoate
  • estriol propionate
  • estriol propionate
  • estriol succinate
  • estriol succinate
  • estriol succinate
  • estriol succinate
  • estriol succinate
  • estriol succinate disodium
  • estriol succinate disodium salt
  • estriol succinate, disodium salt
  • estriol succinate sodium
  • gynest
  • gynest
  • oestriol
  • oestriol
  • oestriol
  • ortho-gynest
  • ortho-gynest
  • ovestin
  • ovestin
  • ovestrion
  • stiptanon
  • styptanon
  • succinylestriol
  • succinylestriol
  • succinylestriol
  • succinylestriol
  • synapause
  • theelol
  • theelol
  • trihydroxyestrin
  • trihydroxyestrin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06873971N/AMar 26, 2025University of Nove de Julho
NCT06425978Phase 4May 30, 2024Fundación Santiago Dexeus Font, Regen Lab SA
NCT06391372Phase 3Apr 30, 2024University of Ankara
NCT05335317N/AApr 18, 2022Government of Russia, Privolzhsky Research Medical University
NCT04735549N/AFeb 15, 2021Government of Russia
NCT04159493Phase 2Jan 5, 2020Aspen Pharmaceuticals
NCT03774407Phase 2/Phase 3 (Phase 3)Aug 10, 2019Texas Tech University
NCT04045379N/AAug 5, 2019Federal University of Sao Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo
NCT03343912Phase 1Nov 10, 2017Galeno Desenvolvimento de Pesquisas, SocraTec R&D GmbH
NCT03116022Phase 1Jun 1, 2017University of Sao Paulo
NCT03044652Phase 4Nov 1, 2016Bremer Pharmacovigilance Service GmbH, Dr. August Wolff GmbH & Co. KG Arzneimittel, GCP-Service International Ltd. & Co. KG, pontifical catholic university
NCT02906111Phase 4Nov 1, 2016Policlinico Universitario, Catania, University of Catania
NCT02967510Phase 2Oct 1, 2016ITF Research Pharma, S.L.U.
NCT03363997Phase 1Sep 23, 2016Galeno Desenvolvimento de Pesquisas, SocraTec R&D GmbH
NCT02733731Phase 1Feb 1, 2016Sun Yat-Sen University
NCT02413008Phase 2Apr 1, 2015ITF Research Pharma, S.L.U., Spanish Breast Cancer Research Group
NCT03032848Phase 4Nov 26, 2013Universidade Federal do Parana
NCT01466114Phase 2Oct 1, 2011University of California, Los Angeles
NCT01408030Phase 2Aug 1, 2011Augusta University, Hereditary Hemorrhagic Telangiectasia Foundation International
NCT00908570Phase 1Jun 1, 2009Gynuity Health Projects, Oregon Health and Science University, Tulane University, University of California, Los Angeles, University of Illinois at Chicago, University of Pittsburgh
Showing 20 of 24 trials
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Organizations

Research & Development (52)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of California, Los AngelesAcademic/Hospital3222007
Galeno Desenvolvimento de PesquisasAcademic/Hospital2212016
Government of RussiaGovernment2212021
ITF Research Pharma, S.L.U.For profit2212015
Mayo ClinicAcademic/Hospital2122007
SocraTec R&D GmbHFor profit2012016
University of KansasAcademic/Hospital2112006
Aspen PharmaceuticalsFor profit1112020
Augusta UniversityAcademic/Hospital1112011
Bremer Pharmacovigilance Service GmbHFor profit1012016
Dartmouth UniversityAcademic/Hospital1012007
Dr. August Wolff GmbH & Co. KG ArzneimittelFor profit1112016
Federal University of Sao PauloAcademic/Hospital1112019
Fundação de Amparo à Pesquisa do Estado de São PauloAcademic/Hospital1012019
Fundación Santiago Dexeus FontAcademic/Hospital1112024
GCP-Service International Ltd. & Co. KGFor profit1012016
Gynuity Health ProjectsAcademic/Hospital1112009
Hereditary Hemorrhagic Telangiectasia Foundation InternationalAcademic/Hospital1012011
Hospital Universitario Central de AsturiasAcademic/Hospital1012008
ItalfarmacoFor profit1112008
52 organizations
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