fenofibrate

Trade name: fenoglide

Small moleculeapproved

Approved

Dec 31, 1993

Fenofibrate, sold under the brand name Tricor among others, is an oral medication of the fibrate class used to treat abnormal blood lipid levels. It is less commonly used compared to statins because it treats a different type of cholesterol abnormality to statins. While statins have strong evidence for reducing heart disease and death, there is evidence to suggest that fenofibrate also reduces the risk of heart disease and death. However, this seems only to apply to specific populations of people with elevated triglyceride levels and reduced high-density lipoprotein (HDL) cholesterol. Its use is recommended together with dietary changes. — Wikipedia

Clinical trial activity

220 trials · 193 clinical orgs · 49 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Sep 1, 1999 (NCT00000620)

Timeline

1990s

Dec 31, 1993
Earliest FDA Approval
Dec 31, 1993
AbbVie — NDA Secondary Org
Jan 1, 1999
Earliest Phase 3 Sponsor(trial)

2000s

Jan 1, 2002
Earliest Phase 1 Sponsor(trial)
Jan 1, 2002
Earliest Phase 2 Sponsor(trial)
Apr 9, 2002
Rhodes Pharmaceuticals, L.P. — Marketing Organization
Oct 27, 2003
Impax Laboratories — Marketing Organization
Nov 30, 2004
Lupin — NDA Secondary Org
May 7, 2005
SkyePharma AG — NDA Secondary Org
Oct 31, 2005
Sun Pharmaceuticals — Marketing Organization
Dec 29, 2005
Mylan — Marketing Organization
Jan 11, 2006
Cipher Pharmaceuticals Inc. — NDA Secondary Org
Aug 10, 2007
Santarus — NDA Secondary Org
Aug 10, 2007
Salix — NDA Secondary Org
Aug 14, 2009
University of Pennsylvania — NDA Secondary Org

2010s

Dec 23, 2011
Lupin — Marketing Organization
Mar 1, 2012
Dr. Reddy's Laboratories — Marketing Organization
Apr 5, 2012
Bausch Health Companies — Marketing Organization
Oct 23, 2012
Rising Pharmaceuticals — Marketing Organization
Jul 18, 2013
Anchen Pharmaceuticals, Inc — Marketing Organization
Jul 18, 2013
Par Pharmaceuticals — Marketing Organization
Jul 26, 2013
Apotex — Marketing Organization
Oct 7, 2015
Actavis — Marketing Organization
Oct 7, 2015
Allergan PLC (2015) — Marketing Organization
May 5, 2016
Aurobindo Pharma — Marketing Organization
Jul 12, 2016
Hetero Labs Ltd — Marketing Organization
Dec 15, 2016
Cipla — Marketing Organization
Mar 28, 2017
Invagen Pharms — Marketing Organization
Apr 7, 2017
Glenmark Pharmaceuticals — Marketing Organization
May 12, 2017
Alembic — Marketing Organization
Nov 16, 2017
Reyoung Pharma Co Ltd — Marketing Organization
Nov 16, 2017
Austarpharma — Marketing Organization
Feb 9, 2018
Amneal Pharmaceuticals — Marketing Organization
Apr 30, 2018
Amerigen Pharmaceuticals — Marketing Organization
Apr 30, 2018
Ani Pharmaceuticals — Marketing Organization
Jun 26, 2018
Torrent Pharmaceuticals Limited — Marketing Organization
Jul 20, 2018
Ajanta Pharma Ltd — Marketing Organization
Aug 17, 2018
Graviti Pharmaceuticals — Marketing Organization
Aug 17, 2018
Adaptis Pharma — Marketing Organization
Aug 28, 2018
Prinston Inc — Marketing Organization
Feb 11, 2019
Orit Labs Llc — Marketing Organization
Feb 11, 2019
Chartwell Pharmaceuticals — Marketing Organization
Apr 19, 2019
Ingenus Pharmaceuticals — Marketing Organization
Apr 19, 2019
Novast Labs — Marketing Organization
Jul 5, 2019
TWi Biotechnology, Inc. — Marketing Organization
Jul 5, 2019
ScinoPharm Taiwan — Marketing Organization
Sep 6, 2019
Nuvo Research Inc. — Marketing Organization
Sep 6, 2019
Appco Pharma — Marketing Organization

2020s

Jun 12, 2020
MannKind Corp — Marketing Organization
Jun 12, 2020
Mankind Pharma — Marketing Organization
Jun 16, 2020
Micro Labs Ltd India — Marketing Organization
Dec 23, 2020
Yichang Humanwell Pharmaceutical Co.,Ltd — Marketing Organization
Sep 7, 2023
CREEKWOOD PHARMS — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Peroxisome proliferator-activated receptor alphaAGONIST
PPARA agonist
- Peroxisome proliferator-activated receptor alpha (PPARA) ↗

Approval history

approvedDec 31, 1993

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)(Oc1ccc(C(=O)c2ccc(Cl)cc2)cc1)C(=O)O

