tetranitropentaerythritol
Small moleculeexperimental
Pentaerythritol tetranitrate is an organic nitrate that has been used for the treatment of angina pectoris. Upon administration, the drug undergoes exstensive metabolism to NO which causes vasodilation and the relaxation of smooth muscle cells. The compound belongs to a familiy of explosive substances and may be used accordingly. — NCATS
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2002 (NCT01355822)
Timeline
2000s
- Jan 1, 2002
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Studied for
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
[O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O- Mol. weight
- 316.1366 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATS10L39TRG1Z ↗
- ChEMBLCHEMBL466659 ↗
Also known as
- cardiacap
- cardiacap
- mycardol
- mycardol
- nitropentaerythrite
- nitropentaerythritol
- pentaerithritol tetranitrate
- pentaerithritol tetranitrate
- pentaerithrityl tetranitrate
- pentaerithrityl tetranitrate
- pentaerithrityl tetranitrate
- pentaerithrityl tetranitrate
- pentaerithrityl tetranitrate
- pentaerythrithyltetrantrate
- pentaerythritol tetranitrate
- pentaerythritol tetranitrate
- pentaerythritol tetranitrate
- pentaerythritol tetranitrate
- pentaerythritol tetranitrate
- pentanitrine
- pentanitrol
- pentanitrol
- pentritol tempules
- pentritol tempules
- peritrate
- peritrate
- peritrate sa
- tetranitropentaerythrite
- tetranitropentaerythrite
- tetranitropentaerythrite
- tetranitropentaerythrite
- tetranitropentaerythrite
- tetranitropentaerythritol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01030367 | N/A | Jan 1, 2007 | Julius-Maximilians University |
| NCT01355822 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2002 | Friedrich Schiller University |
Showing 2 of 2 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Friedrich Schiller University | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Julius-Maximilians University | Academic/Hospital | 1 | 1 | 1 | 2007 |
2 organizations
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