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dilevalol

Small moleculeexperimental

Clinical trial activity

0 trials · 0 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0

Mechanism of action

  • Beta-2 adrenergic receptorAGONIST

    ADRB2 agonist

    Dilevalol is a nonselective, Beta-adrenergic receptor antagonist with, Beta 2-adrenergic receptor agonist activity. It has three to six times the activity of labetalol at the Beta-receptor, but unlike labetalol, little activity at the Alpha 1-receptor. In animal studies, it causes vasodilation even in denervated limbs, which is blocked by propranolol, suggesting that these vasodilator effects are due to Beta 2-adrenergic receptor agonism. It lowers blood pressure, both in normal and hypertensive subjects. Because the fall in blood pressure correlates with a fall in peripheral vascular resistance rather than a decrease in cardiac index, it is thought to be due to the Beta 2-adrenergic receptor agonist induced vasodilation, rather than to non-specific, Beta-adrenergic receptor antagonist effects.

  • Adrenergic receptor betaANTAGONIST

    Adrenergic receptor beta antagonist

    Dilevalol is a nonselective, Beta-adrenergic receptor antagonist with, Beta 2-adrenergic receptor agonist activity. It has three to six times the activity of labetalol at the Beta-receptor, but unlike labetalol, little activity at the Alpha 1-receptor. In animal studies, it causes vasodilation even in denervated limbs, which is blocked by propranolol, suggesting that these vasodilator effects are due to Beta 2-adrenergic receptor agonism. It lowers blood pressure, both in normal and hypertensive subjects. Because the fall in blood pressure correlates with a fall in peripheral vascular resistance rather than a decrease in cardiac index, it is thought to be due to the Beta 2-adrenergic receptor agonist induced vasodilation, rather than to non-specific, Beta-adrenergic receptor antagonist effects.

Chemistry & pharmacology

Loading structure…

SMILES

C[C@H](CCc1ccccc1)NC[C@H](O)c1ccc(O)c(C(N)=O)c1
Mol. weight
328.41 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • dilevalol
  • dilevalol
  • dilevalol
  • dilevalol
  • dilevalol
  • dilevalol hcl
  • dilevalol hcl
  • dilevalol hydrochloride
  • dilevalol hydrochloride
  • dilevalon
  • (+)-labetalol
  • levadil
  • sch-19927
  • sch-19927
  • sch-19927