aminophylline
Trade name: aminophyllin
Approved
Apr 19, 1940
Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate. — Wikipedia
Clinical trial activity
33 trials · 38 clinical orgs · 41 marketing orgs
Earliest trial started Jan 1, 2001 (NCT00312273)
Timeline
1940s
- Apr 19, 1940
G D Searle — Earliest FDA Approval
- Apr 19, 1940
G D Searle — NDA Secondary Org
- Apr 19, 1940
G D Searle — NDA Organization
1970s
- Nov 26, 1975
Hikma — Marketing Organization
- Dec 17, 1975
Lannett Company, Inc. — Marketing Organization
- Dec 17, 1975
Chartwell Pharmaceuticals — Marketing Organization
- Mar 16, 1976
Impax Laboratories — Marketing Organization
- May 28, 1976
Bausch Health Companies — Marketing Organization
- Jun 15, 1976
Halsey — Marketing Organization
- Oct 27, 1976
Lumara Health — Marketing Organization
- Dec 22, 1976
Ani Pharmaceuticals — Marketing Organization
- Dec 22, 1976
IDT Australia Ltd. — Marketing Organization
- Nov 21, 1979
Pharmaceutical Research Associates, Inc. (PRA) — Marketing Organization
1980s
- Sep 30, 1980
Fisons — Marketing Organization
- Feb 11, 1981
Elkins Sinn — Marketing Organization
- Apr 16, 1981
Lutipold — Marketing Organization
- Aug 27, 1981
Sankyo — Marketing Organization
- Nov 10, 1981
Lyphomed, Inc. — Marketing Organization
- Feb 1, 1982
International Medication — Marketing Organization
- Feb 9, 1982
Roxane Laboratories — Marketing Organization
- Feb 9, 1982
Boehringer Ingelheim — Marketing Organization
- Feb 24, 1982
Watson Pharmaceuticals — Marketing Organization
- Apr 16, 1982
Actavis — Marketing Organization
- May 24, 1982
G D Searle — Marketing Organization
- Jul 23, 1982
Hospira — NDA Secondary Org
- Jul 23, 1982
Hospira — Marketing Organization
- Jan 3, 1983
Cosette — Marketing Organization
- Jan 3, 1983
G & W Laboratories Inc. — Marketing Organization
- Jan 3, 1983
ACP Nimble — Marketing Organization
- Mar 31, 1983
Duramed Research — Marketing Organization
- Aug 19, 1983
Barr Laboratories — Marketing Organization
- Oct 3, 1983
Vanguard — Marketing Organization
- Dec 15, 1983
Norwich Eaton Company — Marketing Organization
- Dec 15, 1983
Procter and Gamble — Marketing Organization
1990s
- Sep 25, 1991
Teva — Marketing Organization
2010s
- Jan 1, 2010
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Studied for
- Acute Kidney Injury · Phase 4
- Altitude Sickness · Phase 1
- Ambulatory Surgical Procedures · Phase 3
- Anesthesia · Phase 4
- Coronary Artery Disease · Phase 4
- Heart Arrest · Phase 2
- Heart Diseases · Phase 4
- Hypertension, Pulmonary · Phase 1
- Iron Overload · Phase 1/Phase 2
- Kidney Diseases · Phase 2/Phase 3
- Kidney Neoplasms · Phase 4
- Obstetric Labor, Premature · Phase 1
- Post-Dural Puncture Headache · Phase 4
- Postoperative Complications · Phase 3
- Pulmonary Disease, Chronic Obstructive · Phase 4
- Renal Insufficiency, Chronic · Phase 4
- Urinary Bladder Neoplasms · Early Phase 1
Mechanism of action
- Adenosine receptorANTAGONIST
Adenosine receptor antagonist
- Adenosine receptor A1 (ADORA1) ↗
- Adenosine receptor A2b (ADORA2B) ↗
- Adenosine receptor A3 (ADORA3) ↗
- Adenosine receptor A2a (ADORA2A) ↗
- Adenosine A1 receptor
- Adenosine A2a receptor
- Adenosine A2b receptor
- Adenosine A3 receptor
- Adenosine A2 receptor
- Adenosine receptors; A1 & A3
- Adenosine receptors; A2a & A3
- Adenosine receptors; A2b & A3
- Adenosine receptors; A1 & A2
- Adenosine receptors; A1 & A2b
- Adenosine receptors; A1 & A2a