Mol. weight: 318.76 g/mol
Lipinski Ro5: Pass
Rule of 3: No
Chirality: Achiral Molecule
Inorganic: No
Polymer: No
Delivery: Oral
Availability: Prescription Only

Oral

Yes

Parenteral

Topical

Sources

Also known as

2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid
2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester
2-(4-(4-chlorophenoxy)phenoxy)propanoic acid
2-(4-(4'-chlorophenoxy)phenoxy)propionic acid
abt335
abt335
abt335
abt 335
abt-335
abt-335
abt-335
abt-335
antara
antara
choline fenofibrate
choline fenofibrate
choline fenofibrate
choline fenofibrate
choline fenofibrate
choline fenofibrate
choline ion
choline ion
choline ion
clorofibrate
fenobrate
fenocor-67
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate
fenofibrate / pravastatin
fenofibrate / simvastatin
fenofibrato
fenofibrato
fenofibratum
fenofibratum
fenofibric acid
fenofibric acid
fenofibric acid
fenofibric acid
fenofibric acid
fenofibric acid
fenofibric acid
fenofibric acid potassium salt
fenofibric acid, (r)-isomer
fenofibric acid sodium salt
fenogal
fenogal
fenoglide
fenoglide
fibrate
fibricor
fibricor
finofibrate
finofibrate
fnf
fnf
hcg 004
isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
lipanthyl
lipanthyl
lipantil
lipantil
lipantil micro 200
lipantil micro 267
lipantil micro 67
lipidil
lipidil
lipidil
lipidil supra
lipidil supra
lipofen
lipofen
lipofene
lofibra
lofibra
procetofen
procetofen
procetofen
procetofene
procetofenic acid
supralip
supralip
supralip 160
tricor
tricor
tricor
triglide
triglide
trilipix
trilipix
trilipix
trilipix

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT07296458	Phase 3	Dec 17, 2025	People's Liberation Army of China
NCT07025005	Phase 4	Aug 30, 2025	Tanta University
NCT06905054	Phase 2	Apr 15, 2025	Mayo Clinic
NCT07104201	Early Phase 1 (Phase 1)	Mar 13, 2025	People's Liberation Army of China
NCT06191133	Phase 1	Nov 1, 2024	Case Western Reserve University
NCT06591455	Early Phase 1 (Phase 1)	Sep 15, 2024	People's Liberation Army of China
NCT06346743	Phase 2/Phase 3 (Phase 3)	Apr 30, 2024	Services Institute of Medical Sciences, Pakistan
NCT06293417	N/A	Mar 1, 2024	Korea University
NCT06755541	Phase 3	Jan 30, 2024	People's Liberation Army of China
NCT06755151	Phase 3	Jan 17, 2024	People's Liberation Army of China
NCT06155331	Phase 4	Dec 31, 2023	Tanta University
NCT06174402	Phase 2/Phase 3 (Phase 3)	Aug 21, 2023	People's Liberation Army of China
NCT06451900	Phase 4	Jul 1, 2023	Ain Shams University
NCT05365425	Phase 4	Jun 1, 2023	Daewon Pharmaceutical Co., Ltd., Seoul National University
NCT05781698	Phase 2	Mar 20, 2023	Menoufia University, Tanta University
NCT05753267	Phase 2/Phase 3 (Phase 3)	Feb 28, 2023	Menoufia University, Tanta University
NCT05751967	Phase 3	Feb 22, 2023	People's Liberation Army of China
NCT05749822	Phase 2/Phase 3 (Phase 3)	Feb 17, 2023	People's Liberation Army of China
NCT05813145	N/A	Jan 1, 2023	Damanhour University
NCT05909800	Phase 2	Sep 29, 2022	Children's Memorial Health Institute, Poland, Medical University of Warsaw

Showing 20 of 220 trials

Page 1 / 11

Organizations

Research & Development (193)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
Abbott	For profit	20	12	5	2001
Solvay	For profit	17	17	3	2002
People's Liberation Army of China	Government	12	12	3	2016
AstraZeneca	For profit	11	11	3	2005
Regeneron	For profit	8	0	4	2012
Sanofi	For profit	8	8	4	2012
Chong Kun Dang Pharmaceutical	For profit	6	6	2	2013
GlaxoSmithKline	For profit	6	3	3	2001
Merck	For profit	6	4	5	2002
Mutual Pharmaceutical	For profit	6	6	1	2007
National Institutes of Health (NIH)	Government	6	1	4	2002
National Heart, Lung, and Blood Institute (NHLBI)	Government	5	2	2	1999
University of Pennsylvania	Academic/Hospital	5	4	2	2005
Department of Veteran Affairs	Government	4	4	2	2005
Gachon University	Academic/Hospital	4	4	2	2005
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Government	4	1	4	1999
PRACS	For profit	4	0	1	2007
Ranbaxy	For profit	4	4	1	2002
Shriners Hospitals for Children	Academic/Hospital	4	0	3	2003
Tanta University	Academic/Hospital	4	4	3	2023

