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fisetin

Small moleculeexperimental

Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols. It occurs in many plants where it serves as a yellow pigment. It is found in many fruits and vegetables, such as strawberries, apples, persimmons, onions, and cucumbers. — Wikipedia

Clinical trial activity

29 trials · 23 clinical orgs · 0 marketing orgs

Phase 1
7
Phase 2
21
Phase 3
2
Phase 4
1

Earliest trial started Jan 2, 2018 (NCT03325322)

Timeline

2010s

  1. Jan 1, 2018

    Earliest Phase 2 Sponsor(trial)

2020s

  1. Jan 1, 2020

    Earliest Phase 1 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12
Mol. weight
286.24 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07279714Phase 2Dec 31, 2025University of Toronto
NCT06819254Phase 4Dec 31, 2025Wake Forest University
NCT07195318N/ASep 24, 2025University of Copenhagen
NCT06990256N/ASep 1, 2025Abinopharm, Inc, Huazhong University of Science and Technology
NCT07025226Early Phase 1 (Phase 1)Aug 12, 2025Mayo Clinic
NCT06796374N/AFeb 1, 2025University of Greifswald
NCT06431932Phase 1/Phase 2 (Phase 2)Jan 1, 2025Mayo Clinic, University of Copenhagen, University of Southern Denmark
NCT06399809Phase 2Sep 30, 2024Northwestern University
NCT06113016Phase 2Dec 31, 2023National Cancer Institute (NCI), National Institutes of Health (NIH), University of California, Los Angeles
NCT06133634Phase 1/Phase 2 (Phase 2)Sep 25, 2023American Heart Association, University of Colorado, Boulder
NCT05758246Phase 2Aug 23, 2023University of Minnesota
NCT05482672Phase 2/Phase 3 (Phase 3)Jul 1, 2023Harvard University, University of Kentucky
NCT05505747Phase 2/Phase 3 (Phase 3)Feb 28, 2023University of Kentucky
NCT05595499Phase 2Jan 31, 2023National Cancer Institute (NCI), National Institute on Aging (NIA), University of California, Los Angeles
NCT05593588Phase 2Jan 1, 2023Mayo Clinic
NCT05276895N/ADec 1, 2022Assiut University
NCT05416515Phase 2Oct 9, 2022Mayo Clinic
NCT04770064Phase 1/Phase 2 (Phase 2)Jun 30, 2022Harvard University, University of Kentucky
NCT04733534Phase 2Nov 30, 2021National Cancer Institute (NCI), National Institutes of Health (NIH), St. Jude Children's Hospital
NCT05025956Phase 1/Phase 2 (Phase 2)Sep 30, 2021Department of Defense
Showing 20 of 29 trials
Page 1 / 2

Organizations

Research & Development (23)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Mayo ClinicAcademic/Hospital111022018
Department of DefenseGovernment3312020
National Cancer Institute (NCI)Government3012021
University of KentuckyAcademic/Hospital3222022
Harvard UniversityAcademic/Hospital2122022
National Institute on Aging (NIA)Government2012020
National Institutes of Health (NIH)Government2012021
University of California, Los AngelesAcademic/Hospital2212023
University of CopenhagenAcademic/Hospital2222025
Abinopharm, IncFor profit1012025
American Heart AssociationAcademic/Hospital1012023
Assiut UniversityAcademic/Hospital1112022
Huazhong University of Science and TechnologyAcademic/Hospital1112025
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)Government1012021
Northwestern UniversityAcademic/Hospital1112024
St. Jude Children's HospitalAcademic/Hospital1112021
United States NavyGovernment1012020
University of Colorado, BoulderAcademic/Hospital1112023
University of GreifswaldAcademic/Hospital1112025
University of MinnesotaAcademic/Hospital1112023
23 organizations
Page 1 / 2