- Adenosine receptors; A2a & A2b
- Phosphodiesterase 3INHIBITOR
Phosphodiesterase 3 inhibitor
- Phosphodiesterase 4INHIBITOR
Phosphodiesterase 4 inhibitor
Approval history
- approvedApr 19, 1940
Chemistry & pharmacology
SMILES
Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN- Mol. weight
- 420.43 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral, Topical
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
Yes
Sources
- WikipediaAminophylline ↗
- ChEMBLCHEMBL1370561 ↗
Also known as
- aminophyllin
- aminophyllin
- aminophyllin
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline
- aminophylline dihydrate
- aminophylline dye free
- aminophylline dye free
- aminophylline hydrate
- aminophylline hydrate
- aminophylline in sodium chloride
- ammophyllin
- ammophyllin
- amnivent-225 sr
- amnivent-350 sr
- armophylline
- cetraphylline
- chronophyllin
- duraphyllin
- elixophylline
- etheophyl
- peterphyllin
- peterphyllin
- phyllocontin
- phyllocontin
- phyllocontin
- pseudotheophylline
- somophyllin
- somophyllin
- somophyllin
- somophyllin-crt
- somophyllin-df
- somophyllin-df
- somophyllin-t
- theophyllamine
- theophyllamine
- theophylline ethylenediamine
- theophylline ethylenediamine
- theophylline ethylenediamine
- theophylline monohydrate
- throphylline
- truphylline
- truphylline
- xanthium
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07011134 | Phase 3 | Jun 15, 2025 | Cairo University |
| NCT06830577 | N/A | Mar 1, 2025 | Ain Shams University |
| NCT06196853 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2024 | Mahidol University, Siriraj Hospital |
| NCT06125665 | N/A | Nov 11, 2023 | Tanta University |
| NCT05933642 | Phase 2/Phase 3 (Phase 3) | Jul 2, 2023 | University of Malaya |
| NCT05738135 | N/A | Feb 25, 2023 | Tanta University |
| NCT05705050 | N/A | Feb 15, 2023 | Tanta University |
| NCT05655806 | Phase 4 | Dec 30, 2022 | Cairo University |
| NCT05552404 | Phase 4 | Oct 1, 2022 | Ain Shams University |
| NCT04151381 | Phase 1 | Nov 30, 2019 | Beni Suef University |
| NCT04101500 | Phase 4 | Apr 1, 2019 | Huazhong University of Science and Technology |
| NCT03897335 | Phase 3 | Feb 7, 2019 | University of Tennessee |
| NCT03997006 | Phase 4 | Jan 1, 2019 | Damanhour University |
| NCT03296579 | N/A | Jun 30, 2018 | Postgraduate Institute of Medical Education and Research, University of British Columbia |
| NCT03152942 | Phase 1 | Aug 1, 2017 | Action Medical Research, St Stephens Aids Trust, University of London |
| NCT02983422 | Early Phase 1 (Phase 1) | Dec 1, 2016 | Jiao Tong University |
| NCT02522013 | Phase 3 | Oct 1, 2015 | Hebei University, Henan University of Traditional Chinese Medicine, Jinzhou central hospital, Soochow University, Zhengzhou University |
| NCT01794078 | Phase 1 | Sep 1, 2013 | Department of Defense, Duke University |
| NCT01759862 | N/A | Nov 1, 2012 | Stanford University |
| NCT01655524 | Phase 4 | Jul 1, 2012 | Rush University |
Organizations
Research & Development (38)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Rush University | Academic/Hospital | 3 | 3 | 1 | 2010 |
| Tanta University | Academic/Hospital | 3 | 3 | 1 | 2023 |
| Ain Shams University | Academic/Hospital | 2 | 2 | 2 | 2022 |
| Cairo University | Academic/Hospital | 2 | 2 | 2 | 2022 |
| Defense Advanced Research Projects Agency | Government | 2 | 0 | 2 | 2011 |
| Duke University | Academic/Hospital | 2 | 2 | 1 | 2012 |
