oxtriphylline
Trade name: choledyl
Small moleculeapproved
Approved
Jun 1, 1940
Choline theophyllinate (INN), also known as oxtriphylline, is a cough medicine derived from xanthine that acts as a bronchodilator to open up airways in the lung. Chemically, it is a salt of choline and theophylline. It classifies as an expectorant. The drug is available under the brand names Choledyl and Choledyl SA, among others. — Wikipedia
Clinical trial activity
0 trials · 0 clinical orgs · 4 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1940s
- Jun 1, 1940
Parke-Davis — Earliest FDA Approval
- Jun 1, 1940
Parke-Davis — NDA Organization
1980s
- Nov 5, 1981
Warner Chilcott — Marketing Organization
Indications
Approved for
Mechanism of action
- Adenosine receptorANTAGONIST
Adenosine receptor antagonist
- Adenosine receptor A1 (ADORA1) ↗
- Adenosine receptor A2b (ADORA2B) ↗
- Adenosine receptor A3 (ADORA3) ↗
- Adenosine receptor A2a (ADORA2A) ↗
- Adenosine A1 receptor
- Adenosine A2a receptor
- Adenosine A2b receptor
- Adenosine A3 receptor
- Adenosine A2 receptor
- Adenosine receptors; A1 & A3
- Adenosine receptors; A2a & A3
- Adenosine receptors; A2b & A3
- Adenosine receptors; A1 & A2
- Adenosine receptors; A1 & A2b
- Adenosine receptors; A1 & A2a
- Adenosine receptors; A2a & A2b
- Phosphodiesterase 3INHIBITOR
Phosphodiesterase 3 inhibitor
- Phosphodiesterase 4INHIBITOR
Phosphodiesterase 4 inhibitor
Approval history
- approvedJun 1, 1940
Chemistry & pharmacology
Loading structure…
SMILES
C[N+](C)(C)CCO.Cn1c(=O)c2[n-]cnc2n(C)c1=O- Mol. weight
- 283.33 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaCholine theophyllinate ↗
- ChEMBLCHEMBL1200434 ↗
Also known as
- brondaxin
- brondecon
- choledyl
- choledyl
- choledyl
- choledyl
- choledyl sa
- choledyl sa
- choledyl-sa
- cholinetheophyllinate
- choline theophyllinate
- choline theophyllinate
- choline theophyllinate
- choline theophyllinate
- choline theophyllinate
- choline theophylline
- choline theophylline
- choline theophylline
- cholinophyllin
- cholinophylline
- euspirax
- oxtriphylline
- oxtriphylline
- oxtriphylline
- oxtriphylline
- oxtriphylline
- oxtriphylline
- oxtriphylline
- oxtriphylline pediatric
- oxtripylline-sa
- sabidal
- sabidal
- theobret
- theocolin
- theocolin
- theophyline - choline mixt
- theophyline - choline mixt
- theophylline cholinate
Organizations
Marketing (4)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Morton Grove Pharmaceuticals | For profit | MKTG | — |
| Parke-Davis | For profit | NDA | Jun 1, 1940 |
| Warner Chilcott | For profit | MKTG | Nov 5, 1981 |
| Watson Pharmaceuticals | For profit | MKTG | — |