Doxifluridine
Trade name: furtulon
Small moleculeexperimental
Doxifluridine (5'-deoxy-5-fluorouridine) is a second generation nucleoside analog prodrug developed by Roche and used as a cytostatic agent in chemotherapy in several Asian countries including China and South Korea. Doxifluridine is not FDA-approved for use in the USA. It is currently being evaluated in several clinical trials as a stand-alone or combination therapy treatment. — Wikipedia
Clinical trial activity
3 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
1
Earliest trial started Oct 1, 2001 (NCT00296322)
Timeline
2000s
- Jan 1, 2001
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
- RNADISRUPTING AGENT
RNA disrupting agent
- DNADISRUPTING AGENT
DNA disrupting agent
- DNAINHIBITOR
DNA inhibitor
- Thymidylate synthaseINHIBITOR
Thymidylate synthase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)[C@H](O)[C@@H]1O- Mol. weight
- 246.19 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- WikipediaDoxifluridine ↗
- ChEMBLCHEMBL1130 ↗
Also known as
- 5'-deoxy-5-fluorouridine
- 5'-deoxy-5-fluorouridine
- 5'-deoxy-5-fluorouridine
- 5'-deoxy-5'-fluorouridine
- 5-dfur
- 5-dfur
- 5-dfur
- 5-dfur
- 5'-dfur
- 5'-fluoro-5'-deoxyuridine
- doxfluridine
- doxifluridine
- doxifluridine
- doxifluridine
- doxifluridine
- doxifluridine
- doxifluridine
- doxifluridine
- doxyfluridine
- flutron
- furtulon
- furtulon
- ro 21-9738
- uridine-5'-deoxy-5-fluoro-
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01401075 | Phase 4 | Mar 1, 2006 | Abnoba, University of Ulsan |
| NCT00296335 | Phase 3 | Feb 1, 2002 | Hallym University, University of Ulsan |
| NCT00296322 | Phase 3 | Oct 1, 2001 | Hallym University, University of Ulsan |
Showing 3 of 3 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Ulsan | Academic/Hospital | 3 | 2 | 2 | 2001 |
| Hallym University | Academic/Hospital | 2 | 0 | 1 | 2001 |
| Abnoba | For profit | 1 | 1 | 1 | 2006 |
3 organizations
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