tarenflurbil
Small moleculeexperimental
Tarenflurbil, Flurizan or R-flurbiprofen, is a single enantiomer of the racemate NSAID flurbiprofen. For several years, research and trials for the drug were conducted by Myriad Genetics, to investigate its potential as a treatment for Alzheimer's disease; that investigation concluded in June 2008 when the company announced it would discontinue development of the compound. — Wikipedia
Clinical trial activity
7 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
7
Phase 3
3
Phase 4
0
Earliest trial started Feb 1, 2002 (NCT00045123)
Timeline
Indications
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H](C(=O)O)c1ccc(-c2ccccc2)c(F)c1- Mol. weight
- 244.26 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTarenflurbil ↗
- ChEMBLCHEMBL190083 ↗
Also known as
- e-7869
- e-7869
- flurizan
- flurizan
- flurizan
- mpc7869
- mpc-7869
- mpc-7869
- mpc-7869
- mpc-7869
- (r)-2-fluoro-α-methyl(1,1'-biphenyl)-4-acetic acid
- (r)-2-fluoro-α-methyl(1,1'-biphenyl)-4-acetic acid
- (r)-flurbiprofen
- (r)-flurbiprofen
- tarenflurbil
- tarenflurbil
- tarenflurbil
- tarenflurbil
- tarenflurbil
- tmp001
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03715023 | Phase 2 | Nov 5, 2018 | Pulmocide Ltd |
| NCT03382431 | Phase 1/Phase 2 (Phase 2) | Nov 14, 2017 | hVIVO Services Limited, Pulmocide Ltd |
| NCT02686788 | Phase 2 | Aug 1, 2015 | Fraunhofer, J. W. Goethe University, SocraMetrics GmbH |
| NCT00380276 | Phase 3 | Sep 1, 2006 | Myrexis Inc. |
| NCT00322036 | Phase 3 | May 1, 2006 | Myrexis Inc. |
| NCT00105547 | Phase 3 | Feb 1, 2005 | Myrexis Inc. |
| NCT00045123 | Phase 2 | Feb 1, 2002 | Myrexis Inc. |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Myrexis Inc. | For profit | 4 | 4 | 2 | 2002 |
| Pulmocide Ltd | For profit | 2 | 2 | 1 | 2017 |
| Fraunhofer | For profit | 1 | 0 | 1 | 2015 |
| hVIVO Services Limited | For profit | 1 | 0 | 1 | 2017 |
| J. W. Goethe University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| SocraMetrics GmbH | For profit | 1 | 0 | 1 | 2015 |
6 organizations
Page 1 / 1