CDEK
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tegafur

Small moleculeexperimental

Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU. — Wikipedia

Clinical trial activity

536 trials · 265 clinical orgs · 0 marketing orgs

Phase 1
74
Phase 2
450
Phase 3
103
Phase 4
13

Earliest trial started Apr 1, 1996 (NCT00002801)

Timeline

1990s

  1. Jan 1, 1996

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 1996

    Earliest Phase 3 Sponsor(trial)

2000s

  1. Jan 1, 2000

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

O=c1[nH]c(=O)n(C2CCCO2)cc1F
Mol. weight
200.17 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Prodrug

Sources

Also known as

  • 1-(2-tetrahydrofuryl)-5-fluorouracil
  • 1-(2-tetrahydrofuryl)-5-fluorouracil
  • citofur
  • citofur
  • colloidal bismuth pectin
  • florafur
  • ft-207
  • ftorafur
  • futraful
  • mjf-12264
  • mjf-12264
  • s-1
  • s-1
  • tegafur
  • tegafur
  • tegafur
  • tegafur
  • tegafur
  • tegafur
  • tegafur
  • tegafur
  • tegafur
  • tegafur / gimeracil / oteracil
  • tegafur-uracil
  • teysuno
  • uftoral
  • uftoral
  • uftoral
  • ufur
  • uracil-futraful mixt.
  • youfuding

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07243938Phase 2Jan 15, 2026Huazhong University of Science and Technology
NCT07304258Phase 2Dec 12, 2025Hebei University
NCT07182565Phase 1/Phase 2 (Phase 2)Nov 18, 2025Sichuan University
NCT07263386Phase 2Oct 23, 2025Nanjing Medical University
NCT07007182Phase 2Oct 1, 2025Shandong University
NCT07018063Phase 2Oct 1, 2025Peking University
NCT07161453Phase 4Sep 30, 2025Dalian Medical University
NCT07151209Phase 2Sep 30, 2025Nanjing Medical University
NCT07072351Phase 1/Phase 2 (Phase 2)Sep 15, 2025Sichuan University
NCT07194005Phase 2Sep 4, 2025Fudan University
NCT07149181Phase 4Aug 31, 2025Dalian Medical University
NCT07132528Phase 4Aug 31, 2025Dalian Medical University
NCT07023315Phase 3Jul 31, 2025Akeso Pharmaceuticals, Inc.
NCT07033143Phase 2Jul 31, 2025Tianjin Medical University
NCT06973330Phase 2Jul 31, 2025Anhui Medical University
NCT07165847Phase 2Jul 23, 2025People's Liberation Army of China
NCT07068516Phase 3Jul 20, 2025Chinese Academy of Medical Sciences, Dalian Medical University, University of Electronic Science and Technology of China
NCT07070479Phase 2Jun 24, 2025Sun Yat-Sen University
NCT07026149Phase 2Jun 8, 2025Jiao Tong University
NCT07025889Phase 1/Phase 2 (Phase 2)Jun 2, 2025Jiao Tong University
Showing 20 of 536 trials
Page 1 / 27

Organizations

Research & Development (265)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Chinese Academy of Medical SciencesAcademic/Hospital554842009
OtsukaFor profit412731996
Fudan UniversityAcademic/Hospital363352009
People's Liberation Army of ChinaGovernment252132009
Sun Yat-Sen UniversityAcademic/Hospital212122008
Zhejiang UniversityAcademic/Hospital201942010
Jiao Tong UniversityAcademic/Hospital171422016
Nanjing Medical UniversityAcademic/Hospital161432016
Peking UniversityAcademic/Hospital161132005
Fujian Medical UniversityAcademic/Hospital151342016
Tianjin Medical UniversityAcademic/Hospital151232009
National Taiwan UniversityAcademic/Hospital13832003
University of UlsanAcademic/Hospital131022004
Chang Gung UniversityAcademic/Hospital12332008
Hebei UniversityAcademic/Hospital12932009
National Cancer Center, KoreaGovernment12732004
Yonsei UniversityAcademic/Hospital121032006
National Cheng Kung UniversityAcademic/Hospital11222003
Government of TaiwanGovernment9822003
Hallym UniversityAcademic/Hospital9722005
265 organizations
Page 1 / 14