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dopamine

Trade name: intropin

Small moleculeapproved

Approved

Feb 25, 1974

Dopamine, a sympathomimetic amine vasopressor, is the naturally occurring immediate precursor of norepinephrine. G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension. Dopamine HCl is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure. — NCATS

Clinical trial activity

77 trials · 122 clinical orgs · 15 marketing orgs

Phase 1
15
Phase 2
28
Phase 3
15
Phase 4
18

Earliest trial started Mar 1, 2000 (NCT00218075)

Timeline

1970s

  1. Feb 25, 1974

    Abbott — Earliest FDA Approval

  2. Feb 25, 1974

    Hospira — NDA Secondary Org

  3. Feb 25, 1974

    Abbott — NDA Organization

1980s

  1. May 19, 1981

    International Medication — NDA Secondary Org

  2. Jul 6, 1981

    Baxalta — NDA Secondary Org

  3. Jul 6, 1981

    Baxter — NDA Secondary Org

  4. Jun 28, 1983

    Teligent Pharmaceuticals — NDA Secondary Org

  5. Oct 23, 1985

    Teligent Pharmaceuticals — Marketing Organization

  6. Oct 15, 1986

    B. Braun — NDA Secondary Org

  7. Feb 11, 1987

    Lutipold — Marketing Organization

  8. Feb 11, 1987

    Sankyo — Marketing Organization

1990s

  1. Oct 23, 1991

    Teva — Marketing Organization

  2. May 23, 1996

    Hospira — Marketing Organization

2000s

  1. Jan 1, 2000

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2001

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

2010s

  1. Apr 11, 2018

    Hikma — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedPriority reviewFeb 25, 1974

Chemistry & pharmacology

Loading structure…

SMILES

NCCc1ccc(O)c(O)c1
Mol. weight
153.18 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 2-(3,4-dihydroxyphenyl)ethylamine
  • 2-(3,4-dihydroxyphenyl)ethylamine
  • 3,4-dihydroxyphenethylamine
  • 3,4-dihydroxyphenethylamine
  • 3-hydroxytyramine
  • 3-hydroxytyramine
  • 4-(2-aminoethyl)-1,2-benzenediol
  • 4-(2-aminoethyl)-1,2-benzenediol
  • 4-(2-aminoethyl)benzene-1,2-diol
  • 4-(2-aminoethyl)benzene-1,2-diol
  • 4-(2-aminoethyl)catechol
  • 4-(2-aminoethyl)catechol
  • 4-(2-aminoethyl)pyrocatechol
  • 4-(2-aminoethyl)pyrocatechol
  • asl-279
  • asl-279
  • carbidopa
  • carbidopa - levodopa
  • carbidopa, levodopa drug combination
  • carbilev
  • deoxyepinephrine
  • deoxyepinephrine
  • dopamin
  • dopamin
  • dopamin
  • dopamina
  • dopamina
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine
  • dopamine hcl
  • dopamine hcl
  • dopamine hcl
  • dopamine hydrochloride
  • dopamine hydrochloride
  • dopamine hydrochloride
  • dopamine hydrochloride
  • dopamine hydrochloride
  • dopamin-natterman
  • dopaminum
  • dopaminum
  • dophamine
  • dophamine
  • dophamine
  • dopmin
  • duodopa
  • dynatra
  • dynatra
  • grifoparkin
  • hydroxytyramin
  • hydroxytyramin
  • hydroxytyramin
  • hydroxytyramine
  • hydroxytyramine
  • intropin
  • intropin
  • intropin
  • ipx066
  • ipx066
  • ipx066
  • l-dopamine
  • l-dopamine
  • nacom
  • nakom
  • numient
  • oxytyramine
  • oxytyramine
  • oxytyramine
  • parcopa
  • parcopa
  • parcopa
  • rytary
  • sabax dopamin
  • selectajet
  • sinemet
  • sinemet
  • sinemet
  • sinemet
  • sinemet
  • sinemet cr
  • sinemet cr4
  • tidomed

