batefenterol
Small moleculeexperimental
Clinical trial activity
13 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
6
Phase 3
1
Phase 4
0
Earliest trial started Nov 1, 2005 (NCT00887406)
Timeline
Indications
Mechanism of action
- Beta-2 adrenergic receptorAGONIST
ADRB2 agonist
- Muscarinic acetylcholine receptor M2ANTAGONIST
CHRM2 antagonist
- Muscarinic acetylcholine receptor M3ANTAGONIST
CHRM3 antagonist
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12- Mol. weight
- 740.26 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3039518 ↗
Also known as
- batefenterol
- batefenterol
- batefenterol
- batefenterol
- gsk961081
- gsk961081
- gsk961081
- gsk961081a
- gsk961081a
- td-5959
- td-5959
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02663089 | Phase 1 | Feb 8, 2016 | GlaxoSmithKline, Hammersmith Medicines Research |
| NCT02666287 | Phase 1 | Jan 27, 2016 | GlaxoSmithKline, Hammersmith Medicines Research |
| NCT02573870 | Phase 2 | Dec 1, 2015 | GlaxoSmithKline |
| NCT02570165 | Phase 2 | Nov 1, 2015 | GlaxoSmithKline |
| NCT02577926 | Phase 3 | Oct 1, 2015 | Novartis, RWTH Aachen University |
| NCT02064504 | Phase 1 | Feb 19, 2014 | GlaxoSmithKline |
| NCT01449799 | Phase 1 | Jul 1, 2011 | GlaxoSmithKline |
| NCT01319019 | Phase 2 | Dec 1, 2010 | GlaxoSmithKline |
| NCT00674817 | Phase 2 | Apr 1, 2008 | GlaxoSmithKline |
| NCT00687700 | Phase 1 | Mar 1, 2008 | GlaxoSmithKline |
| NCT00550225 | Phase 1 | Nov 1, 2007 | GlaxoSmithKline |
| NCT00478738 | Phase 2 | Jun 1, 2007 | GlaxoSmithKline |
| NCT00887406 | Phase 1 | Nov 1, 2005 | GlaxoSmithKline |
Showing 13 of 13 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 12 | 12 | 2 | 2005 |
| Hammersmith Medicines Research | For profit | 2 | 0 | 1 | 2016 |
| Novartis | For profit | 1 | 0 | 1 | 2015 |
| RWTH Aachen University | Academic/Hospital | 1 | 1 | 1 | 2015 |
4 organizations
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