← Mechanisms of action
TYMS
SINGLE PROTEINHomo sapiens
Preferred name: Thymidylate synthase ChEMBL ↗
Linked proteins
Drugs acting on this target (17)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| nolatrexed | Antagonist | experimental | Small molecule | Thymidylate synthase antagonist |
| 2-fluoropyrimidine | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| brivudine phosphoramidate | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| capecitabine (xeloda) | Inhibitor | approved | Small molecule | TYMS inhibitor |
| Doxifluridine (furtulon) | Inhibitor | experimental | Small molecule | Thymidylate synthase inhibitor |
| floxuridine (fudr) | Inhibitor | approved | Small molecule | TYMS inhibitor |
| fluorouracil (efudex) | Inhibitor | approved | Small molecule | TYMS inhibitor |
| leucovorin | Inhibitor | approved | Small molecule | TYMS inhibitor |
| nolatrexed | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| nuc-3373 | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| onx-0801 | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| osi-7904l | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| pemetrexed (alimta) | Inhibitor | approved | Small molecule | TYMS inhibitor |
| plevitrexed | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| Raltitrexed (Tomudex) | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| tbi 302 | Inhibitor | experimental | Small molecule | TYMS inhibitor |
| tegafur | Inhibitor | experimental | Small molecule | Thymidylate synthase inhibitor |