193 organizations

Page 1 / 10

Marketing (64)

Organization	Org type	Relationship	Date
AbbVie	For profit	NDA2	Dec 31, 1993
AbbVie	For profit	SYN	Sep 4, 2001
Abbott	For profit	NDA	—
Actavis	For profit	MKTG	Oct 7, 2015
Adaptis Pharma	For profit	MKTG	Aug 17, 2018
Ajanta Pharma Ltd	For profit	MKTG	Jul 20, 2018
Alembic	For profit	SYN	Feb 11, 2019
Alembic	For profit	MKTG	May 12, 2017
Alembic	For profit	SYN	May 12, 2017
Allergan PLC (2015)	For profit	MKTG	Oct 7, 2015
Amerigen Pharmaceuticals	For profit	MKTG	Apr 30, 2018
Amneal Pharmaceuticals	For profit	MKTG	Feb 9, 2018
Amneal Pharmaceuticals	For profit	SYN	Feb 9, 2018
Anchen Pharmaceuticals, Inc	For profit	MKTG	Jul 18, 2013
Ani Pharmaceuticals	For profit	MKTG	Apr 30, 2018
Ani Pharmaceuticals	For profit	SYN	Apr 30, 2018
Apotex	For profit	MKTG	Jul 26, 2013
Apotex	For profit	SYN	Jul 26, 2013
Appco Pharma	For profit	SYN	Sep 6, 2019
Appco Pharma	For profit	MKTG	Sep 6, 2019
Aurobindo Pharma	For profit	MKTG	May 5, 2016
Aurobindo Pharma	For profit	SYN	May 5, 2016
Austarpharma	For profit	MKTG	Nov 16, 2017
Bausch Health Companies	For profit	MKTG	Apr 5, 2012
CREEKWOOD PHARMS	For profit	MKTG	Sep 7, 2023
Chartwell Pharmaceuticals	For profit	MKTG	Feb 11, 2019
Cipher Pharmaceuticals Inc.	For profit	NDA2	Jan 11, 2006
Cipla	For profit	MKTG	Dec 15, 2016
Dr. Reddy's Laboratories	For profit	MKTG	Mar 1, 2012
Dr. Reddy's Laboratories	For profit	SYN	Sep 6, 2019
Glenmark Pharmaceuticals	For profit	MKTG	Apr 7, 2017
Graviti Pharmaceuticals	For profit	MKTG	Aug 17, 2018
Hetero Labs Ltd	For profit	MKTG	Jul 12, 2016
Impax Laboratories	For profit	MKTG	Oct 27, 2003
Impax Laboratories	For profit	SYN	Sep 7, 2016
Ingenus Pharmaceuticals	For profit	MKTG	Apr 19, 2019
Invagen Pharms	For profit	MKTG	Mar 28, 2017
Lupin	For profit	NDA2	Nov 30, 2004
Lupin	For profit	MKTG	Dec 23, 2011
Lupin	For profit	SYN	Nov 30, 2004
Mankind Pharma	For profit	MKTG	Jun 12, 2020
MannKind Corp	For profit	MKTG	Jun 12, 2020
Micro Labs Ltd India	For profit	MKTG	Jun 16, 2020
Mylan	For profit	SYN	Oct 23, 2012
Mylan	For profit	MKTG	Dec 29, 2005
Novast Labs	For profit	MKTG	Apr 19, 2019
Nuvo Research Inc.	For profit	MKTG	Sep 6, 2019
Orit Labs Llc	For profit	MKTG	Feb 11, 2019
Par Pharmaceuticals	For profit	MKTG	Jul 18, 2013
Prinston Inc	For profit	MKTG	Aug 28, 2018
Reyoung Pharma Co Ltd	For profit	MKTG	Nov 16, 2017
Rhodes Pharmaceuticals, L.P.	For profit	MKTG	Apr 9, 2002
Rising Pharmaceuticals	For profit	MKTG	Oct 23, 2012
Rising Pharmaceuticals	For profit	SYN	Oct 23, 2012
Salix	For profit	NDA2	Aug 10, 2007
Santarus	For profit	NDA2	Aug 10, 2007
ScinoPharm Taiwan	For profit	MKTG	Jul 5, 2019
SkyePharma AG	For profit	NDA2	May 7, 2005
Sun Pharmaceuticals	For profit	MKTG	Oct 31, 2005
Sun Pharmaceuticals	For profit	SYN	Sep 7, 2017
TWi Biotechnology, Inc.	For profit	MKTG	Jul 5, 2019
Torrent Pharmaceuticals Limited	For profit	MKTG	Jun 26, 2018
University of Pennsylvania	Academic/Hospital	NDA2	Aug 14, 2009
Yichang Humanwell Pharmaceutical Co.,Ltd	For profit	MKTG	Dec 23, 2020