hexylcaine
Trade name: cyclaine
Small moleculeapproved
Hexylcaine hydrochloride, a benzoic acid ester, is a local anaesthetic that has been used for surface anaesthesia of mucous membranes. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve. — NCATS
Clinical trial activity
0 trials · 0 clinical orgs · 2 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
0
Timeline
1940s
- Jun 1, 1949
Sharp & Dohme — First NDA Organization
- Jun 1, 1949
Sharp & Dohme — NDA Organization
Indications
Approved for
Mechanism of action
- Sodium channel alpha subunitBLOCKER
Sodium channel alpha subunit blocker
- Sodium channel protein type 1 subunit alpha (SCN1A) ↗
- Sodium channel protein type 5 subunit alpha (SCN5A) ↗
- Sodium channel protein type 4 subunit alpha (SCN4A) ↗
- Sodium channel protein type 7 subunit alpha (SCN7A) ↗
- Sodium channel protein type 2 subunit alpha (SCN2A) ↗
- Sodium channel protein type 9 subunit alpha (SCN9A) ↗
- Sodium channel protein type 3 subunit alpha (SCN3A) ↗
- Sodium channel protein type 11 subunit alpha (SCN11A) ↗
- Sodium channel protein type 8 subunit alpha (SCN8A) ↗
- Sodium channel protein type 10 subunit alpha (SCN10A) ↗
- Sodium channel protein type I alpha subunit
- Sodium channel protein type V alpha subunit
- Sodium channel protein type IV alpha subunit
- Sodium channel protein type VII alpha subunit
- Sodium channel protein type IX alpha subunit
- Sodium channel protein type II alpha subunit
- Sodium channel protein type III alpha subunit
- Sodium channel protein type XI alpha subunit
- Sodium channel protein type VIII alpha subunit
- Sodium channel protein type X alpha subunit
- Sodium channel alpha subunits; brain (Types I, II, III)
Approval history
- approved—
Chemistry & pharmacology
Loading structure…
SMILES
CC(CNC1CCCCC1)OC(=O)c1ccccc1- Mol. weight
- 261.36 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- ChEMBLCHEMBL1197 ↗
- WikipediaHexylcaine ↗
- NCATS511IU0826Z ↗
- ChEMBLCHEMBL1200715 ↗
Also known as
- cyclain
- cyclaine
- cyclaine
- cyclaine
- cyclaine
- cyclaine /od/ 1-(cyclohexylamino)-2-propanol benzoate ester
- hexilcaina
- hexilcaina
- hexylcaine
- hexylcaine
- hexylcaine
- hexylcaine
- hexylcaine
- hexylcaine
- hexylcaine
- hexylcaine
- hexylcaine hcl
- hexylcaine hcl
- hexylcaine hcl
- hexylcaine hydrochloride
- hexylcaine hydrochloride
- hexylcaine hydrochloride
- hexylcaine hydrochloride
- hexylcaine hydrochloride
- hexylcainum
- hexylcainum
- osmocaine
Organizations
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Merck | For profit | NDA2 | — |
| Sharp & Dohme | For profit | NDA | Jun 1, 1949 |