← Mechanisms of action
Soluble guanylate cyclase
PROTEIN COMPLEX GROUPHomo sapiens
Linked proteins
Drugs acting on this target (17)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| ataciguat | Activator | experimental | Small molecule | activator - GUCY1A2 |
| cinaciguat | Activator | experimental | Small molecule | Soluble guanylate cyclase activator |
| isosorbide (isordil) | Activator | approved | Small molecule | Soluble guanylate cyclase activator |
| iw-1973 | Activator | experimental | Small molecule | activator - GUCY1A2 |
| nitric oxide (inomax) | Activator | approved | Small molecule | Soluble guanylate cyclase activator |
| nitroglycerin (transderm-nitro) | Activator | approved | Small molecule | Soluble guanylate cyclase activator |
| Olinciguat | Activator | experimental | Small molecule | Soluble guanylate cyclase activator |
| praliciguat | Activator | experimental | Small molecule | Soluble guanylate cyclase activator |
| runcaciguat | Activator | experimental | Small molecule | Soluble guanylate cyclase activator |
| tetranitropentaerythritol | Activator | experimental | Small molecule | Soluble guanylate cyclase activator |
| vericiguat (Verquvo) | Activator | approved | Small molecule | Soluble guanylate cyclase activator |
| iw-3300 | Agonist | experimental | Small molecule | Soluble guanylate cyclase agonist |
| iw-9179 | Agonist | experimental | Small molecule | Soluble guanylate cyclase agonist |
| vericiguat (Verquvo) | Agonist | approved | Small molecule | Soluble guanylate cyclase agonist |
| methylene blue (proveblue) | Inhibitor | approved | Small molecule | Soluble guanylate cyclase inhibitor |
| Olinciguat | Positive allosteric modulator | experimental | Small molecule | Soluble guanylate cyclase positive allosteric modulator |
| riociguat (adempas) | Positive allosteric modulator | approved | Small molecule | Soluble guanylate cyclase positive allosteric modulator |