tumor necrosis factor
Recombinant proteinexperimental
Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. TNF is produced primarily by activated macrophages, and induces inflammation by binding to its receptors on other cells. It is a member of the tumor necrosis factor superfamily, a family of transmembrane proteins that are cytokines, chemical messengers of the immune system. Excessive production of TNF plays a critical role in several inflammatory diseases, and TNF-blocking drugs are often employed to treat these diseases. — Wikipedia
Clinical trial activity
15 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
8
Phase 3
3
Phase 4
0
Earliest trial started Feb 1, 1992 (NCT00001296)
Timeline
Indications
Studied for
- Ascites · Phase 2
- Chemoradiotherapy · Phase 2/Phase 3
- Colorectal Neoplasms · Phase 2
- Digestive System Neoplasms · Phase 2
- HIV Infections · Phase 2
- Lymphoma · Phase 1
- Melanoma · Phase 3
- Nasopharyngeal Carcinoma · Phase 2/Phase 3
- Neoplasms · Phase 1
- Peritoneal Neoplasms · Phase 2
- Receptors, Tumor Necrosis Factor, Type I · Phase 2/Phase 3
- Sarcoma · Phase 2
- Sarcoma, Kaposi · Phase 1
- Spondylitis, Ankylosing · Phase 2
Mechanism of action
- TNF-alphaSupplementation
TNF supplementation
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTumor necrosis factor ↗
- WikipediaTumor necrosis factor alpha ↗
Also known as
- tnf alpha
- tnf-alpha
- tumor necrosis factor
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07196540 | Phase 2 | Sep 26, 2025 | Sun Yat-Sen University |
| NCT06433869 | Phase 2 | Dec 14, 2023 | Sun Yat-Sen University |
| NCT05755685 | Phase 2 | Feb 10, 2023 | Zhejiang University |
| NCT05433597 | Phase 2/Phase 3 (Phase 3) | Jul 1, 2022 | Sun Yat-Sen University |
| NCT01490047 | Phase 1 | Jan 1, 2013 | Johns Hopkins University, J. W. Goethe University, Ludwig Institute for Cancer Research |
| NCT01347801 | N/A | Mar 1, 2011 | Novo Nordisk, University of Copenhagen |
| NCT01452958 | N/A | Jun 1, 2010 | Aarhus University, Lundbeck |
| NCT02456363 | Phase 2 | Nov 1, 2009 | Chung Shan Medical University |
| NCT00630006 | N/A | Jan 1, 2007 | Kaohsiung Medical University |
| NCT01953393 | N/A | Apr 30, 2006 | University of Copenhagen |
| NCT00002262 | Phase 1 | Nov 2, 1999 | University of California, San Francisco |
| NCT00001004 | Phase 2 | Nov 2, 1999 | National Institute of Allergy and Infectious Diseases (NIAID) |
| NCT00019968 | Phase 2 | Aug 1, 1999 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
| NCT00003789 | Phase 3 | Mar 1, 1999 | American College of Surgeons, National Cancer Institute (NCI) |
| NCT00001296 | Phase 3 | Feb 1, 1992 | National Cancer Institute (NCI) |
Showing 15 of 15 trials
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Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 3 | 2 | 2 | 1992 |
| Sun Yat-Sen University | Academic/Hospital | 3 | 3 | 2 | 2022 |
| University of Copenhagen | Academic/Hospital | 2 | 2 | 1 | 2006 |
| Aarhus University | Academic/Hospital | 1 | 1 | 1 | 2010 |
| American College of Surgeons | Academic/Hospital | 1 | 0 | 1 | 1999 |
| Chung Shan Medical University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Johns Hopkins University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| J. W. Goethe University | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Kaohsiung Medical University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Ludwig Institute for Cancer Research | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Lundbeck | For profit | 1 | 0 | 1 | 2010 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 1 | 1 | 1 | 1999 |
| National Institutes of Health (NIH) | Government | 1 | 1 | 1 | 1999 |
| Novo Nordisk | For profit | 1 | 0 | 1 | 2011 |
| University of California, San Francisco | Academic/Hospital | 1 | 1 | 1 | 1999 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2023 |
16 organizations
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