taurolidine
Trade name: Defencath
Small moleculeexperimental
Taurolidine is an antimicrobial that is used to prevent infections in catheters. Side effects and the induction of bacterial resistance is uncommon. It is also being studied as a treatment for cancer. — Wikipedia
Clinical trial activity
12 trials · 18 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
6
Phase 3
2
Phase 4
4
Earliest trial started Mar 1, 2001 (NCT00021034)
Timeline
Indications
Approved for
Studied for
- Brain Neoplasms · Phase 1
- Catheter-Related Infections · Phase 4
- Central Venous Catheters · Phase 4
- Fallopian Tube Neoplasms · Phase 1
- Hamartoma · Phase 1
- Hemodialysis, Home · Phase 4
- Infections · Phase 3
- Kidney Failure, Chronic · Phase 3
- Ovarian Neoplasms · Phase 1
- Parenteral Nutrition · Phase 3
- Parenteral Nutrition, Home · Phase 4
- Periodontitis · Phase 2
- Renal Dialysis · Phase 2
- Sepsis · Phase 3
- Thrombosis · Phase 4
- Vascular Access Devices · Phase 2
Mechanism of action
- Cell wallDISRUPTING AGENT
Cell wall disrupting agent
Interacts with bacterial cell wall and also disrupts adhesion to surfaces.
- Lipopolysaccharide (LPS)INHIBITOR
Lipopolysaccharide (LPS) inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1- Mol. weight
- 284.36 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
No
First in class
Sources
- WikipediaTaurolidine ↗
- ChEMBLCHEMBL2105420 ↗
Also known as
- 4,4'-methylenebis-(tetrahydro-1,2,4-thiadiazine- 1,1-dioxide)
- bis- (1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)methane
- bis(1,1-dioxo-perhydro-1,2,4-thiadiazinyl-4)methane
- hep500
- tauroflex
- tauroflex
- tauroflex
- tauroflex
- tauroflex
- taurolidine
- taurolidine
- taurolidine
- taurolidine
- taurolidine
- taurolidine
- taurolidine
- taurolin
- taurolin
- tauroline
- tauroline
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07310069 | Phase 2 | May 1, 2025 | Jiao Tong University |
| NCT07074821 | Phase 2 | Mar 1, 2023 | Government of Oman |
| NCT04093895 | Phase 2 | Aug 26, 2019 | Geistlich Pharma AG, PerioHealth Clinic Houston |
| NCT03539718 | Phase 4 | May 15, 2018 | Ain Shams University |
| NCT02651428 | Phase 3 | Dec 1, 2015 | CorMedix, Davita Clinical Research, Frenova Renal Research, JMI Laboratories, PPD, Spectra Clinical Research |
| NCT02313883 | Phase 1/Phase 2 (Phase 2) | Jul 1, 2015 | Geistlich Pharma AG, PerioHealth Clinic Houston, University of Michigan |
| NCT02515201 | Phase 4 | Sep 1, 2014 | Federal University of Rio Grande do Sul |
| NCT02868697 | Phase 4 | Nov 1, 2013 | Hamad Medical Corporation |
| NCT02009189 | Phase 4 | Nov 1, 2012 | Stanley Dudrick's Memorial Hospital |
| NCT00321165 | Phase 3 | Jun 1, 2006 | Radboud University |
| NCT00022360 | Phase 1 | May 1, 2001 | Cornell University, National Cancer Institute (NCI) |
| NCT00021034 | Phase 1 | Mar 1, 2001 | Cornell University, National Cancer Institute (NCI) |
Showing 12 of 12 trials
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Organizations
Research & Development (18)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cornell University | Academic/Hospital | 2 | 2 | 1 | 2001 |
| Geistlich Pharma AG | For profit | 2 | 2 | 1 | 2015 |
| National Cancer Institute (NCI) | Government | 2 | 0 | 1 | 2001 |
| PerioHealth Clinic Houston | Academic/Hospital | 2 | 0 | 1 | 2015 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| CorMedix | For profit | 1 | 1 | 1 | 2015 |
| Davita Clinical Research | For profit | 1 | 0 | 1 | 2015 |
| Federal University of Rio Grande do Sul | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Frenova Renal Research | For profit | 1 | 0 | 1 | 2015 |
| Government of Oman | Government | 1 | 1 | 1 | 2023 |
| Hamad Medical Corporation | For profit | 1 | 1 | 1 | 2013 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| JMI Laboratories | For profit | 1 | 0 | 1 | 2015 |
| PPD | For profit | 1 | 0 | 1 | 2015 |
| Radboud University | Academic/Hospital | 1 | 1 | 1 | 2006 |
| Spectra Clinical Research | For profit | 1 | 0 | 1 | 2015 |
| Stanley Dudrick's Memorial Hospital | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Michigan | Academic/Hospital | 1 | 0 | 1 | 2015 |
18 organizations
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