| Stanford University | Academic/Hospital | 2 | 2 | 1 | 2010 |
| University of British Columbia | Academic/Hospital | 2 | 2 | 2 | 2001 |
| University of Colorado, Denver | Academic/Hospital | 2 | 0 | 2 | 2011 |
| Action Medical Research | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Beni Suef University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Colorado State University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Damanhour University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Department of Defense | Government | 1 | 0 | 1 | 2013 |
| Heart and Stroke Foundation of Canada | Academic/Hospital | 1 | 0 | 1 | 2001 |
| Hebei University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Henan University of Traditional Chinese Medicine | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Jiao Tong University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Jinzhou central hospital | Academic/Hospital | 1 | 0 | 1 | 2015 |
Marketing (46)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| ACP Nimble | For profit | MKTG | Jan 3, 1983 |
| Abraxis | For profit | MKTG | — |
| Actavis | For profit | MKTG | Apr 16, 1982 |
| Ani Pharmaceuticals | For profit | MKTG | Dec 22, 1976 |
| Ani Pharmaceuticals | For profit | SYN | Dec 22, 1976 |
| Ascot Pharmaceuticals | For profit | MKTG | — |
| Barr Laboratories | For profit | MKTG | Aug 19, 1983 |
| Bausch Health Companies | For profit | MKTG | May 28, 1976 |
| Boehringer Ingelheim | For profit | MKTG | Feb 9, 1982 |
| Chartwell Pharmaceuticals | For profit | MKTG | Dec 17, 1975 |
| Cosette | For profit | MKTG | Jan 3, 1983 |
| Duramed Research | For profit | MKTG | Mar 31, 1983 |
| Elkins Sinn | For profit | MKTG | Feb 11, 1981 |
| Fisons | For profit | MKTG | Sep 30, 1980 |
| Fisons | For profit | NDA2 | — |
| G & W Laboratories Inc. | For profit | MKTG | Jan 3, 1983 |
| G D Searle | For profit | NDA2 | Apr 19, 1940 |
| G D Searle | For profit | NDA | Apr 19, 1940 |
| G D Searle | For profit | MKTG | May 24, 1982 |
| Halsey | For profit | MKTG | Jun 15, 1976 |
| Hikma | For profit | MKTG | Nov 26, 1975 |
| Hospira | For profit | NDA2 | Jul 23, 1982 |
| Hospira | For profit | MKTG | Jul 23, 1982 |
| IDT Australia Ltd. | For profit | MKTG | Dec 22, 1976 |
| Impax Laboratories | For profit | MKTG | Mar 16, 1976 |
| International Medication | For profit | MKTG | Feb 1, 1982 |
| King Pharmaceuticals | For profit | MKTG | — |
| Lannett Company, Inc. | For profit | MKTG | Dec 17, 1975 |
| Lumara Health | For profit | MKTG | Oct 27, 1976 |
| Lutipold | For profit | MKTG | Apr 16, 1981 |
| Lyphomed, Inc. | For profit | MKTG | Nov 10, 1981 |
| Morton Grove Pharmaceuticals | For profit | MKTG | — |
| Norwich Eaton Company | For profit | MKTG | Dec 15, 1983 |
| Panray Corp. | For profit | MKTG | — |
| Pharmaceutical Research Associates, Inc. (PRA) | For profit | MKTG | Nov 21, 1979 |
| Procter and Gamble | For profit | MKTG | Dec 15, 1983 |
| Puracap Pharmaceutical | For profit | MKTG | — |
| Roxane Laboratories | For profit | MKTG | Feb 9, 1982 |
| Sankyo | For profit | MKTG | Aug 27, 1981 |
| Smith & Nephew | For profit | MKTG | — |
| Tablicaps | For profit | MKTG | — |
| Teva | For profit | MKTG | Sep 25, 1991 |
| VALE | For profit | MKTG | — |
| Vanguard | For profit | MKTG | Oct 3, 1983 |
| Vintage | For profit | MKTG | — |
| Watson Pharmaceuticals | For profit | MKTG | Feb 24, 1982 |