molibresib
Small moleculeexperimental
Clinical trial activity
9 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Mar 28, 2012 (NCT01587703)
Timeline
Indications
Mechanism of action
Bromodomain and extra-terminal motif (BET) inhibitor
- Bromodomain-containing protein 3INHIBITOR
BRD3 inhibitor
- Bromodomain-containing protein 1INHIBITOR
BRD1 inhibitor
- Bromodomain-containing protein 2INHIBITOR
BRD2 inhibitor
- Bromodomain testis-specific proteinINHIBITOR
BRDT inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21- Mol. weight
- 423.9 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297217 ↗
- ChEMBLCHEMBL1232461 ↗
Also known as
- gsk525762
- gsk525762
- gsk525762
- gsk 525762
- gsk525762a
- gsk 525762a
- gsk-525762a
- i-bet762
- i-bet compound
- ibet compound
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04116359 | Phase 1/Phase 2 (Phase 2) | Dec 6, 2019 | Harvard University, National Cancer Institute (NCI) |
| NCT03925428 | Phase 1 | Sep 1, 2019 | National Cancer Institute (NCI), Yale University |
| NCT03266159 | Phase 2 | Nov 27, 2017 | GlaxoSmithKline |
| NCT03150056 | Phase 1 | Jun 12, 2017 | GlaxoSmithKline |
| NCT02964507 | Phase 2 | Feb 2, 2017 | GlaxoSmithKline |
| NCT02706535 | Phase 1 | May 1, 2016 | GlaxoSmithKline |
| NCT01943851 | Phase 1 | May 14, 2014 | GlaxoSmithKline |
| NCT01587703 | Phase 1 | Mar 28, 2012 | GlaxoSmithKline |
| NCT03702036 | N/A | — | GlaxoSmithKline |
Showing 9 of 9 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 7 | 7 | 3 | 2012 |
| National Cancer Institute (NCI) | Government | 2 | 2 | 2 | 2019 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Yale University | Academic/Hospital | 1 | 0 | 1 | 2019 |
4 organizations
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