← Mechanisms of action
Gamma-secretase
PROTEIN COMPLEXHomo sapiens
Linked proteins
Drugs acting on this target (14)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| al101 | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| al102 | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| avagacestat | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| begacestat | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| ly3056480 | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| mk-0752 | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| nirogacestat (Ogsiveo) | Inhibitor | approved | Small molecule | Gamma-secretase inhibitor |
| rg-4733 | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| semagacestat | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| varegacestat | Inhibitor | experimental | Small molecule | Gamma-secretase inhibitor |
| e2212 | Modulator | experimental | Small molecule | Gamma-secretase modulator |
| gsm-779690t | Modulator | experimental | Small molecule | Gamma-secretase modulator |
| pf-06648671 | Modulator | experimental | Small molecule | Gamma-secretase modulator |
| tarenflurbil | Modulator | experimental | Small molecule | Gamma-secretase modulator |