tiragolumab
mAbexperimental
Clinical trial activity
52 trials · 24 clinical orgs · 0 marketing orgs
Phase 1
16
Phase 2
45
Phase 3
8
Phase 4
0
Earliest trial started May 23, 2016 (NCT02794571)
Timeline
Indications
Studied for
- Breast Neoplasms · Phase 2
- Carcinoma, Hepatocellular · Phase 3
- Carcinoma, Non-Small-Cell Lung · Phase 3
- Carcinoma, Renal Cell · Phase 2
- Carcinoma, Squamous Cell · Phase 2
- Carcinoma, Transitional Cell · Phase 2
- Chordoma · Phase 1/Phase 2
- Colorectal Neoplasms · Phase 2
- Esophageal Neoplasms · Phase 3
- Esophageal Squamous Cell Carcinoma · Phase 3
- Glioblastoma · Phase 2
- Head and Neck Neoplasms · Phase 2
- Kidney Neoplasms · Phase 1/Phase 2
- Liver Neoplasms · Phase 1/Phase 2
- Lung Neoplasms · Phase 2
- Lymphoma, B-Cell · Phase 1
- Lymphoma, Non-Hodgkin · Phase 1
- Melanoma · Phase 2
- Multiple Myeloma · Phase 1
- Neoplasm Metastasis · Phase 1
- Neoplasms · Phase 2
- Rectal Neoplasms · Phase 2
- Rhabdoid Tumor · Phase 1/Phase 2
- Sarcoma · Phase 1/Phase 2
- Small Cell Lung Carcinoma · Phase 3
- Squamous Cell Carcinoma of Head and Neck · Phase 2
- Stomach Neoplasms · Phase 2
- Triple Negative Breast Neoplasms · Phase 1
- Urinary Bladder Neoplasms · Phase 1
- Uterine Cervical Neoplasms · Phase 1/Phase 2
Mechanism of action
TIGIT antagonist
T-cell immunoreceptor with Ig and ITIM domains inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4298050 ↗
Also known as
- mtig7192a
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07258108 | Phase 2 | Nov 21, 2025 | Sun Yat-Sen University |
| NCT07038915 | Phase 2 | Jul 28, 2025 | University of Texas at Houston |
| NCT06760481 | Phase 1 | Jun 30, 2025 | University of Texas at Houston |
| NCT06754501 | Phase 2 | Jun 30, 2025 | Genentech, University of Texas at Houston |
| NCT06784947 | Phase 2 | May 31, 2025 | Genentech, University of Colorado, Denver |
| NCT06328036 | Phase 2 | Apr 30, 2025 | National Cancer Institute (NCI), University of Pittsburgh |
| NCT06713798 | Phase 2 | Jan 31, 2025 | Institut Gustave Roussy, Roche |
| NCT06331598 | Phase 2 | Nov 30, 2024 | Roche |
| NCT06603818 | Phase 2 | Nov 17, 2024 | National Cancer Institute (NCI) |
| NCT06342037 | Phase 2 | Jun 12, 2024 | Netherlands Cancer Institute, Roche |
| NCT06267001 | Phase 3 | Mar 21, 2024 | Roche |
| NCT05798663 | Phase 2 | Dec 7, 2023 | Alliance Foundation Trials, Genentech, University of Texas at Houston |
| NCT05908786 | Phase 1/Phase 2 (Phase 2) | Dec 5, 2023 | Roche |
| NCT06003621 | Phase 2 | Nov 1, 2023 | Omico, Roche, University of New South Wales |
| NCT05394337 | Early Phase 1 (Phase 1) | Nov 1, 2023 | University of Texas at Houston |
| NCT05715281 | Phase 2 | Sep 26, 2023 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
| NCT05904886 | Phase 3 | Sep 14, 2023 | Chugai, Roche |
| NCT05746481 | Phase 2 | Aug 8, 2023 | Genentech, University of Pittsburgh |
| NCT05681039 | Phase 2 | Jun 2, 2023 | Genentech, University of Texas at Houston |
| NCT05825625 | Phase 2 | May 26, 2023 | IKF Klinische Krebsforschung GmbH am Krankenhaus Nordwest, Institut für Klinische Krebsforschung IKF GmbH, Roche, University of Heidelberg |
Showing 20 of 52 trials
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Organizations
Research & Development (24)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Roche | For profit | 32 | 26 | 3 | 2016 |
| Genentech | For profit | 10 | 3 | 2 | 2016 |
| University of Texas at Houston | Academic/Hospital | 6 | 5 | 2 | 2023 |
| National Cancer Institute (NCI) | Government | 4 | 4 | 1 | 2022 |
| University of Pittsburgh | Academic/Hospital | 2 | 1 | 1 | 2023 |
| Alliance Foundation Trials | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Centre Georges Francois Leclerc | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Chugai | For profit | 1 | 0 | 1 | 2023 |
| Georgetown University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| IKF Klinische Krebsforschung GmbH am Krankenhaus Nordwest | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Institut für Klinische Krebsforschung IKF GmbH | Academic/Hospital | 1 | 0 | 1 | 2023 |
| Institut Gustave Roussy | Academic/Hospital | 1 | 1 | 1 | 2025 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2023 |
| National Taiwan University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Netherlands Cancer Institute | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Omico | For profit | 1 | 1 | 1 | 2023 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Bern | Academic/Hospital | 1 | 0 | 1 | 2023 |
| University of Colorado, Denver | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Groningen | Academic/Hospital | 1 | 1 | 1 | 2022 |
24 organizations
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