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berberine

Small moleculeexperimental

Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids, occurring naturally as a secondary metabolite in some plants including species of Berberis, from which its name is derived. — Wikipedia

Clinical trial activity

100 trials · 78 clinical orgs · 0 marketing orgs

Phase 1
10
Phase 2
26
Phase 3
20
Phase 4
27

Earliest trial started Sep 1, 1998 (NCT00004033)

Timeline

1990s

  1. Jan 1, 1998

    Earliest Phase 2 Sponsor(trial)

2000s

  1. Jan 1, 2004

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2005

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2
Mol. weight
336.37 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • alpha-lipoic acid
  • berberine
  • berberine
  • berberine
  • berberine
  • berberine
  • berberine chloride
  • berberine chloride
  • berberine chloride
  • berberine glucogold
  • berberine hydrochloride
  • berberine hydrochloride
  • gnf-pf-4545
  • gnf-pf-4545
  • htd1801
  • liposomal nddp
  • picrorhiza

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07129460Phase 4Oct 1, 2025People's Liberation Army of China
NCT06911983N/AJul 1, 2025Government of Russia, Solvay
NCT07306988Phase 4Apr 17, 2025Nanjing Medical University
NCT07180563Phase 1/Phase 2 (Phase 2)Mar 15, 2025Zhejiang University
NCT06514274Phase 4Oct 31, 2024People's Liberation Army of China
NCT06782646Phase 2/Phase 3 (Phase 3)Aug 1, 2024The University of Hong Kong
NCT06415773Phase 3May 31, 2024HighTide Biopharma Pty Ltd
NCT06732908N/AMay 27, 2024—
NCT06863922N/AMay 3, 2024Government of Russia, Solvay
NCT06603688Phase 4Nov 20, 2023People's Liberation Army of China
NCT06353347Phase 3Nov 13, 2023HighTide Biopharma Pty Ltd
NCT06350890Phase 3Nov 5, 2023HighTide Biopharma Pty Ltd
NCT06591767N/AOct 1, 2023Liaquat University of Medical & Health Sciences, University of Urbino "Carlo Bo"
NCT05845931N/AMay 5, 2023University of Greifswald
NCT06202157N/AApr 1, 2023Factors Group of Nutritional Companies Inc.
NCT05749874Phase 4Apr 1, 2023Chinese Academy of Medical Sciences
NCT05647915Phase 4Dec 15, 2022Chinese Academy of Medical Sciences
NCT05623189Phase 2Nov 30, 2022HighTide Biopharma Pty Ltd
NCT05480670N/ANov 15, 2022King Edward Medical University
NCT05570357Phase 2/Phase 3 (Phase 3)Nov 1, 2022National Nutrition and Food Technology Institute
Showing 20 of 100 trials
Page 1 / 5

Organizations

Research & Development (78)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
People's Liberation Army of ChinaGovernment141332014
HighTide Biopharma Pty LtdFor profit111132017
Jiao Tong UniversityAcademic/Hospital7442004
Tianjin Medical UniversityAcademic/Hospital5422014
Chinese Academy of Medical SciencesAcademic/Hospital4422018
University of PaviaAcademic/Hospital4422017
RottapharmFor profit3322009
The University of Hong KongAcademic/Hospital3312017
University of GuadalajaraAcademic/Hospital3332013
University of Naples Frederico IIAcademic/Hospital3222009
Capital Medical UniversityAcademic/Hospital2212019
Factors Group of Nutritional Companies Inc.For profit2212022
Fudan UniversityAcademic/Hospital2222008
Government of RussiaGovernment2012024
Heilongjiang University of Traditional Chinese MedicineAcademic/Hospital2212009
Nanjing Medical UniversityAcademic/Hospital2212016
National Cancer Institute (NCI)Government2121998
National Polytechnic Institute, MexicoAcademic/Hospital2212016
Peking UniversityAcademic/Hospital2222016
SolvayFor profit2212024
78 organizations
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