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avagacestat

Small moleculeexperimental

Clinical trial activity

13 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
11
Phase 2
2
Phase 3
0
Phase 4
0

Earliest trial started Jun 1, 2007 (NCT01454115)

Timeline

2000s

  1. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

NC(=O)[C@@H](CCC(F)(F)F)N(Cc1ccc(-c2ncon2)cc1F)S(=O)(=O)c1ccc(Cl)cc1
Mol. weight
520.89 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • avagacestat
  • avagacestat
  • avagacestat
  • avagacestat
  • avagacestat
  • bms708163
  • bms 708163
  • bms-708163
  • bms-708163
  • bms-708163
  • bms-708163
  • bms-708163-01
  • bms-708163-01

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01002079Phase 1Aug 1, 2010Bristol-Myers Squibb, Pharmaceutical Research Associates, Inc. (PRA)
NCT01079819Phase 1Apr 1, 2010Bristol-Myers Squibb
NCT01057030Phase 1Mar 1, 2010Bristol-Myers Squibb
NCT01042314Phase 1Jan 1, 2010Bristol-Myers Squibb
NCT01039194Phase 1Jan 1, 2010Bristol-Myers Squibb
NCT00979316Phase 1Sep 1, 2009Bristol-Myers Squibb
NCT00890890Phase 2May 1, 2009Bristol-Myers Squibb
NCT00901498Phase 1May 1, 2009Bristol-Myers Squibb
NCT00860275Phase 1Apr 1, 2009Bristol-Myers Squibb
NCT00810147Phase 2Feb 1, 2009Bristol-Myers Squibb
NCT00828646Phase 1Oct 1, 2008Bristol-Myers Squibb
NCT00726726Phase 1Aug 1, 2008Bristol-Myers Squibb
NCT01454115Phase 1Jun 1, 2007Bristol-Myers Squibb
Showing 13 of 13 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Bristol-Myers SquibbFor profit131322007
Pharmaceutical Research Associates, Inc. (PRA)For profit1012010
2 organizations
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