dihomo-gamma-linolenic acid
Small moleculeexperimental
γ-Linolenic acid or GLA is an n−6, or omega-6, fatty acid found primarily in seed oils. When acting on GLA, arachidonate 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of arachidonic acid to leukotrienes is inhibited. — Wikipedia
Clinical trial activity
5 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
0
Phase 4
2
Earliest trial started Sep 1, 1994 (NCT00004420)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 2 Sponsor(trial)
Indications
Approved for
Mechanism of action
- CyclooxygenaseSUBSTRATE
Cyclooxygenase substrate
Chemistry & pharmacology
Loading structure…
SMILES
CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O- Mol. weight
- 278.44 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaΓ-Linolenic acid ↗
- ChEMBLCHEMBL465183 ↗
- ChEMBLCHEMBL464982 ↗
- WikipediaGamma-Linolenic acid ↗
- WikipediaDihomo-γ-linolenic acid ↗
Also known as
- dihomo-gamma-linolenic acid
- efamast
- efamast 40
- efamast 80
- efamol
- efamol g
- epogam
- epogam
- epogam
- epogam 1000
- epogam 40
- epogam 80
- epogam paed
- evening primrose oil
- gamma linoleic acid
- gamma linoleic acid
- gamma-linolenic acid
- gamma-linolenic acid
- gamma-linolenic acid
- gamma-linolenic acid
- gamma-linolenic acid
- gamma-linolenic acid
- gammolin
- gam-o
- gamolenic
- gamolenic acid
- gamolenic acid
- gamolenic acid
- gamolenic acid
- gamophase
- kentogam
- lin-gam
- naudicelle
- preglandin
- unigam
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04481724 | N/A | Jul 22, 2020 | Virta Health |
| NCT00878670 | Phase 4 | Mar 1, 2009 | Max Zeller Soehne AG, University of Zurich |
| NCT01179971 | Phase 2 | Dec 1, 2008 | Friedrich Schiller University, Humboldt University |
| NCT00329680 | Phase 4 | Jun 1, 2007 | Abbott, Fernandes Tavora Hospital |
| NCT00004420 | N/A | Sep 1, 1994 | Food and Drug Administration, University of Massachusetts |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Abbott | For profit | 1 | 0 | 1 | 2007 |
| Fernandes Tavora Hospital | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Food and Drug Administration | Government | 1 | 1 | 1 | 1994 |
| Friedrich Schiller University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Humboldt University | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Max Zeller Soehne AG | For profit | 1 | 1 | 1 | 2009 |
| University of Massachusetts | Academic/Hospital | 1 | 0 | 1 | 1994 |
| University of Zurich | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Virta Health | Academic/Hospital | 1 | 1 | 1 | 2020 |
9 organizations
Page 1 / 1