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sintilimab

mAbexperimental

Sintilimab, sold under the brand Tyvyt among others, is a medication used to treat Hodgkin's disease, and has been approved in China. — Wikipedia

Clinical trial activity

465 trials · 136 clinical orgs · 0 marketing orgs

Phase 1
83
Phase 2
386
Phase 3
50
Phase 4
6

Earliest trial started Oct 1, 2016 (NCT02937116)

Timeline

2010s

  1. Jan 1, 2016

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2017

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2017

    Earliest Phase 3 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

C=CC(=O)N1CCN2c3c(c(=O)n(-c4c(C)ccnc4C(C)C)c4nc(-c5c(O)cccc5F)c(Cl)cc34)N(C)C(=O)[C@H]2C1
Mol. weight
617.08 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Multi-specific
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • ibi308

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07310771Phase 2Jan 10, 2026Fujian Medical University
NCT07309952Phase 2Dec 31, 2025Sun Yat-Sen University
NCT07254858Phase 2Dec 31, 2025Wenzhou Medical University
NCT07268677Phase 2Dec 1, 2025Fudan University
NCT07156019Phase 2Oct 31, 2025Chinese Academy of Medical Sciences
NCT07179900Phase 2Oct 31, 2025Hebei University
NCT07263386Phase 2Oct 23, 2025Nanjing Medical University
NCT07018063Phase 2Oct 1, 2025Peking University
NCT07088731Phase 2Sep 30, 2025Chinese Academy of Medical Sciences
NCT07194005Phase 2Sep 4, 2025Fudan University
NCT07120698Phase 2Aug 26, 2025China Medical University, Guangdong Association of Clinical Trials, Shantou University, Suining Central Hospital, Zunyi Medical College
NCT07053150Phase 2Aug 15, 2025Hengrui Therapeutics, Inc., Huazhong University of Science and Technology, Innovent Biologics (Suzhou) Co. Ltd.
NCT07061535Phase 2Aug 1, 2025Innovent Biologics (Suzhou) Co. Ltd., Zhejiang University
NCT07077798N/AAug 1, 2025Huazhong University of Science and Technology
NCT07079410Phase 2Jul 31, 2025Fudan University
NCT07038460Phase 2Jul 31, 2025Shantou University
NCT06973330Phase 2Jul 31, 2025Anhui Medical University
NCT07022301Phase 2Jul 31, 2025Wannan Medical College
NCT07067450N/AJul 20, 2025Sichuan University
NCT07077512Phase 2Jul 15, 2025Guangzhou Medical University, Guangzhou University of Chinese Medicine, Sun Yat-Sen University
Showing 20 of 465 trials
Page 1 / 24

Organizations

Research & Development (136)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Innovent Biologics (Suzhou) Co. Ltd.For profit714342016
Sun Yat-Sen UniversityAcademic/Hospital696542019
Fudan UniversityAcademic/Hospital504552019
Chinese Academy of Medical SciencesAcademic/Hospital453742017
Huazhong University of Science and TechnologyAcademic/Hospital251952019
Tianjin Medical UniversityAcademic/Hospital232042019
Jiao Tong UniversityAcademic/Hospital211852018
Sichuan UniversityAcademic/Hospital211942019
Zhejiang UniversityAcademic/Hospital201832019
Peking UniversityAcademic/Hospital18942019
Nanjing Medical UniversityAcademic/Hospital171432017
Guangzhou Medical UniversityAcademic/Hospital151242019
Central South UniversityAcademic/Hospital13842019
People's Liberation Army of ChinaGovernment131132019
Shandong UniversityAcademic/Hospital12942018
Henan Medical UniversityAcademic/Hospital10822019
Capital Medical UniversityAcademic/Hospital9432019
Fujian Medical UniversityAcademic/Hospital9832019
Zhengzhou UniversityAcademic/Hospital8422020
China Three Gorges University, Yichang, ChinaAcademic/Hospital7612019
136 organizations
Page 1 / 7