← Mechanisms of action
TNF
SINGLE PROTEINHomo sapiens
Preferred name: TNF-alpha ChEMBL ↗
Linked proteins
Drugs acting on this target (60)
| Active Pharmaceutical Ingredient | Mechanism Type ▲ | Approval Status | API Type | Mechanism of Action |
|---|---|---|---|---|
| colloidal gold-bound tumor necrosis factor | Agonist | experimental | Recombinant protein | TNF agonist |
| abbv-154 | Antagonist | experimental | mAb | TNFA |
| AMG-966 | Antagonist | experimental | mAb | TNFA |
| B-C7 | Antagonist | experimental | mAb | TNFA |
| ia-14069 | Antagonist | experimental | Small molecule | TNFA |
| JNJ-63823539 | Antagonist | experimental | mAb | TNFA |
| sar441566 | Antagonist | experimental | Small molecule | TNFA |
| sb24m | Antagonist | experimental | mAb | TNFA |
| UCB-0159 | Antagonist | experimental | mAb | TNFA |
| xtmab-16 | Antagonist | experimental | mAb | TNFA |
| isis 104838 | Antisense inhibitor | experimental | Nucleic acid | TNF antisense inhibitor |
| abbv-3373 | Binding agent | experimental | mAb | TNF-alpha binding agent |
| jnj-61178104 | Binding agent | experimental | mAb | TNFA |
| tnf-kinoid | Immunity, active | experimental | Vaccine | TNF immunity, active |
| abbv-257 | Immunity, passive | experimental | mAb | TNF immunity, passive |
| abt-122 | Immunity, passive | experimental | mAb | TNF immunity, passive |
| abbv-3373 | Inhibitor | experimental | mAb | TNF inhibitor |
| adalimumab (humira) | Inhibitor | approved | mAb | TNF inhibitor |
| avx 470 | Inhibitor | experimental | mAb | TNF inhibitor |
| az-9773 (CytoFab) | Inhibitor | experimental | Animal product | TNF inhibitor |
| bcd-121 | Inhibitor | experimental | mAb | TNF inhibitor |
| certolizumab pegol (cimzia) | Inhibitor | approved | mAb | TNF inhibitor |
| dlx105 | Inhibitor | experimental | mAb | TNF inhibitor |
| esba105 | Inhibitor | experimental | mAb | TNF inhibitor |
| etanercept (enbrel) | Inhibitor | approved | Recombinant protein | TNF inhibitor |
| golimumab (simponi) | Inhibitor | approved | mAb | TNF inhibitor |
| gsk2800528 | Inhibitor | experimental | mAb | TNF inhibitor |
| hemay007 | Inhibitor | experimental | Small molecule | TNF inhibitor |
| humanized tnf-alpha monoclonal antibody | Inhibitor | experimental | mAb | TNF inhibitor |
| imb-101 | Inhibitor | experimental | mAb | TNF inhibitor |
| infliximab (remicade) | Inhibitor | approved | mAb | TNF inhibitor |
| isomyosamine | Inhibitor | experimental | Small molecule | TNF inhibitor |
| jnj-61178104 | Inhibitor | experimental | mAb | TNF inhibitor |
| lenercept | Inhibitor | experimental | Recombinant protein | TNF inhibitor |
| licaminlimab | Inhibitor | experimental | mAb | TNF inhibitor |
| ly3016859 | Inhibitor | experimental | mAb | TNF inhibitor |
| ly3114062 | Inhibitor | experimental | mAb | TNF inhibitor |
| mak 195f | Inhibitor | experimental | mAb | TNF inhibitor |
| medi7352 | Inhibitor | experimental | mAb | TNF inhibitor |
| nav-240 | Inhibitor | experimental | mAb | TNF inhibitor |
| nerelimomab | Inhibitor | experimental | mAb | TNF inhibitor |
| np000888 | Inhibitor | experimental | Small molecule | TNF inhibitor |
| oprx-106 | Inhibitor | experimental | Recombinant protein | TNF inhibitor |
| ozoralizumab | Inhibitor | experimental | mAb | TNF inhibitor |
| pegsunercept | Inhibitor | experimental | Recombinant protein | TNF inhibitor |
| peys606 | Inhibitor | experimental | Gene therapy | TNF inhibitor |
| pf-05230905 | Inhibitor | experimental | mAb | TNF inhibitor |
| placulumab | Inhibitor | experimental | mAb | TNF inhibitor |
| ren-1654 | Inhibitor | experimental | Small molecule | TNF inhibitor |
| sar442970 | Inhibitor | experimental | mAb | TNF inhibitor |
| sor102 | Inhibitor | experimental | Small molecule | TNF inhibitor |
| ssr150106 | Inhibitor | experimental | Small molecule | TNF inhibitor |
| tanfanercept | Inhibitor | experimental | Recombinant protein | TNF inhibitor |
| tumor necrosis factor receptor type i, p55 soluble fragment | Inhibitor | experimental | Recombinant protein | TNF inhibitor |
| v565 | Inhibitor | experimental | mAb | TNF inhibitor |
| xpro1595 | Inhibitor | experimental | mAb | TNF inhibitor |
| yhb1411-2 | Inhibitor | experimental | mAb | TNF inhibitor |
| tasonermine | Supplementation | experimental | Small molecule | TNF supplementation |
| tgaac94 | Supplementation | experimental | Gene therapy | TNF supplementation |
| tumor necrosis factor | Supplementation | experimental | Recombinant protein | TNF supplementation |