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07214285Phase 1/Phase 2 (Phase 2)Oct 1, 2025University of Lille
NCT07111442N/AAug 30, 2025Peking University
NCT07273526N/AJun 1, 2025University of Health Sciences Lahore
NCT06611423Phase 1Oct 15, 2024AstraZeneca, Clinical Trial Consultants AB, Karolinska Institute
NCT06447740N/AJun 3, 2024Peking University
NCT05732077N/AJan 31, 2023Peking University
NCT04750070Phase 3Oct 31, 2021International Center for Diarrheal Disease Research, Muhimbili University, University of British Columbia
NCT06784570Phase 2Jan 1, 2021Zagazig University
NCT04536194Phase 3Oct 10, 2020Fudan University
NCT04332276Phase 1/Phase 2 (Phase 2)Sep 30, 2020University of Lille
NCT04369573Phase 4May 4, 2020University of Milan
NCT04525495Phase 2Apr 1, 2020Seoul National University, University of Ulsan, Yonsei University
NCT03892447Phase 4Aug 1, 2019Shengjing Hospital
NCT03933930N/AMay 6, 2019Taipei Medical University
NCT03243552Phase 2Aug 31, 2017National Institutes of Health (NIH), University of California, Los Angeles
NCT03170739Phase 4Jun 6, 2017Husson University, Sun Yat-Sen University
NCT03107858Phase 2/Phase 3 (Phase 3)May 1, 2017Assiut University
NCT03115827Phase 4Apr 18, 2017American Academy of Neurology, Lundbeck, Vanderbilt University
NCT03780686N/AApr 9, 2017Ain Shams University
NCT02726620N/AJan 1, 2017Utrecht University, Vanderbilt University
Showing 20 of 77 trials
Page 1 / 4

Organizations

Research & Development (122)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
BialFor profit6622001
Impax LaboratoriesFor profit6622008
National Institutes of Health (NIH)Government4032007
Emory UniversityAcademic/Hospital3222007
Peking UniversityAcademic/Hospital3312023
University of MilanAcademic/Hospital3322011
Vanderbilt UniversityAcademic/Hospital3222015
Acorda TherapeuticsFor profit2222012
Duke UniversityAcademic/Hospital2122009
Fudan UniversityAcademic/Hospital2222011
GlaxoSmithKlineFor profit2212007
Michael J. Fox Foundation for Parkinson's ResearchAcademic/Hospital2022011
Orion CorporationFor profit2222008
Queen's University, BelfastAcademic/Hospital2022013
The University of Texas, DallasAcademic/Hospital2022000
University of AlbertaAcademic/Hospital2122015
University of LilleAcademic/Hospital2212020
University of Texas at HoustonAcademic/Hospital2122000
University of ThessalyAcademic/Hospital2212009
XenoPort, Inc.For profit2212009
122 organizations
Page 1 / 7

Marketing (20)

OrganizationOrg typeRelationshipDate
AbbottFor profitNDAFeb 25, 1974
AbbottFor profitMKTG—
AbraxisFor profitMKTG—
B. BraunFor profitNDA2Oct 15, 1986
BaxaltaFor profitNDA2Jul 6, 1981
BaxterFor profitNDA2Jul 6, 1981
HikmaFor profitMKTGApr 11, 2018
HospiraFor profitNDA2Feb 25, 1974
HospiraFor profitMKTGMay 23, 1996
International MedicationFor profitNDA2May 19, 1981
LutipoldFor profitMKTGFeb 11, 1987
Lyphomed, Inc.For profitNDA2—
SankyoFor profitMKTGFeb 11, 1987
Smith & NephewFor profitMKTG—
Teligent PharmaceuticalsFor profitNDA2Jun 28, 1983
Teligent PharmaceuticalsFor profitSYNOct 23, 1985
Teligent PharmaceuticalsFor profitMKTGOct 23, 1985
TevaFor profitMKTGOct 23, 1991
Warner ChilcottFor profitNDA2—
Warner ChilcottFor profitMKTG—